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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.660
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.651
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.642
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.635
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.635
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.626
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.623
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.615
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.611
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.608
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.597
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.596
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.584
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.583
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.582
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.574
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.569
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.552
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.520
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.489
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.479
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.466
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.462
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.459
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
4phlPILPhosphodiesterase/0.450
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3v94WYQPhosphodiesterase/0.444
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440