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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hub469Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3hub469Mitogen-activated protein kinase 14/1.000
3fl4FL4Mitogen-activated protein kinase 14/0.599
1zzlTZYMitogen-activated protein kinase 14/0.597
3fkoFKOMitogen-activated protein kinase 14/0.594
3ds6A17Mitogen-activated protein kinase 14/0.584
3zsh469Mitogen-activated protein kinase 14/0.584
3fmmXI2Mitogen-activated protein kinase 14/0.581
3itzP66Mitogen-activated protein kinase 14/0.568
3fknFKNMitogen-activated protein kinase 14/0.567
2gfsPQBMitogen-activated protein kinase 14/0.563
2yixYIXMitogen-activated protein kinase 14/0.560
1ove358Mitogen-activated protein kinase 14/0.557
1wbwLI4Mitogen-activated protein kinase 14/0.555
3e92G6AMitogen-activated protein kinase 14/0.553
3lfeZ84Mitogen-activated protein kinase 14/0.526
1w7h3IPMitogen-activated protein kinase 14/0.524
3bx5304Mitogen-activated protein kinase 14/0.516
3c5uP41Mitogen-activated protein kinase 14/0.516
3rinI2OMitogen-activated protein kinase 14/0.512
3d7zGK5Mitogen-activated protein kinase 14/0.509
3iw6PP0Mitogen-activated protein kinase 14/0.509
3gc9B45Mitogen-activated protein kinase 112.7.11.240.508
3hp552PMitogen-activated protein kinase 14/0.507
3kf7L9GMitogen-activated protein kinase 14/0.507
3gc8B45Mitogen-activated protein kinase 112.7.11.240.503
1ouy094Mitogen-activated protein kinase 14/0.491
2zb1GK4Mitogen-activated protein kinase 14/0.490
3roc29AMitogen-activated protein kinase 14/0.490
3vtbTKAVitamin D3 receptor/0.489
3fc152PMitogen-activated protein kinase 14/0.487
3mpaSB2Mitogen-activated protein kinase 14/0.487
3iw5DF3Mitogen-activated protein kinase 14/0.485
4eh50OMMitogen-activated protein kinase 14/0.485
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.483
1m7qDQOMitogen-activated protein kinase 14/0.483
3pg3DG7Mitogen-activated protein kinase 14/0.482
1ywrLI9Mitogen-activated protein kinase 14/0.481
3hl7I47Mitogen-activated protein kinase 14/0.481
2qd9LGFMitogen-activated protein kinase 14/0.479
1zeoC01Peroxisome proliferator-activated receptor gamma/0.476
2uxoTACHTH-type transcriptional regulator TtgR/0.476
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.476
2gtmLIDMitogen-activated protein kinase 14/0.475
3bc3OPTCathepsin L13.4.22.150.475
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.474
3hng8STVascular endothelial growth factor receptor 12.7.10.10.474
4lb2DM5Serum albumin/0.474
1zyjBI5Mitogen-activated protein kinase 14/0.473
4l9q9TPSerum albumin/0.473
2z3uCRRCytochrome P450/0.472
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.472
1w83L11Mitogen-activated protein kinase 14/0.471
3flwFLWMitogen-activated protein kinase 14/0.471
3s4qNK0Mitogen-activated protein kinase 14/0.471
4y8wSTRSteroid 21-hydroxylase/0.471
3bv2P38Mitogen-activated protein kinase 14/0.470
3hllI45Mitogen-activated protein kinase 14/0.470
3iw7IPKMitogen-activated protein kinase 14/0.470
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.469
2po7CHDFerrochelatase, mitochondrial4.99.1.10.468
3o9zNADLipopolysaccaride biosynthesis protein wbpB/0.468
4ma628EAra h 8 allergen/0.468
4nieNBHNuclear receptor ROR-gamma/0.468
2q61SF1Peroxisome proliferator-activated receptor gamma/0.466
2zb0GK3Mitogen-activated protein kinase 14/0.466
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.466
3eigMTXDihydrofolate reductase1.5.1.30.465
3fmn530Mitogen-activated protein kinase 14/0.464
4b7xNAPProbable oxidoreductase/0.464
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.463
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.463
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.463
2znnS44Peroxisome proliferator-activated receptor alpha/0.463
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.463
3uvqFS8Mitogen-activated protein kinase 14/0.463
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.463
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.463
4xxvNAD3-isopropylmalate dehydrogenase/0.463
1yqj6NPMitogen-activated protein kinase 14/0.462
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.462
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.462
3flsFLSMitogen-activated protein kinase 14/0.462
3lu8IQXSerum albumin/0.462
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.461
