scPDB - Distribution of Binding site Similarity values of 3k45 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3k45	51P	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3k45	51P	Dihydrofolate reductase	1.5.1.3	1.000
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.620
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.595
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.584
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.580
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.576
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.565
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.564
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.562
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.561
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.558
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.551
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.551
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.549
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.547
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.546
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.546
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.542
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.540
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.538
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.537
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.536
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.535
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.534
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.530
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.530
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.529
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.528
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.527
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.527
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.525
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.524
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.524
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.524
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.516
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.499
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.497
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.497
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.495
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.495
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.490
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.486
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.483
1yho	TRR	Dihydrofolate reductase	1.5.1.3	0.482
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.479
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.475
3cse	N22	Uncharacterized protein	/	0.475
3nxo	D2B	Dihydrofolate reductase	1.5.1.3	0.474
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.473
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.469
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.468
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.468
3qly	55V	Uncharacterized protein	/	0.467
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.467
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.466
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.461
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.459
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.459
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.456
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.456
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.456
3nxy	D2H	Dihydrofolate reductase	1.5.1.3	0.456
4b11	7I1	Glycylpeptide N-tetradecanoyltransferase	/	0.456
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.454
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.454
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.453
1q0z	AKA	Aclacinomycin methylesterase RdmC	3.1.1.95	0.452
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.452
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.452
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.452
3qlx	QLR	Uncharacterized protein	/	0.448
1pkf	EPD	Epothilone C/D epoxidase	1.14	0.447
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.446
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.446
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.446
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.445
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.445
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.444
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.443
1ejb	INJ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.441
1oc1	ASV	Isopenicillin N synthase	1.21.3.1	0.441
1s7g	NAD	NAD-dependent protein deacylase 2	/	0.441
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.441
3p9t	TCL	Repressor	/	0.441
3eem	53V	Uncharacterized protein	/	0.440