sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3jqc | JU2 | Pteridine reductase, putative |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3jqc | JU2 | Pteridine reductase, putative | / | 1.000 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.651 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.647 | |
| 3jq7 | DX2 | Pteridine reductase, putative | / | 0.647 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.646 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.636 | |
| 3jqb | DX6 | Pteridine reductase, putative | / | 0.631 | |
| 3jq9 | AX1 | Pteridine reductase, putative | / | 0.629 | |
| 3jqg | AX6 | Pteridine reductase, putative | / | 0.618 | |
| 3bmq | AX5 | Pteridine reductase | / | 0.609 | |
| 2yhu | WHF | Pteridine reductase | / | 0.608 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.604 | |
| 2wd7 | VGD | Pteridine reductase | / | 0.587 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.577 | |
| 3bmn | AX3 | Pteridine reductase | / | 0.577 | |
| 2x9g | LYA | Pteridine reductase | / | 0.560 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.559 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.554 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.553 | |
| 2x9n | AX3 | Pteridine reductase | / | 0.550 | |
| 3bmc | FOL | Pteridine reductase | / | 0.547 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.546 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.545 | |
| 3mcv | MCV | Pteridine reductase | / | 0.545 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.538 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.537 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.536 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.533 | |
| 1giq | NAI | Iota toxin component Ia | / | 0.528 | |
| 1e7w | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.526 | |
| 2qhx | FE1 | Pteridine reductase 1 | 1.5.1.33 | 0.526 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.526 | |
| 4k37 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.522 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.521 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.520 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.520 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.518 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.518 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.517 | |
| 4bdr | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.517 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.515 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.514 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.513 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.511 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.509 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.509 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.508 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.508 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.506 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.504 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.502 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.502 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.502 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.501 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.501 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.501 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.500 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3roe | THM | NAD(P)H-hydrate epimerase | 5.1.99.6 | 0.499 | |
| 4b6l | 9ZP | Serine/threonine-protein kinase PLK3 | 2.7.11.21 | 0.499 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.498 | |
| 2qvd | BER | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.497 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.497 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.496 | |
| 4bwa | N0B | Pyrrolysine--tRNA ligase | / | 0.496 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.495 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.495 | |
| 3i58 | 7NA | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.494 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.494 | |
| 2isc | 223 | Purine nucleoside phosphorylase, putative | / | 0.491 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.491 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.490 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.489 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.489 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.489 | |
| 4hqv | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.489 | |
| 4k36 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.489 | |
| 4zqm | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.489 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.488 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.488 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.487 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.485 | |
| 4rtb | SAM | Putative thiazole biosynthesis protein ThiH | / | 0.485 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.484 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.482 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.482 | |
| 4fps | 0UX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.482 | |
| 4gh1 | 0WX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.482 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.481 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3htj | ET | EbrA repressor | / | 0.480 | |
| 2oth | NIM | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.479 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.479 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.479 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.478 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.478 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.478 | |
| 3r94 | FLR | Aldo-keto reductase family 1 member C3 | / | 0.478 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.478 | |
| 1pke | 2FD | Purine nucleoside phosphorylase DeoD-type | / | 0.477 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.477 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.477 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.477 | |
| 4ts9 | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.477 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.476 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.476 | |
| 4hmb | PZZ | Phospholipase A2 VRV-PL-VIIIa | / | 0.476 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.475 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.475 | |
| 3n76 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.475 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.475 | |
| 4bdo | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.475 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1xmm | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.474 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.474 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.474 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.474 | |
| 4f0f | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.474 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.473 | |
| 1kts | C24 | Prothrombin | 3.4.21.5 | 0.473 | |
| 1uhh | CZP | Aequorin-2 | / | 0.473 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.473 | |
| 3bld | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.473 | |
| 3fow | IMH | Purine nucleoside phosphorylase | / | 0.473 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.473 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.473 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.473 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.473 | |
