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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hv4L51Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3hv4L51Mitogen-activated protein kinase 14/1.000
3gcuR48Mitogen-activated protein kinase 14/0.711
3uvr06FMitogen-activated protein kinase 14/0.520
3nnuEDBMitogen-activated protein kinase 14/0.509
3gcvSS6Mitogen-activated protein kinase 14/0.506
3npcB96Mitogen-activated protein kinase 92.7.11.240.506
1kv2B96Mitogen-activated protein kinase 14/0.486
1w82L10Mitogen-activated protein kinase 14/0.482
2yisYISMitogen-activated protein kinase 14/0.475
3lfbZ87Mitogen-activated protein kinase 14/0.469
3nnxEDDMitogen-activated protein kinase 14/0.466
4f7n0SVCyclin-dependent kinase 82.7.11.220.465
3nnwEDDMitogen-activated protein kinase 14/0.464
2puuG2GMitogen-activated protein kinase 14/0.462
1kv1BMUMitogen-activated protein kinase 14/0.459
3d83GK6Mitogen-activated protein kinase 14/0.459
3p7bP7BMitogen-activated protein kinase 14/0.455
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.451
1mp5UPGGlucose-1-phosphate thymidylyltransferase2.7.7.240.449
3e9319BMitogen-activated protein kinase 14/0.449
4kq2U5PGlycogen [starch] synthase isoform 22.4.1.110.448
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.446
3hv71AUMitogen-activated protein kinase 14/0.445
1wbtWBTMitogen-activated protein kinase 14/0.442
1wbsLI2Mitogen-activated protein kinase 14/0.440