sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3k98 | 1RC | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.584 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.559 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.555 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.555 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.549 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.549 | |
| 1u0z | RDC | Endoplasmin | / | 0.547 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.546 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.540 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.536 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.536 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.536 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.534 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.531 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.531 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.530 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.530 | |
| 1u0y | PA7 | Endoplasmin | / | 0.529 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.526 | |
| 1qy8 | RDI | Endoplasmin | / | 0.523 | |
| 1ysz | NEC | Endoplasmin | / | 0.523 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.523 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.523 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 1u2o | NEC | Endoplasmin | / | 0.519 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.518 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.518 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.516 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.516 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.514 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.514 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.511 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.511 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.509 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.508 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.507 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.506 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.504 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.503 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.501 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.500 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.500 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.498 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.497 | |
| 1qy5 | NEC | Endoplasmin | / | 0.496 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.496 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 2exl | GDM | Endoplasmin | / | 0.491 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.491 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 2gqp | PA7 | Endoplasmin | / | 0.487 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.486 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.485 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.484 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.483 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.483 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.483 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.482 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 2hch | N5A | Endoplasmin | / | 0.481 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 3ied | AN2 | HSP90 | / | 0.480 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.477 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.473 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.472 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.469 | |
| 2fyp | RDE | Endoplasmin | / | 0.469 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.467 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.466 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.463 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.463 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.461 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.460 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.459 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.457 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.457 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.457 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.457 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 2esa | GDM | Endoplasmin | / | 0.456 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.454 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.453 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.453 | |
| 3rlp | 3RP | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.452 | |
| 2xhx | T5M | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 2yi7 | BZ8 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.451 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.451 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.450 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.449 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2vnh | FAD | NADPH:ferredoxin reductase | / | 0.449 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 2o1u | ANP | Endoplasmin | / | 0.448 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.448 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.447 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.447 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.446 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.445 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.445 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.445 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.444 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.443 | |
| 2hg1 | N5O | Endoplasmin | / | 0.443 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.443 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.442 | |
| 2fum | MIX | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.442 | |
| 2xjg | XJG | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.441 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.441 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.440 |