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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lkiATPFructokinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lkiATPFructokinase/1.000
3gbuATPUncharacterized sugar kinase PH14592.7.10.571
5c3zACPRibokinase/0.515
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.506
5c3yAN2Ribokinase/0.485
3nbvANPKetohexokinase/0.484
3umoATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.478
2hw1ANPKetohexokinase/0.469
1rfvADPPyridoxal kinase2.7.1.350.458
5c41ACPRibokinase/0.458
1ppjANYCytochrome b/0.453
3q92XNBKetohexokinase/0.453
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.452
3nc9TR3Ketohexokinase/0.448
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.447
3qaiXNNKetohexokinase/0.445
1gqtACPRibokinase/0.443