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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lfcZ86Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lfcZ86Mitogen-activated protein kinase 14/1.000
3gcq1BUMitogen-activated protein kinase 14/0.509
3iw8HIZMitogen-activated protein kinase 14/0.502
3hv3R49Mitogen-activated protein kinase 14/0.458
2bakAQZMitogen-activated protein kinase 14/0.451
4a9yAQZMitogen-activated protein kinase 14/0.451
3p99LNPLanosterol 14-alpha-demethylase/0.443
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442