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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lbnGNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lbnGNPGTPase HRas/1.000
3v4fGNPGTPase HRas/0.738
3rs0GNPGTPase HRas/0.685
4dltGNPGTPase HRas/0.658
3k8yGNPGTPase HRas/0.657
2rgcGNPGTPase HRas/0.641
3rs7GNPGTPase HRas/0.633
3rs5GNPGTPase HRas/0.627
3i3sGNPGTPase HRas/0.621
3oivGNPGTPase HRas/0.619
4dlwGNPGTPase HRas/0.613
2rgeGNPGTPase HRas/0.599
4lhwGNPRas-related protein Rab-8A/0.599
3lbiGNPGTPase HRas/0.597
3oiuGNPGTPase HRas/0.596
3ddcGNPGTPase HRas/0.595
3lbhGNPGTPase HRas/0.592
3rs4GNPGTPase HRas/0.592
4g0nGNPGTPase HRas/0.590
5b2zGNPGTPase HRas/0.589
4nyiGNPGTPase HRas/0.583
2rgbGNPGTPase HRas/0.582
4dlzGNPGTPase HRas/0.581
3pitGNPRas-related protein M-Ras/0.576
4k81GTPGTPase HRas/0.573
4qxaGTPRas-related protein Rab-9A/0.562
4nyjGNPGTPase HRas/0.561
2zetGTPRas-related protein Rab-27B/0.559
3kucGDPRas-related protein Rap-1A/0.555
4dlxGNPGTPase HRas/0.555
4mitGTPRho-related protein racC/0.554
3a6pGTPGTP-binding nuclear protein Ran/0.553
3l8yGNPGTPase HRas/0.553
1g17GNPRas-related protein SEC4/0.552
3tsoGNPRas-related protein Rab-25/0.550
2gilGTPRas-related protein Rab-6A/0.549
3oesGNPGTPase RhebL1/0.549
3kkoGNPRas-related protein M-Ras/0.546
3rabGNPRas-related protein Rab-3A/0.546
3x1zGNPRas-related protein Rap-1b/0.546
3rslGNPGTPase HRas/0.544
4dlvGNPGTPase HRas/0.544
1xtsGTPGTP-binding protein Rheb/0.543
4cymGCPRas-related protein Rab-32/0.542
1zbdGTPRas-related protein Rab-3A/0.541
4dsnGCPGTPase KRas/0.536
2c5lGTPGTPase HRas/0.534
3bbpGTPRas-related protein Rab-6A/0.534
1t91GTPRas-related protein Rab-7a/0.532
1yzqGNPRas-related protein Rab-6A/0.532
5dhaGNPGTP-binding nuclear protein Ran/0.532
1xtrGNPGTP-binding protein Rheb/0.530
4rkfGNPRas-related protein Rab-3/0.530
1e96GTPRas-related C3 botulinum toxin substrate 1/0.527
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.527
3e5hGNPRas-related protein Rab-28/0.527
1kmqGNPTransforming protein RhoA/0.520
3a58GNPGTP-binding protein RHO1/0.520
3lawGNPRas-related protein Rab-7a/0.520
3w3zGTPGTP-binding nuclear protein Ran/0.520
4o25GTPGTP-binding protein Rheb/0.519
4l9wGNPGTPase HRas/0.516
5jljGNPGTP-binding nuclear protein Ran/0.513
4hdoGNPRas-related protein Rap-1b/0.512
4ol0GTPGTP-binding nuclear protein Ran/0.512
1zc3GNPRas-related protein Ral-A/0.511
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.511
3nbzGTPGTP-binding nuclear protein Ran/0.510
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.510
3tnfGNPRas-related protein Rab-8A/0.510
1yhnGTPRas-related protein Rab-7a/0.508
1cxzGSPTransforming protein RhoA/0.507
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.506
3ea5GDPGTP-binding nuclear protein Ran/0.506
1zc4GNPRas-related protein Ral-A/0.505
3oiwGNPGTPase HRas/0.505
4dlsGNPGTPase HRas/0.504
4uj3GNPRas-related protein Rab-11A/0.504
3wyfGTPGTP-binding nuclear protein/0.503
1m7bGTPRho-related GTP-binding protein RhoE/0.500
4kvgGTPRas-related protein Rap-1A/0.498
1oixGDPRas-related protein Rab-11A/0.497
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.496
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.495
1zd9GDPADP-ribosylation factor-like protein 8A/0.493
2fe4GDPRas-related protein Rab-6B/0.491
3eg5GNPCell division control protein 42 homolog/0.491
3tklGTPRas-related protein Rab-1A/0.491
3kudGDPGTPase HRas/0.490
5difGNPGTP-binding nuclear protein Ran/0.487
5hpyGDPTransforming protein RhoA/0.487
2ffqGSPRas-related protein Rab-6B/0.486
2bkuGTPGTP-binding nuclear protein Ran/0.485
3bc1GNPRas-related protein Rab-27A/0.485
1vg8GNPRas-related protein Rab-7a/0.484
1ibrGNPGTP-binding nuclear protein Ran/0.481
4xoiGTPTransforming protein RhoA/0.479
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.476
2cl6CAGGTPase HRas/0.475
3cphGDPRas-related protein SEC4/0.472
1ow3GDPTransforming protein RhoA/0.471
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.469
1a2bGSPTransforming protein RhoA/0.466
1lfdGNPGTPase HRas/0.465
2gcpGSPRho-related GTP-binding protein RhoC/0.465
3kz1GSPTransforming protein RhoA/0.465
4js0GNPCell division control protein 42 homolog/0.464
1k5dGNPGTP-binding nuclear protein Ran/0.463
2rggGNPGTPase HRas/0.460
3qbtGNPRas-related protein Rab-8A/0.460
3tgpGNPGTPase HRas/0.460
4lpkGDPGTPase KRas/0.460
4tq9GDPGTPase KRas/0.460
1uadGNPRas-related protein Ral-A/0.459
1yu9GNPRas-related protein Rab-4A/0.459
4hdqGNPRas-related protein Rap-1b/0.459
4l9sGDPGTPase HRas/0.456
4o2lGTPGTP-binding protein Rheb/0.456
1n6lGTPRas-related protein Rab-5A/0.453
4dxaGSPRas-related protein Rap-1b/0.453
5c46GSPRas-related protein Rab-11A/0.452
4uj5GNPRas-related protein Rab-11A/0.451
1s1cGNPTransforming protein RhoA/0.448
4lv6GDPGTPase KRas/0.448
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.444
1z0aGDPRas-related protein Rab-2A/0.443
4xvrGNPGTPase HRas/0.441
1eioGCHGastrotropin/0.440