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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3iczPB6Farnesyl pyrophosphate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3iczPB6Farnesyl pyrophosphate synthase/1.000
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.593
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.100.593
3egt722Farnesyl pyrophosphate synthase/0.577
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.566
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.555
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.555
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.543
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.542
3dyh721Farnesyl pyrophosphate synthase/0.540
3rywK9HFarnesyl pyrophosphate synthase, putative/0.533
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.523
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.505
4bltAPCNTPase P4/0.467
1mjbACOHistone acetyltransferase ESA1/0.466
2oz57XYUncharacterized protein/0.465
3h86AP5Adenylate kinase/0.465
2xlrFADPutative flavin-containing monooxygenase/0.464
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.464
1w48APCNTPase P4/0.461
3ohh3HHBeta-secretase 13.4.23.460.460
5ej6TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.459
3p3c3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.456
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.456
1p8dCO1Oxysterols receptor LXR-beta/0.455
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.455
3f63GTXGlutathione transferase GST1-4/0.454
2ylzFADPhenylacetone monooxygenase1.14.13.920.452
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.452
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.452
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.451
4oaqNDPR-specific carbonyl reductase/0.451
1fy7COAHistone acetyltransferase ESA1/0.450
4bfvZVVPantothenate kinase2.7.1.330.450
3lpkZ76Beta-secretase 13.4.23.460.449
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.449
1yb5NAPQuinone oxidoreductase1.6.5.50.448
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.448
2f94BFQFarnesyl pyrophosphate synthase2.5.1.100.447
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
1psa0ZLPepsin A3.4.23.10.446
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.446
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.446
4hjfC2EGGDEF family protein/0.445
5esoISC2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.445
5irnADPNucleotide binding oligomerization domain containing 2/0.445
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.444
2q7vFADThioredoxin reductase/0.444
3krfDSTGeranyl diphosphate synthase large subunit/0.444
3oabDSTGeranyl diphosphate synthase large subunit/0.444
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.444
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.443
2z52H23Geranylgeranyl pyrophosphate synthase/0.443
1cbqRE9Cellular retinoic acid-binding protein 2/0.442
1tehNADAlcohol dehydrogenase class-31.1.1.10.442
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.442
2hog710Serine/threonine-protein kinase Chk12.7.11.10.442
2ylxFADPhenylacetone monooxygenase1.14.13.920.442
3uhmRFNUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.442
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.442
2q28ADPOxalyl-CoA decarboxylase4.1.1.80.441
4bfxZVXPantothenate kinase2.7.1.330.441
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.440
1rx1NAPDihydrofolate reductase1.5.1.30.440
4kcfAKMFAD-dependent oxidoreductase/0.440