sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3lm4 | HPX | Catechol 2,3-dioxygenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3lm4 | HPX | Catechol 2,3-dioxygenase | / | 1.000 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.538 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.501 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.493 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.492 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.490 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.489 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.488 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.486 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.485 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.484 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.482 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.481 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.479 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.478 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.476 | |
| 1jlc | FTC | Gag-Pol polyprotein | 2.7.7.49 | 0.475 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.475 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.475 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.475 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.475 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.474 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.473 | |
| 3pn1 | IVH | DNA ligase | / | 0.472 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.472 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.471 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.471 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.470 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.470 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.470 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.470 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.469 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.469 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.468 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.467 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.467 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4iae | 1DX | Alr2278 protein | / | 0.466 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.465 | |
| 2oh4 | GIG | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.465 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.465 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.465 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.465 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.465 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.464 | |
| 2zym | ACX | Periplasmic binding protein | / | 0.464 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.464 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.463 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.463 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.463 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 3ix4 | TX1 | Transcriptional activator protein LasR | / | 0.462 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.462 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.461 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.461 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.461 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.460 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.460 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.459 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.459 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.459 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.458 | |
| 3fnf | JPM | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.458 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.457 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.457 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.457 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.457 | |
| 4o7u | THF | Thymidylate synthase | / | 0.457 | |
| 4yau | FAD | NADPH--cytochrome P450 reductase | / | 0.457 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.456 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.456 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.456 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.456 | |
| 3rl3 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.456 | |
| 4b1f | KRH | Glutamate racemase | / | 0.456 | |
| 4iah | 1DX | Alr2278 protein | / | 0.456 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.456 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.456 | |
| 2yhu | WHF | Pteridine reductase | / | 0.455 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.455 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.454 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.454 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.454 | |
| 3up3 | XCA | aceDAF-12 | / | 0.454 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4jsg | Q10 | Nitric oxide synthase, brain | 1.14.13.39 | 0.454 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.453 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.453 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.451 | |
| 2yxj | N3C | Bcl-2-like protein 1 | / | 0.451 | |
| 3bac | 3B9 | DNA ligase | / | 0.451 | |
| 4bvh | OCZ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.451 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.451 | |
| 4uga | Q05 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.451 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.451 | |
| 1el4 | CTZ | Obelin | / | 0.450 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.450 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.450 | |
| 3fnh | JPJ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.450 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.449 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.449 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.449 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.449 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.449 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.449 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.449 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.449 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.448 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.448 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.448 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.448 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.447 | |
| 5dp2 | NAP | CurF | / | 0.447 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.446 | |
| 1ysi | N3B | Bcl-2-like protein 1 | / | 0.446 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.446 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.446 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.446 | |
| 2j5s | KTA | Alr4455 protein | / | 0.446 | |
| 2wks | CB6 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.446 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.446 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.446 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.446 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.446 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.446 | |
| 1kia | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.445 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.445 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.445 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 3n5w | XFJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.445 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.445 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.445 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.444 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.444 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.444 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4n1f | CZH | Obelin | / | 0.444 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.443 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2jfa | RAL | Estrogen receptor | / | 0.443 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.443 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.443 | |
| 3dqr | JI2 | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 3gki | CLR | Niemann-Pick C1 protein | / | 0.443 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.443 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.442 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.442 | |
| 2hx4 | 4HX | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.442 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.442 | |
| 3qkd | HI0 | Bcl-2-like protein 1 | / | 0.442 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.442 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.442 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1fml | RTL | Retinol dehydratase | / | 0.441 | |
| 1gal | FAD | Glucose oxidase | 1.1.3.4 | 0.441 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 3dge | ADP | Sensor histidine kinase | / | 0.441 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.441 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.441 | |
| 3qv1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.441 | |
| 3sso | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.441 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.441 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4iji | 99T | Glutathione S-transferase-like protein YibF | / | 0.441 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.440 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.440 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.440 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.440 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.440 | |
| 2b35 | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.440 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3p9t | TCL | Repressor | / | 0.440 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.440 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.440 | |
| 4lux | QJ8 | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.440 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.440 |