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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3iifAPRCore histone macro-H2A.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3iifAPRCore histone macro-H2A.1/1.000
3iidAPRCore histone macro-H2A.1/0.572
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.518
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.480
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.472
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.467
2ylrFADPhenylacetone monooxygenase1.14.13.920.455
4mo2FADUDP-galactopyranose mutase/0.449
2nq8ZIDEnoyl-ACP reductase/0.446
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.444
5cb3APRO-acetyl-ADP-ribose deacetylase/0.443
2c0cNAPProstaglandin reductase 310.442