sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3kds | NHX | ATP-dependent zinc metalloprotease FtsH |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3kds | NHX | ATP-dependent zinc metalloprotease FtsH | / | 1.000 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.467 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.466 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.462 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.456 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.456 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.455 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.455 | |
| 4wso | NAD | Probable nicotinate-nucleotide adenylyltransferase | / | 0.455 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.453 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.452 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.452 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.450 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.449 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.449 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.449 | |
| 3wdl | ATP | 4-phosphopantoate--beta-alanine ligase | 6.3.2.36 | 0.449 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.448 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.448 | |
| 4qec | NAP | ElxO | / | 0.448 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.447 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.447 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.445 | |
| 2h3w | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.444 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.444 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.443 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.442 | |
| 3nbv | ANP | Ketohexokinase | / | 0.442 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.441 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4qed | NAP | ElxO | / | 0.440 |