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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3l8sBFFMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3l8sBFFMitogen-activated protein kinase 14/1.000
3lfeZ84Mitogen-activated protein kinase 14/0.537
4eh50OMMitogen-activated protein kinase 14/0.516
2ewaSB2Mitogen-activated protein kinase 14/0.509
1ouy094Mitogen-activated protein kinase 14/0.499
3iw8HIZMitogen-activated protein kinase 14/0.491
1bl7SB4Mitogen-activated protein kinase 14/0.490
4dlj6RGMitogen-activated protein kinase 14/0.488
3zsh469Mitogen-activated protein kinase 14/0.486
3gcq1BUMitogen-activated protein kinase 14/0.485
3hv3R49Mitogen-activated protein kinase 14/0.484
3gc9B45Mitogen-activated protein kinase 112.7.11.240.477
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.477
4eh60ONMitogen-activated protein kinase 14/0.477
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.477
2po7CHDFerrochelatase, mitochondrial4.99.1.10.475
1bl6SB6Mitogen-activated protein kinase 14/0.473
2uxoTACHTH-type transcriptional regulator TtgR/0.473
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.472
1ouk084Mitogen-activated protein kinase 14/0.468
1m7qDQOMitogen-activated protein kinase 14/0.464
2bakAQZMitogen-activated protein kinase 14/0.464
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.464
4a9yAQZMitogen-activated protein kinase 14/0.464
4nb6444Nuclear receptor ROR-gamma/0.464
4ips1G4Mycocyclosin synthase1.14.21.90.463
1ove358Mitogen-activated protein kinase 14/0.462
4eh3NARMitogen-activated protein kinase 14/0.460
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.459
4eh70OOMitogen-activated protein kinase 14/0.459
1k6tXN1Gag-Pol polyprotein3.4.23.160.458
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.457
1uyePU9Heat shock protein HSP 90-alpha/0.456
3iw5DF3Mitogen-activated protein kinase 14/0.455
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.455
2uxhQUEHTH-type transcriptional regulator TtgR/0.454
1k6pXN3Gag-Pol polyprotein3.4.23.160.453
3p3zP3ZPutative cytochrome P450/0.453
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.453
4r20AERCytochrome P450 family 17 polypeptide 2/0.453
2jn3JN3Fatty acid-binding protein, liver/0.452
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.452
3mdvCL6Cholesterol 24-hydroxylase/0.452
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4jlj1NMDeoxycytidine kinase2.7.1.740.451
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.450
3gc7B45Mitogen-activated protein kinase 14/0.450
5bt42LOBromodomain-containing protein 4/0.450
1zhzERGOxysterol-binding protein homolog 4/0.449
1uy6PU3Heat shock protein HSP 90-alpha/0.448
3itzP66Mitogen-activated protein kinase 14/0.448
3uibSB2Putative mitogen-activated protein kinase/0.448
4ia1BIVVitamin D3 receptor A/0.448
1uymPU3Heat shock protein HSP 90-beta/0.447
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.447
3p99LNPLanosterol 14-alpha-demethylase/0.447
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.447
1xddAAYIntegrin alpha-L/0.446
2jedLG8Protein kinase C theta type2.7.11.130.446
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
3r9uFADThioredoxin reductase/0.446
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
1jioDEB6-deoxyerythronolide B hydroxylase/0.445
1sn5T3Transthyretin/0.445
1uy7PU4Heat shock protein HSP 90-alpha/0.445
3ua506XCytochrome P450 2B61.14.130.444
4v12POGMaoC like domain protein/0.444
1fmlRTLRetinol dehydratase/0.443
2fwyH64Heat shock protein HSP 90-alpha/0.443
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.443
3reyXACAdenosine receptor A2a/0.443
1q5dEPBEpothilone C/D epoxidase1.140.442
3iw6PP0Mitogen-activated protein kinase 14/0.442
3vtcTK3Vitamin D3 receptor/0.442
3vtdTKDVitamin D3 receptor/0.442
4q73FADBifunctional protein PutA/0.442
1pkfEPDEpothilone C/D epoxidase1.140.441
3abaFLICytochrome P450/0.441
3mdmFJZCholesterol 24-hydroxylase/0.441
3vtbTKAVitamin D3 receptor/0.441
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.441
1rf9DBRCamphor 5-monooxygenase1.14.15.10.440
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.440
2hb7O1CVitamin D3 receptor/0.440
2om9AJAPeroxisome proliferator-activated receptor gamma/0.440
3fkoFKOMitogen-activated protein kinase 14/0.440
3iqfE4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.440
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.440