| 1k9s | FM1 | Purine nucleoside phosphorylase DeoD-type | / | 0.472 | |
| 1zvl | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.472 | |
| 2cje | DUN | DUTPase | / | 0.472 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.472 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.472 | |
| 4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.472 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.472 | |
| 1jdv | ADN | Purine nucleoside phosphorylase | / | 0.471 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.471 | |
| 3anl | SYC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.471 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.471 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.471 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.471 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.471 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.471 | |
| 1a69 | FMB | Purine nucleoside phosphorylase DeoD-type | / | 0.470 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.470 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.470 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.470 | |
| 3nhr | RZW | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.470 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.469 | |
| 1fdk | GLE | Phospholipase A2 | 3.1.1.4 | 0.469 | |
| 1ltz | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.469 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.469 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.468 | |
| 2xjc | 5GP | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.468 | |
| 3arv | SAU | Chitinase A | / | 0.468 | |
| 3jta | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.468 | |
| 3lfz | ADP | Uncharacterized protein MJ1225 | / | 0.468 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.468 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.467 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.467 | |
| 1krv | 147 | Galactoside O-acetyltransferase | 2.3.1.18 | 0.467 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.467 | |
| 2xxv | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.467 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.467 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
| 4jsg | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.467 | |
| 4k39 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.467 | |
| 5dn1 | AMZ | Phosphoribosyl isomerase A | 5.3.1.16 | 0.467 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.467 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1el4 | CTZ | Obelin | / | 0.466 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.466 | |
| 2lbd | REA | Retinoic acid receptor gamma | / | 0.466 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.466 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3p9t | TCL | Repressor | / | 0.466 | |
| 3wzn | BTN | Streptavidin | / | 0.466 | |
| 4trj | 665 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.465 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
| 1pr6 | XYA | Purine nucleoside phosphorylase DeoD-type | / | 0.464 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.464 | |
| 1uze | EAL | Angiotensin-converting enzyme | 3.2.1 | 0.464 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.464 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.464 | |
| 2bf4 | FMN | NADPH--cytochrome P450 reductase | / | 0.464 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.464 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.464 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.464 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.463 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.463 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.463 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.463 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.463 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.463 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.463 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2d2g | DZZ | Phosphotriesterase | / | 0.462 | |
| 2v2q | NVG | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.462 | |
| 3nw2 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.462 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 5ckw | ANP | Uncharacterized protein | / | 0.462 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.462 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.461 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2gms | P0P | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.461 | |
| 3of3 | DIH | Purine nucleoside phosphorylase DeoD-type 1 | / | 0.461 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 4f1o | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.461 | |
| 4nqg | CZH | Mitrocomin | / | 0.461 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.460 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.460 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2vbv | FMN | Riboflavin kinase | 2.7.1.161 | 0.460 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.460 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.460 | |
| 4hfn | CIY | 2-alkenal reductase (NADP(+)-dependent) | / | 0.460 | |
| 4itx | IN5 | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.460 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.460 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.460 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.459 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.459 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.459 | |
| 1uhj | CZB | Aequorin-2 | / | 0.459 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.459 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2i4t | UA2 | Purine nucleoside phosphorylase, putative | / | 0.459 | |
| 2oli | IOP | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.459 | |
| 2vfz | UPF | N-acetyllactosaminide alpha-1,3-galactosyltransferase | / | 0.459 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.459 | |
| 4f79 | P53 | Putative phospho-beta-glucosidase | / | 0.459 | |
| 4imu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.459 | |
| 4xt8 | TMQ | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.459 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.459 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.459 | |
| 1qv0 | CZH | Obelin | / | 0.458 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.458 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.458 | |
| 1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.458 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.458 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2oyf | IAC | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.458 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.458 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.458 | |
| 3ba6 | AN2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.458 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.458 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.458 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.457 | |
| 1o23 | UPG | Beta-1,4-galactosyltransferase 1 | / | 0.457 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.457 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3p70 | ILE_PHE_GLU_PRO_PRO | Prothrombin | 3.4.21.5 | 0.457 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
