Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
3lbo | LDT | Aldose reductase | 1.1.1.21 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
3lbo | LDT | Aldose reductase | 1.1.1.21 | 1.000 | |
3lql | LDT | Aldose reductase | 1.1.1.21 | 0.888 | |
3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.849 | |
1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.726 | |
2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.714 | |
3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.711 | |
2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.697 | |
1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.692 | |
2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.686 | |
2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.680 | |
4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.679 | |
2dux | ZST | Aldose reductase | 1.1.1.21 | 0.671 | |
3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.645 | |
2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.644 | |
4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.644 | |
1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.642 | |
2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.642 | |
1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.641 | |
1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.641 | |
2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.641 | |
3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.640 | |
2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.638 | |
2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.637 | |
2iki | 388 | Aldose reductase | 1.1.1.21 | 0.627 | |
3len | ZST | Aldose reductase | 1.1.1.21 | 0.622 | |
2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.618 | |
2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.613 | |
2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.609 | |
3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.609 | |
3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.607 | |
2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.606 | |
2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.604 | |
2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.602 | |
2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.601 | |
2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.601 | |
1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.597 | |
3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.597 | |
2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.596 | |
2duz | ZST | Aldose reductase | 1.1.1.21 | 0.593 | |
2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.593 | |
2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.593 | |
3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.587 | |
3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.581 | |
2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.578 | |
3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.577 | |
2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.576 | |
2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.576 | |
2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.575 | |
3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.568 | |
1iei | ZES | Aldose reductase | 1.1.1.21 | 0.561 | |
2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.554 | |
2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.550 | |
2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.544 | |
1frb | ZST | Aldose reductase-related protein 2 | / | 0.543 | |
1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.521 | |
3ght | LDT | Aldose reductase | 1.1.1.21 | 0.516 | |
3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.513 | |
1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.510 | |
1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.506 | |
5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.501 | |
2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.500 | |
2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.496 | |
2agt | FID | Aldose reductase | 1.1.1.21 | 0.495 | |
2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.490 | |
1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.485 | |
3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.479 | |
1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.478 | |
1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.475 | |
4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.474 | |
4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.473 | |
1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.470 | |
4phl | PIL | Phosphodiesterase | / | 0.469 | |
2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.468 | |
3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.467 | |
3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.465 | |
3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.461 | |
1eko | I84 | Aldose reductase | 1.1.1.21 | 0.460 | |
1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.457 | |
2inz | OHP | Aldose reductase | 1.1.1.21 | 0.456 | |
3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.456 | |
3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.456 | |
4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
2pdw | FID | Aldose reductase | 1.1.1.21 | 0.454 | |
3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.454 | |
4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
5kp2 | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 | / | 0.454 | |
2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
2oaz | I96 | Methionine aminopeptidase 2 | / | 0.453 | |
3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.453 | |
2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.452 | |
4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.452 | |
2v0m | KLN | Cytochrome P450 3A4 | / | 0.451 | |
1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.450 | |
3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.450 | |
3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.449 | |
3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
4ea2 | RWZ | Dehydrosqualene synthase | / | 0.449 | |
1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.448 | |
4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.447 | |
2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
1lnm | DTX | Bilin-binding protein | / | 0.446 | |
3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.446 | |
4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.446 | |
4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.446 | |
4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.446 | |
1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.445 | |
1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.445 | |
1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.445 | |
2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.445 | |
2pdy | FID | Aldose reductase | 1.1.1.21 | 0.445 | |
2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.444 | |
3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.444 | |
4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.443 | |
4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
5d5a | CAU | Beta-2 adrenergic receptor | / | 0.443 | |
1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.441 | |
2cbq | TH2 | Neocarzinostatin | / | 0.441 | |
3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.441 | |
1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.440 | |
3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 |