scPDB - Distribution of Binding site Similarity values of 3k47 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3k47	D09	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3k47	D09	Dihydrofolate reductase	1.5.1.3	1.000
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.606
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.604
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.596
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.586
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.584
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.583
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.570
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.558
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.556
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.555
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.545
4qjc	IXE	Dihydrofolate reductase	1.5.1.3	0.538
1dlr	MXA	Dihydrofolate reductase	1.5.1.3	0.534
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.533
1dr4	HBI	Dihydrofolate reductase	1.5.1.3	0.526
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.526
3cse	N22	Uncharacterized protein	/	0.526
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.525
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.520
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.519
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.518
3eek	53S	Uncharacterized protein	/	0.507
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.506
4h98	14Q	Uncharacterized protein	/	0.504
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.502
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.502
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.502
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.502
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.500
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.500
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.497
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.496
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.495
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.495
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.494
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.493
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.493
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.489
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.487
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.486
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.485
3qly	55V	Uncharacterized protein	/	0.485
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.484
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.483
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.483
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.482
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.481
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.480
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.480
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.479
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.478
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.478
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.477
3eej	53R	Uncharacterized protein	/	0.475
3eel	53T	Uncharacterized protein	/	0.475
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.475
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.474
3qlz	QLZ	Uncharacterized protein	/	0.474
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.472
3eem	53V	Uncharacterized protein	/	0.472
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.471
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.471
3qlx	QLR	Uncharacterized protein	/	0.471
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.468
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.467
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.466
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.466
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.466
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.466
2y98	MIV	Mycinamicin IV hydroxylase/epoxidase	/	0.465
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.464
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.464
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.464
1upw	444	Oxysterols receptor LXR-beta	/	0.463
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.463
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.463
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.462
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.461
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.460
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.459
1pkf	EPD	Epothilone C/D epoxidase	1.14	0.457
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.457
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.457
2y1o	T26	UDP-N-acetylmuramoylalanine--D-glutamate ligase	6.3.2.9	0.457
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.457
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.456
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.456
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.455
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.454
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.454
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.454
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
3ezp	B3N	Histone deacetylase 8	3.5.1.98	0.454
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.454
3qm4	PN0	Cytochrome P450 2D6	/	0.453
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
3njo	PYV	Abscisic acid receptor PYR1	/	0.451
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.450
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.450
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.448
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.448
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.447
3o56	ZG1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.447
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.446
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.446
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.445
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.445
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.445
3i8a	N22	Dihydrofolate reductase	1.5.1.3	0.445
3p9t	TCL	Repressor	/	0.445
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.444
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.444
4c1i	EH9	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.444
4j6c	STR	Cytochrome P450 monooxygenase	/	0.444
4qa0	SHH	Histone deacetylase 8	3.5.1.98	0.444
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.443
4i6h	1C8	Serine/threonine-protein kinase PLK2	2.7.11.21	0.443
4qa2	SHH	Histone deacetylase 8	3.5.1.98	0.443
4hf4	15H	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.442
4rbs	0RV	Metallo-beta-lactamase type 2	/	0.441