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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lltANPProtein serine/threonine kinase-1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lltANPProtein serine/threonine kinase-1/1.000
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.555
2yaaATPDeath-associated protein kinase 2/0.549
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.516
4qnyANPMitogen activated protein kinase, putative/0.500
5cvfATPCasein kinase II subunit alpha2.7.11.10.494
3gu7ADPDeath-associated protein kinase 12.7.11.10.490
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.485
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.480
5av2KMPDeath-associated protein kinase 12.7.11.10.479
4fv6E57Mitogen-activated protein kinase 12.7.11.240.478
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.475
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.475
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.474
3c4xATPRhodopsin kinase/0.473
3dfcANPDeath-associated protein kinase 12.7.11.10.473
4ic7ANPMitogen-activated protein kinase 72.7.11.240.473
5av3KMPDeath-associated protein kinase 12.7.11.10.471
1jklANPDeath-associated protein kinase 12.7.11.10.470
4ysjADPCalmodulin-like domain protein kinase/0.469
3i60E86Mitogen-activated protein kinase 12.7.11.240.466
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.466
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4anmWULCasein kinase II subunit alpha2.7.11.10.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.464
4btjATPTau-tubulin kinase 12.7.11.10.463
2ijmADPFocal adhesion kinase 12.7.10.20.461
3begANPSRSF protein kinase 12.7.11.10.460
5dosATPAurora kinase A2.7.11.10.459
1jkkANPDeath-associated protein kinase 12.7.11.10.456
3c4wATPRhodopsin kinase/0.454
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.453
4l9i8PRRhodopsin kinase/0.453
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.452
4j95ACPFibroblast growth factor receptor 2/0.452
1ig1ANPDeath-associated protein kinase 12.7.11.10.451
4jboWPHAurora kinase A2.7.11.10.451
3bu5ATPInsulin receptor2.7.10.10.450
4aguD15Cyclin-dependent kinase-like 1/0.450
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4h3qANPMitogen-activated protein kinase 12.7.11.240.449
3orpAGSSerine/threonine protein kinase/0.448
2w4jADPDeath-associated protein kinase 12.7.11.10.447
4nifANPMitogen-activated protein kinase 12.7.11.240.447
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.446
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.445
5dnrATPAurora kinase A2.7.11.10.445
1dawANPCasein kinase II subunit alpha2.7.11.10.444
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
4jbpYPHAurora kinase A2.7.11.10.443
3juhANPCasein kinase II subunit alpha2.7.11.10.441
1m2pHNACasein kinase II subunit alpha2.7.11.10.440
4ez50RSCyclin-dependent kinase 62.7.11.220.440