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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.60

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.601.000
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.660
4gtt7TQGeranylgeranyl transferase type-2 subunit beta2.5.1.600.631
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.629
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.611
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.603
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.583
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.570
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.568
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.543
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.521
1ry8RUTAldo-keto reductase family 1 member C3/0.486
3n19FNRXenobiotic reductase/0.484
4h6pFMNChromate reductase/0.480
1pqc444Oxysterols receptor LXR-beta/0.474
4bfsZVSPantothenate kinase2.7.1.330.471
2y6fM9FIsopenicillin N synthase1.21.3.10.469
4uugPXGBranched-chain amino acid aminotransferase, putative/0.468
2cekN8TAcetylcholinesterase3.1.1.70.467
1s36CEIObelin/0.465
5stdUNNScytalone dehydratase4.2.1.940.464
4y0kNAPAntE/0.462
1blzACVIsopenicillin N synthase1.21.3.10.461
1obnASVIsopenicillin N synthase1.21.3.10.461
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.461
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.461
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.461
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.456
4cdmFO1Deoxyribodipyrimidine photolyase/0.456
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
4dbs0HVAldo-keto reductase family 1 member C3/0.455
2wo7ASVIsopenicillin N synthase1.21.3.10.454
2zsdCOAPantothenate kinase2.7.1.330.453
4e0u0MVCyclic dipeptide N-prenyltransferase/0.453
3zkyWT4Isopenicillin N synthase1.21.3.10.451
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.450
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.450
1u65CP0Acetylcholinesterase3.1.1.70.450
3n0hTOPDihydrofolate reductase1.5.1.30.450
4bfwZVWPantothenate kinase2.7.1.330.450
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.449
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.449
4y1bNAPAntE/0.449
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.448
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
4dk70KSOxysterols receptor LXR-beta/0.447
1tllFADNitric oxide synthase, brain1.14.13.390.446
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.446
2aj4ANPGalactokinase2.7.1.60.446
3af1GDPPantothenate kinase2.7.1.330.446
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.445
3zoiM2WIsopenicillin N synthase1.21.3.10.445
2w3mFOLDihydrofolate reductase1.5.1.30.444
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.444
4b2gV1NUncharacterized protein/0.444
4rvfTYDD-mycarose 3-C-methyltransferase/0.444
2dxiATPGlutamate--tRNA ligase6.1.1.170.443
3ntz3TZDihydrofolate reductase1.5.1.30.443
5iw5NMNNADH pyrophosphatase/0.443
1dhfFOLDihydrofolate reductase1.5.1.30.442
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.442
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.442
3h3r14HCollagen type IV alpha-3-binding protein/0.442
3q9bB3NAcetylpolyamine amidohydrolase/0.442
3rl45GPMetallophosphoesterase MPPED23.10.442
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.442
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.442
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.442
1q84TZ4Acetylcholinesterase3.1.1.70.441
1xf0ASDAldo-keto reductase family 1 member C3/0.441
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.441
3w6hAZMCarbonic anhydrase 14.2.1.10.441
2gevCOKPantothenate kinase2.7.1.330.440
2vrjNCWBeta-glucosidase A3.2.1.210.440
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440