| 4fvz | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.457 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.456 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.456 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.456 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.456 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.456 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.456 | |
| 3l9h | ADP | Kinesin-like protein KIF11 | / | 0.456 | |
| 3nfr | EWQ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.456 | |
| 4bub | ADP | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase | / | 0.456 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.456 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.456 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.456 | |
| 4zs4 | ATP | Myosin heavy chain kinase A | 2.7.11.7 | 0.456 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.456 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.456 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.455 | |
| 2j9g | ADP | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 2o8b | ADP | DNA mismatch repair protein Msh2 | / | 0.455 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.455 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.455 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.455 | |
| 3rl3 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.455 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.455 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.455 | |
| 4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.455 | |
| 4wbd | ADP | Putative cysteine ligase BshC | / | 0.455 | |
| 4gbr | CAU | Beta-2 adrenergic receptor | / | 0.455 | |
| 3ny9 | JSZ | Beta-2 adrenergic receptor | / | 0.455 | |
| 1i9h | BNI | Streptavidin | / | 0.454 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.454 | |
| 1zy5 | ANP | eIF-2-alpha kinase GCN2 | / | 0.454 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.454 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 3nhk | VAP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.454 | |
| 3sm0 | AEK | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.454 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.454 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.454 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.453 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.453 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.453 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.453 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.453 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.453 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.453 | |
| 4dkb | DUN | Deoxyuridine triphosphatase, putative | / | 0.453 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.453 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.453 | |
| 4mrx | CZH | Obelin | / | 0.453 | |
| 4uga | Q05 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.453 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.453 | |
| 1l2i | ETC | Estrogen receptor | / | 0.452 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.452 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 2j0v | GDP | Rac-like GTP-binding protein ARAC7 | / | 0.452 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.452 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
| 3nhf | VVV | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.452 | |
| 4isf | 1FX | Glucokinase | 2.7.1.2 | 0.452 | |
| 1je1 | GMP | Purine nucleoside phosphorylase | / | 0.451 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.451 | |
| 2oym | MNI | Endoglycoceramidase II | / | 0.451 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.451 | |
| 2x2r | ADP | Kinesin-like protein KIF11 | / | 0.451 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.451 | |
| 3akl | ADP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.451 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3ldg | SAH | Uncharacterized protein | / | 0.451 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 3tfn | 2CJ | Dehydrosqualene synthase | / | 0.451 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.451 | |
| 4dyn | 0MR | Nucleoprotein | / | 0.451 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.451 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.451 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.451 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.450 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.450 | |
| 2rtd | BTN | Streptavidin | / | 0.450 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.450 | |
| 3b3m | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 3kzo | AN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.450 | |
| 3p0e | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.450 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.450 | |
| 3zpq | XF5 | Beta-1 adrenergic receptor | / | 0.450 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.450 | |
| 4isu | IKM | Glutamate receptor 2 | / | 0.450 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.450 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.450 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.449 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 1r35 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.449 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.449 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.449 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.449 | |
| 2yye | APC | Selenide, water dikinase | 2.7.9.3 | 0.449 | |
| 3bt9 | DEQ | HTH-type transcriptional regulator QacR | / | 0.449 | |
| 3ebi | BEY | M1 family aminopeptidase | 3.4.11 | 0.449 | |
| 3l7g | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.449 | |
| 3n61 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.449 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4b5n | FMN | NAD(P)H:flavin oxidoreductase Sye4 | / | 0.449 | |
| 4gqk | ADP | Actin cross-linking toxin VgrG1 | / | 0.449 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.449 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4y6g | F6F | Tryptophan synthase alpha chain | / | 0.449 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.448 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
| 1jdt | MTA | Purine nucleoside phosphorylase | / | 0.448 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 1w29 | TS0 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1w2c | ANP | Inositol-trisphosphate 3-kinase A | 2.7.1.127 | 0.448 | |
| 1waj | 5GP | DNA-directed DNA polymerase | / | 0.448 | |
| 2izh | BTN | Streptavidin | / | 0.448 | |
| 2wgs | 1AZ | Glutamine synthetase | 6.3.1.2 | 0.448 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.448 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.448 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3p5s | AVU | CD38 molecule | / | 0.448 | |
| 4f97 | VDO | Putative glycosyltransferase | / | 0.448 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.448 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.447 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.447 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1qv1 | CZH | Obelin | / | 0.447 | |
| 1qzz | SAM | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.447 | |
| 1tsd | F89 | Thymidylate synthase | / | 0.447 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3bll | BPQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 3lzz | GDP | Uncharacterized protein | / | 0.447 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.447 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.447 | |