3uibSB2Putative mitogen-activated protein kinase/0.461
3vtdTKDVitamin D3 receptor/0.461
3zuxTCHTransporter/0.461
4aa5NQBMitogen-activated protein kinase 14/0.461
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.460
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.460
3dt1P40Mitogen-activated protein kinase 14/0.459
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
3zsi52PMitogen-activated protein kinase 14/0.459
4lopSB4Mitogen-activated protein kinase 14/0.459
1yw2PGJMitogen-activated protein kinase 14/0.458
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.458
3flyFLYMitogen-activated protein kinase 14/0.458
1diuBDMDihydrofolate reductase1.5.1.30.457
1kzjCB3Thymidylate synthase/0.457
1qvnFRIInterleukin-2/0.457
3fmkFMKMitogen-activated protein kinase 14/0.457
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.457
4ib4ERM5-hydroxytryptamine receptor 2B/0.457
4klaCHDFerrochelatase, mitochondrial4.99.1.10.457
1osvCHCBile acid receptor/0.456
2bx8AZQSerum albumin/0.456
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.456
3eta351Insulin receptor2.7.10.10.456
3kytHC2Nuclear receptor ROR-gamma/0.456
4fhi0S4Vitamin D3 receptor A/0.456
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.455
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.455
3ha85JZMitogen-activated protein kinase 14/0.455
3p99LNPLanosterol 14-alpha-demethylase/0.455
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.455
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.454
3l0lHC3Nuclear receptor ROR-gamma/0.454
3vt9YI4Vitamin D3 receptor/0.454
3zuyTCHTransporter/0.454
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.453
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.453
4jx1CAHCamphor 5-monooxygenase1.14.15.10.453
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1k6pXN3Gag-Pol polyprotein3.4.23.160.452
1pmn984Mitogen-activated protein kinase 102.7.11.240.452
1synF89Thymidylate synthase/0.452
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.452
2ok7FADFerredoxin--NADP reductase, apicoplast/0.452
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.452
3p3zP3ZPutative cytochrome P450/0.452
4jtqNAPAldo-keto reductase family 1 member C2/0.452
5k2bZMAAdenosine receptor A2a/0.452
1tvrTB9Gag-Pol polyprotein2.7.7.490.451
2e0nSAHPrecorrin-2 C20-methyltransferase/0.451
3adaNADSubunit alpha of sarocosine oxidase/0.451
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.451
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
1jutLYDThymidylate synthase/0.450
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.450
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.450
2wleCOAPolysialic acid O-acetyltransferase/0.450
3bgxMEFThymidylate synthase/0.450
3fmjFMJMitogen-activated protein kinase 14/0.450
4eh70OOMitogen-activated protein kinase 14/0.450
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.450
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.450
5uviZMAAdenosine receptor A2a/0.450
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1ouk084Mitogen-activated protein kinase 14/0.449
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.449
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.449
4ia7BIVVitamin D3 receptor A/0.449
1nq7ARLNuclear receptor ROR-beta/0.448
1qcjAPTAntiviral protein I3.2.2.220.448
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.448
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.448
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
2rg6287Mitogen-activated protein kinase 14/0.448
3cv9VDXVitamin D3 dihydroxylase/0.448
3d7kD7KBenzaldehyde lyase/0.448
3iphG11Mitogen-activated protein kinase 14/0.448
3t1tGDPProbable gliding protein mglA/0.448
4elb34RDihydrofolate reductase/0.448
4i8vBHFCytochrome P450 1A11.14.14.10.448
1tduCB3Thymidylate synthase/0.447
1trgCB3Thymidylate synthase/0.447
1yb5NAPQuinone oxidoreductase1.6.5.50.447
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.447
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.447
3stv3HOMethylketone synthase I/0.447
3stxBKAMethylketone synthase I/0.447
3zkyWT4Isopenicillin N synthase1.21.3.10.447
4ku5DCC3-oxoacyl-[ACP] synthase III/0.447
4la0198Serum albumin/0.447
4loqSB4Mitogen-activated protein kinase 14/0.447
4uyf73BBromodomain-containing protein 2/0.447
5cdtPFBAlcohol dehydrogenase E chain1.1.1.10.447
5dozNDPJamJ/0.447
