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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hv5R24Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3hv5R24Mitogen-activated protein kinase 14/1.000
3kq7KQ7Mitogen-activated protein kinase 14/0.472
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.468
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.455
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.444
4aa0AA0Mitogen-activated protein kinase 14/0.442