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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.11.000
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.556
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.523
1rp7TZDPyruvate dehydrogenase E1 component1.2.4.10.522
3lq4TDPPyruvate dehydrogenase E1 component1.2.4.10.516
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.499
2qtcTDKPyruvate dehydrogenase E1 component1.2.4.10.465
1l8aTDPPyruvate dehydrogenase E1 component1.2.4.10.449
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.446
3rimTPPTransketolase2.2.1.10.446
3uptTPPTransketolase/0.445
1tkbN1TTransketolase 12.2.1.10.444
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.442