scPDB - Distribution of Binding site Similarity values of 3inv entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	1.000
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.611
3eej	53R	Uncharacterized protein	/	0.591
3eek	53S	Uncharacterized protein	/	0.583
3qly	55V	Uncharacterized protein	/	0.579
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.578
4h98	14Q	Uncharacterized protein	/	0.576
3qlx	QLR	Uncharacterized protein	/	0.575
3eem	53V	Uncharacterized protein	/	0.563
3eel	53T	Uncharacterized protein	/	0.559
3cse	N22	Uncharacterized protein	/	0.553
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.547
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.546
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.539
3qlz	QLZ	Uncharacterized protein	/	0.538
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.536
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.535
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.535
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.535
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.531
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.527
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.526
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.523
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.522
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.521
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.521
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.521
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.520
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.517
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.511
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.509
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.508
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.506
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.506
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.504
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.504
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.503
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.500
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.499
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.498
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.497
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.496
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.495
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.493
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.492
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.485
2w3v	TOP	Dihydrofolate reductase	/	0.483
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.482
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.482
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.481
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.481
2zza	FOL	Dihydrofolate reductase	/	0.478
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.477
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.476
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.475
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.475
3ia4	MTX	Dihydrofolate reductase	/	0.472
4p66	MTX	Dihydrofolate reductase	/	0.472
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.471
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.469
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.468
3sa2	7DR	Dihydrofolate reductase	/	0.468
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.466
3jwm	5WB	Dihydrofolate reductase	/	0.466
3jwc	EKB	Dihydrofolate reductase	/	0.465
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.465
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.463
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.461
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.461
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.460
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.459
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.458
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.458
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.457
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.456
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.456
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.455
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.455
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.455
7dfr	FOL	Dihydrofolate reductase	1.5.1.3	0.454
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.453
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.453
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.453
3tq9	MTX	Dihydrofolate reductase	/	0.453
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.453
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.452
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.451
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.451
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.449
3sa1	6DR	Dihydrofolate reductase	/	0.449
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.449
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.448
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.448
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.448
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.446
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.446
1qzf	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.445
3jw5	TOP	Dihydrofolate reductase	/	0.445
2w3w	VG9	Dihydrofolate reductase	/	0.444
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.443
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.443
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.442
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.442
3sai	9DR	Dihydrofolate reductase	/	0.442
5hs1	VOR	Lanosterol 14-alpha demethylase	/	0.442
3frf	XCF	Dihydrofolate reductase	1.5.1.3	0.441
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.441
3tqb	FOL	Dihydrofolate reductase	/	0.440
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.440