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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lboLDTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3lboLDTAldose reductase1.1.1.211.000
3lqlLDTAldose reductase1.1.1.210.888
3m4h388Aldose reductase1.1.1.210.849
1z3n3NAAldose reductase1.1.1.210.726
2fz9ZSTAldose reductase1.1.1.210.714
3m64393Aldose reductase1.1.1.210.711
2pdxZSTAldose reductase1.1.1.210.697
1z8962PAldose reductase1.1.1.210.692
2ikj393Aldose reductase1.1.1.210.686
2dv0ZSTAldose reductase1.1.1.210.680
4yu153NAldose reductase1.1.1.210.679
2duxZSTAldose reductase1.1.1.210.671
3lz5LDTAldose reductase1.1.1.210.645
2pdmZSTAldose reductase1.1.1.210.644
4gca2X9Aldose reductase1.1.1.210.644
1t41ID5Aldose reductase1.1.1.210.642
2ikhLITAldose reductase1.1.1.210.642
1t40ID5Aldose reductase1.1.1.210.641
1us0LDTAldose reductase1.1.1.210.641
2hv5ZSTAldose reductase1.1.1.210.641
3mb9ZSTAldose reductase1.1.1.210.640
2i16LDTAldose reductase1.1.1.210.638
2hvnZSTAldose reductase1.1.1.210.637
2iki388Aldose reductase1.1.1.210.627
3lenZSTAldose reductase1.1.1.210.622
2qxwLDTAldose reductase1.1.1.210.618
2pdu393Aldose reductase1.1.1.210.613
2pd5ZSTAldose reductase1.1.1.210.609
3ld5LDTAldose reductase1.1.1.210.609
3m0iZSTAldose reductase1.1.1.210.607
2pzn393Aldose reductase1.1.1.210.606
2pdbZSTAldose reductase1.1.1.210.604
2fz8ZSTAldose reductase1.1.1.210.602
2i17LDTAldose reductase1.1.1.210.601
2pdg47DAldose reductase1.1.1.210.601
1pwlBFIAldose reductase1.1.1.210.597
3mc5393Aldose reductase1.1.1.210.597
2pdc393Aldose reductase1.1.1.210.596
2duzZSTAldose reductase1.1.1.210.593
2pdfZSTAldose reductase1.1.1.210.593
2pdh47DAldose reductase1.1.1.210.593
3t423T4Aldose reductase1.1.1.210.587
3ghuLDTAldose reductase1.1.1.210.581
2pdp393Aldose reductase1.1.1.210.578
3g5eQ74Aldose reductase1.1.1.210.577
2pdn47DAldose reductase1.1.1.210.576
2pdq47DAldose reductase1.1.1.210.576
2hvoZSTAldose reductase1.1.1.210.575
3ghrLDTAldose reductase1.1.1.210.568
1ieiZESAldose reductase1.1.1.210.561
2pdiZSTAldose reductase1.1.1.210.554
2fzdTOLAldose reductase1.1.1.210.550
2pdj393Aldose reductase1.1.1.210.544
1frbZSTAldose reductase-related protein 2/0.543
1zuaTOLAldo-keto reductase family 1 member B101.1.10.521
3ghtLDTAldose reductase1.1.1.210.516
3ghsLDTAldose reductase1.1.1.210.513
1el3I84Aldose reductase1.1.1.210.510
1ah3TOLAldose reductase1.1.1.210.506
5liu388Aldo-keto reductase family 1 member B101.1.10.501
2pdlTOLAldose reductase1.1.1.210.500
2pdkSBIAldose reductase1.1.1.210.496
2agtFIDAldose reductase1.1.1.210.495
2fzbTOLAldose reductase1.1.1.210.490
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.485
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.479
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.478
2f2kTGGAldose reductase1.1.1.210.478
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
2pd9FIDAldose reductase1.1.1.210.475
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.474
4wevSUZAldo-keto reductase family 1 member B101.1.10.473
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.470
4phlPILPhosphodiesterase/0.469
2aot2PMHistamine N-methyltransferase2.1.1.80.468
3b82NADExotoxin A2.4.2.360.467
3s3gTLTAldose reductase1.1.1.210.465
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
1h22E10Acetylcholinesterase3.1.1.70.461
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.461
3uonQNBMuscarinic acetylcholine receptor M2/0.461
1ekoI84Aldose reductase1.1.1.210.460
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.458
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.458
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.458
1obnASVIsopenicillin N synthase1.21.3.10.457
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.457
4u140HKMuscarinic acetylcholine receptor M3/0.457
2inzOHPAldose reductase1.1.1.210.456
3f3y4OABile salt sulfotransferase2.8.2.140.456
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.456
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.456
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
2pdwFIDAldose reductase1.1.1.210.454
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.454
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
5kp2COA3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2/0.454
2f3815MAldo-keto reductase family 1 member C3/0.453
2oazI96Methionine aminopeptidase 2/0.453
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
4fam0SZAldo-keto reductase family 1 member C3/0.453
4daj0HKMuscarinic acetylcholine receptor M3/0.453
2iqdLPAAldose reductase1.1.1.210.452
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.452
2v0mKLNCytochrome P450 3A4/0.451
1ry8RUTAldo-keto reductase family 1 member C3/0.450
3u2cSUZAldose reductase1.1.1.210.450
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.450
3zkyWT4Isopenicillin N synthase1.21.3.10.450
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
1ry0PG2Aldo-keto reductase family 1 member C3/0.449
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2ga2A19Methionine aminopeptidase 2/0.449
3zkuHCVIsopenicillin N synthase1.21.3.10.449
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.449
4ea2RWZDehydrosqualene synthase/0.449
1yw7A41Methionine aminopeptidase 2/0.448
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.447
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1lnmDTXBilin-binding protein/0.446
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3p2vDOYAldose reductase1.1.1.210.446
4bfxZVXPantothenate kinase2.7.1.330.446
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.446
4u163C0Muscarinic acetylcholine receptor M3/0.446
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.445
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.445
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.445
2aovC2MHistamine N-methyltransferase2.1.1.80.445
2pdyFIDAldose reductase1.1.1.210.445
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2qimZEAClass 10 plant pathogenesis-related protein/0.444
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.444
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.444
4hmn16JAldo-keto reductase family 1 member C3/0.444
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.443
4gn6TYLLactoperoxidase1.11.1.70.443
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
5d5aCAUBeta-2 adrenergic receptor/0.443
1p0pBCHCholinesterase3.1.1.80.441
2cbqTH2Neocarzinostatin/0.441
3v35NTIAldose reductase1.1.1.210.441
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2cekN8TAcetylcholinesterase3.1.1.70.440
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.440
3uweVJJAldo-keto reductase family 1 member C3/0.440
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.440
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.440