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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3k5uPFQAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3k5uPFQAurora kinase A2.7.11.11.000
5l8lADPAurora kinase A2.7.11.10.558
4c3rACPAurora kinase A2.7.11.10.552
4deaNHIAurora kinase A2.7.11.10.539
2wqeADPAurora kinase A2.7.11.10.536
2w1fL0FAurora kinase A2.7.11.10.533
4jboWPHAurora kinase A2.7.11.10.530
5drdATPAurora kinase A2.7.11.10.530
2w1gL0GAurora kinase A2.7.11.10.525
3efwAK8Aurora kinase A2.7.11.10.525
4jbpYPHAurora kinase A2.7.11.10.523
5dt4ATPAurora kinase A2.7.11.10.522
4o0wADNAurora kinase A2.7.11.10.521
4o0uADNAurora kinase A2.7.11.10.520
3w18N13Aurora kinase A2.7.11.10.514
4deeADPAurora kinase A2.7.11.10.514
4c3pACPAurora kinase A2.7.11.10.510
4jajXU1Aurora kinase A2.7.11.10.508
2dwbANPAurora kinase A2.7.11.10.506
4jbqVX6Aurora kinase A2.7.11.10.504
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.503
5dosATPAurora kinase A2.7.11.10.503
5dt3ATPAurora kinase A2.7.11.10.495
1ol5ADPAurora kinase A2.7.11.10.492
5dr9SKEAurora kinase A2.7.11.10.490
3w16P9JAurora kinase A2.7.11.10.485
2np8CC3Aurora kinase A2.7.11.10.484
2xneASHAurora kinase A2.7.11.10.484
5dpvSKEAurora kinase A2.7.11.10.481
2xru400Aurora kinase A2.7.11.10.478
1mq4ADPAurora kinase A2.7.11.10.477
3ttiKBIMitogen-activated protein kinase 102.7.11.240.476
1pmn984Mitogen-activated protein kinase 102.7.11.240.475
5dr2ATPAurora kinase A2.7.11.10.468
2ijmATPFocal adhesion kinase 12.7.10.20.467
4utdACPAurora kinase A2.7.11.10.467
5dnrATPAurora kinase A2.7.11.10.465
2w1eL0EAurora kinase A2.7.11.10.464
3ttjJBIMitogen-activated protein kinase 102.7.11.240.462
5dn3ATPAurora kinase A2.7.11.10.462
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.457
5dr6SKEAurora kinase A2.7.11.10.457
2xngA0HAurora kinase A2.7.11.10.455
2bmcMPYAurora kinase A2.7.11.10.454
3cgfJNFMitogen-activated protein kinase 102.7.11.240.454
3uo50BXAurora kinase A2.7.11.10.454
1bygSTUTyrosine-protein kinase CSK/0.453
3t8oATPRhodopsin kinase/0.453
3v4tUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.453
5l8kADPAurora kinase A2.7.11.10.453
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.452
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.452
5dt0SKEAurora kinase A2.7.11.10.452
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.451
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.451
4b0gVEKAurora kinase A2.7.11.10.450
1ol7ADPAurora kinase A2.7.11.10.449
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.449
2j4z626Aurora kinase A2.7.11.10.448
2excJNKMitogen-activated protein kinase 102.7.11.240.447
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.447
2x6dX6DAurora kinase A2.7.11.10.447
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
2bfyH1NAurora kinase B-A2.7.11.10.446
3nbvANPKetohexokinase/0.446
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.445
4k33ACPFibroblast growth factor receptor 32.7.10.10.445
2b1pAIZMitogen-activated protein kinase 102.7.11.240.444
3ztxZTXAurora kinase B-A2.7.11.10.444
3issEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.443