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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.11.000
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.622
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.541
5cnoANPEpidermal growth factor receptor2.7.10.10.533
5cnnANPEpidermal growth factor receptor2.7.10.10.526
3w32W32Epidermal growth factor receptor2.7.10.10.491
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.490
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.476
1hckATPCyclin-dependent kinase 22.7.11.220.473
2qoqANPEphrin type-A receptor 32.7.10.10.473
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.465
1b38ATPCyclin-dependent kinase 22.7.11.220.461
2gs7ANPEpidermal growth factor receptor2.7.10.10.456
3bu5ATPInsulin receptor2.7.10.10.455
2qo7ANPEphrin type-A receptor 32.7.10.10.454
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.454
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.453
4j95ACPFibroblast growth factor receptor 2/0.444
4y93746Tyrosine-protein kinase/0.444
4j99ACPFibroblast growth factor receptor 2/0.443
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.441
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.441