| 5d4v | YGP | Uncharacterized protein MJ0489 | / | 0.447 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.446 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1pxg | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.446 | |
| 2am2 | 2LG | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.446 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.446 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 3c10 | TSN | Histone deacetylase 7 | 3.5.1.98 | 0.446 | |
| 3nnz | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3ufo | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4cth | RDF | Neprilysin | / | 0.446 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.446 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.446 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.446 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.446 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.446 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.446 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.446 | |
| 5agl | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.446 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.446 | |
| 10mh | SAH | Modification methylase HhaI | 2.1.1.37 | 0.445 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.445 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.445 | |
| 1c1c | 612 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1k2u | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 2c9b | PUG | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.445 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.445 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.445 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.445 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.445 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3q99 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.445 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.445 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.445 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.445 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 1hp0 | AD3 | IAG-nucleoside hydrolase | / | 0.444 | |
| 1ne4 | RP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.444 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.444 | |
| 1pr0 | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.444 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.444 | |
| 1zyd | ATP | eIF-2-alpha kinase GCN2 | / | 0.444 | |
| 2acw | UPG | Glycosyltransferase | / | 0.444 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2b96 | ANN | Phospholipase A2 | 3.1.1.4 | 0.444 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.444 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.444 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3nlw | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.444 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4fw0 | 5KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.444 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.444 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.444 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1osv | CHC | Bile acid receptor | / | 0.443 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.443 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3ele | PLP | Aminotransferase | / | 0.443 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.443 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.443 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.443 | |
| 4gaa | BES | Leukotriene A(4) hydrolase | / | 0.443 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.443 | |
| 4jse | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 4l0o | PLP | Cystathionine gamma-synthase | 2.5.1.48 | 0.443 | |
| 4ol0 | GTP | GTP-binding nuclear protein Ran | / | 0.443 | |
| 4r09 | URI | Toll-like receptor 8 | / | 0.443 | |
| 4ug7 | 1EV | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.443 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.443 | |
| 5jr3 | 4MU | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.443 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.443 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.442 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.442 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.442 | |
| 1l0c | COT | Serotonin N-acetyltransferase | / | 0.442 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.442 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.442 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1yro | GDU | Beta-1,4-galactosyltransferase 1 | / | 0.442 | |
| 2b0q | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.442 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.442 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.442 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3phc | IM5 | Purine nucleoside phosphorylase | / | 0.442 | |
| 3ry2 | BTN | Streptavidin | / | 0.442 | |
| 4d2c | ALA_PHE | Di-or tripeptide:H+ symporter | / | 0.442 | |
| 4gda | BTN | Streptavidin | / | 0.442 | |
| 4gqe | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 4h38 | 0YX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.442 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4ork | GDP | Bifunctional AAC/APH | 2.3.1 | 0.442 | |
| 4ug9 | 1EW | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.442 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.441 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.441 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.441 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.441 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.441 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 2jav | 5Z5 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.441 | |
| 2vtb | MHF | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.441 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.441 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3q9a | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4dlc | UMP | Deoxyuridine triphosphatase, putative | / | 0.441 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.441 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.441 | |
| 4jui | EGR | Tannase | / | 0.441 | |
| 4l2g | 1V4 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2ycz | I32 | Beta-1 adrenergic receptor | / | 0.441 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.440 | |
| 1kru | IPT | Galactoside O-acetyltransferase | 2.3.1.18 | 0.440 | |
| 1oho | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1zp4 | C2F | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.440 | |
| 2esd | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.440 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.440 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2toh | HBI | Tyrosine 3-monooxygenase | 1.14.16.2 | 0.440 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.440 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2y88 | 2ER | Phosphoribosyl isomerase A | 5.3.1.16 | 0.440 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.440 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.440 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3lq2 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.440 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.440 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.440 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 0.440 | |
| 4iil | RBF | Membrane lipoprotein TpN38(b) | / | 0.440 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.440 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 4u0k | 744 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.440 |