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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3iw8HIZMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3iw8HIZMitogen-activated protein kinase 14/1.000
4eyjN61Mitogen-activated protein kinase 132.7.11.240.532
3gcsBAXMitogen-activated protein kinase 14/0.513
3ctj320Hepatocyte growth factor receptor2.7.10.10.467
3hv5R24Mitogen-activated protein kinase 14/0.467
4eevL1XHepatocyte growth factor receptor2.7.10.10.459
3lfbZ87Mitogen-activated protein kinase 14/0.458
3ce31FNHepatocyte growth factor receptor2.7.10.10.448
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.443
4o2z046Mitogen-activated protein kinase/0.443