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2uxhQUEHTH-type transcriptional regulator TtgR/0.446
2y03Y01Beta-1 adrenergic receptor/0.446
2ydoADNAdenosine receptor A2a/0.446
3te4ACODopamine N-acetyltransferase/0.446
3zc3NAPFerredoxin--NADP reductase1.18.1.20.446
4b1fKRHGlutamate racemase/0.446
4ez8DHFThymidylate synthase2.1.1.450.446
1esvLARActin, alpha skeletal muscle/0.445
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.445
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1kk4ACOStreptogramin A acetyltransferase2.3.10.445
1re9DSOCamphor 5-monooxygenase1.14.15.10.445
1zhzERGOxysterol-binding protein homolog 4/0.445
2vcmM11Isopenicillin N synthase1.21.3.10.445
3atzFMNProstaglandin F2a synthase/0.445
3deiRXBCaspase-33.4.22.560.445
3jynNDPQuinone oxidoreductase/0.445
3nww3NWMitogen-activated protein kinase 14/0.445
3uleC69Actin-related protein 3/0.445
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4eh60ONMitogen-activated protein kinase 14/0.445
4gt3ATPMitogen-activated protein kinase 12.7.11.240.445
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.445
1fwmCB3Thymidylate synthase/0.444
1n4hREANuclear receptor ROR-beta/0.444
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2cig1DGDihydrofolate reductase1.5.1.30.444
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.444
3iw8HIZMitogen-activated protein kinase 14/0.444
3p6nDSOCamphor 5-monooxygenase1.14.15.10.444
4g1y0VOVitamin D3 receptor A/0.444
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.444
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.444
4mv1ADPBiotin carboxylase6.3.4.140.444
1bl6SB6Mitogen-activated protein kinase 14/0.443
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2ewaSB2Mitogen-activated protein kinase 14/0.443
3vrwYS5Vitamin D3 receptor/0.443
3vtcTK3Vitamin D3 receptor/0.443
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.443
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.443
4pd6URINucleoside permease/0.443
5cvfATPCasein kinase II subunit alpha2.7.11.10.443
2ath3EAPeroxisome proliferator-activated receptor gamma/0.442
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.442
3gcq1BUMitogen-activated protein kinase 14/0.442
3iupNDPPossible NADH oxidoreductase/0.442
3tqhNDPQuinone oxidoreductase/0.442
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4jlj1NMDeoxycytidine kinase2.7.1.740.442
4l8u9AZSerum albumin/0.442
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.442
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.442
4z9g1Q5Corticotropin-releasing factor receptor 1/0.442
3reyXACAdenosine receptor A2a/0.442
1ppjANYCytochrome b/0.441
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
2iviACWIsopenicillin N synthase1.21.3.10.441
2jfz003Glutamate racemase/0.441
2om9AJAPeroxisome proliferator-activated receptor gamma/0.441
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.441
3anmNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.441
3ekuCY9Actin-5C/0.441
3icrCOACoenzyme A disulfide reductase/0.441
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3slkNDPPolyketide synthase extender module 2/0.441
3w0c6DSVitamin D3 receptor/0.441
4iarERM5-hydroxytryptamine receptor 1B/0.441
4jbtASDCytochrome P450 monooxygenase/0.441
4o7uTHFThymidylate synthase/0.441
1bq1CB3Thymidylate synthase/0.440
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.440
1e6eFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.440
1jomFFODihydrofolate reductase1.5.1.30.440
1kkq471Peroxisome proliferator-activated receptor alpha/0.440
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1s6qTPBGag-Pol polyprotein2.7.7.490.440
1w06W05Isopenicillin N synthase1.21.3.10.440
1xkkFMMEpidermal growth factor receptor2.7.10.10.440
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.440
3b20NADGlyceraldehyde-3-phosphate dehydrogenase/0.440
3begANPSRSF protein kinase 12.7.11.10.440
3flzFLZMitogen-activated protein kinase 14/0.440
3fmh533Mitogen-activated protein kinase 14/0.440
3h1vTK1Glucokinase2.7.1.20.440
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.440
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.440
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4jx1CAMCamphor 5-monooxygenase1.14.15.10.440
4looSB4Mitogen-activated protein kinase 14/0.440
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.440