scPDB - Distribution of Binding site Similarity values of 3l3r entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3l3r	OAG	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	1.000
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.607
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.603
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.603
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.597
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.593
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.586
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.586
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.573
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.571
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.570
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.569
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.559
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.556
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.551
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.545
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.544
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.540
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.536
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.536
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.534
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.532
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.531
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.528
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.527
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.526
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.523
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.522
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.517
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.516
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.512
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.507
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.506
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.504
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.503
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.502
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.502
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.496
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.495
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.494
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.494
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.493
3qly	55V	Uncharacterized protein	/	0.491
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.489
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.489
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.488
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.486
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.485
3qlz	QLZ	Uncharacterized protein	/	0.483
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.481
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.479
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.477
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.475
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.473
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.473
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.471
3qlx	QLR	Uncharacterized protein	/	0.471
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.470
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.469
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.466
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.465
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.464
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.464
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.463
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.463
3eej	53R	Uncharacterized protein	/	0.462
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.462
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.459
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.459
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.459
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.458
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.457
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.457
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.457
3cse	N22	Uncharacterized protein	/	0.456
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.456
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.456
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.455
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.455
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.455
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.454
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.454
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.454
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.453
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.453
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.453
3eek	53S	Uncharacterized protein	/	0.451
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.450
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.449
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.449
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.449
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.448
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.447
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.447
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.447
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.446
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.444
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.443
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.443
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.442
2zza	FOL	Dihydrofolate reductase	/	0.442
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.441
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
3eem	53V	Uncharacterized protein	/	0.441
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.441
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.441
1w06	W05	Isopenicillin N synthase	1.21.3.1	0.440
2vbd	V10	Isopenicillin N synthase	1.21.3.1	0.440