sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3hiv | TXN | rRNA N-glycosidase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3hiv | TXN | rRNA N-glycosidase | / | 1.000 | |
| 4mx1 | 1MX | Ricin | 3.2.2.22 | 0.519 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.504 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.500 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.497 | |
| 5ilw | URI | Ribosome inactivating protein | / | 0.497 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.496 | |
| 4h0v | NAD | Iota toxin component Ia | / | 0.495 | |
| 2b3v | ACO | Diamine acetyltransferase 1 | / | 0.494 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.493 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.492 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.490 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.489 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.489 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.488 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.487 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.487 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.486 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.486 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.484 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.480 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.480 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.480 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.480 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.480 | |
| 4id9 | NAD | Putative UDP-glucose 4-epimerase | / | 0.480 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.479 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.479 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.478 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.478 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.477 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.477 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.475 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.475 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.474 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.474 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.473 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.473 | |
| 1lpc | CMP | Antiviral protein DAP-30 | 3.2.2.22 | 0.472 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.472 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.472 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.472 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.472 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.470 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.470 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.470 | |
| 5c3a | URM | Histo-blood group ABO system transferase | / | 0.470 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.469 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.469 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.468 | |
| 1c7o | PPG | Hemolysin | / | 0.467 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.467 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.467 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.467 | |
| 2x92 | X92 | Angiotensin-converting enzyme | 3.4.15.1 | 0.467 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.467 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.467 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.467 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.466 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.466 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.466 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.466 | |
| 4lrl | TTP | HD domain protein | / | 0.466 | |
| 4tnp | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.466 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.465 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.465 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.465 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.465 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.465 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.464 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.464 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.463 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.463 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.463 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.463 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.463 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.463 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.462 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.462 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.462 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.462 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.461 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.461 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.461 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.461 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.461 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.461 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.461 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.460 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.460 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.459 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.459 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.459 | |
| 3kmc | 403 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.459 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.459 | |
| 4j7g | TRH | PCZA361.3 | / | 0.459 | |
| 4zgs | NAD | Putative D-lactate dehydrogenase | / | 0.459 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2bxo | OPB | Serum albumin | / | 0.458 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.458 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.458 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.458 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.458 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.458 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.458 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.458 | |
| 4d2d | ALA_ALA_ALA | Di-or tripeptide:H+ symporter | / | 0.458 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.458 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.458 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 1xjq | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.457 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.457 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.457 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3mo0 | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.457 | |
| 3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.457 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4lut | DCS | Alanine racemase | / | 0.457 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.457 | |
| 4n1g | CEI | Obelin | / | 0.457 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.456 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 2ejz | SAH | Diphthine synthase | / | 0.456 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.456 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.456 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.456 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.456 | |
| 1oxo | IK2 | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.455 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.455 | |
| 2r59 | PH0 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.455 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.455 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.455 | |
| 3wag | TYD | Glycosyltransferase | / | 0.455 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4e2y | JHZ | Methyltransferase | / | 0.455 | |
| 4hn1 | TYD | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.455 | |
| 1ahb | FMP | Ribosome-inactivating protein momordin I | 3.2.2.22 | 0.454 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.454 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.454 | |
| 3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.454 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.454 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.454 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.454 | |
| 4yp1 | 2BA | Stimulator of interferon genes protein | / | 0.454 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.453 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.453 | |
| 3oix | FMN | Dihydroorotate dehydrogenase | / | 0.453 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.453 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.453 | |
| 4d9f | DCS | D-cysteine desulfhydrase | / | 0.453 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.453 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.453 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.453 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.453 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.452 | |
| 1qf2 | TI3 | Thermolysin | 3.4.24.27 | 0.452 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.452 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.452 | |
| 2hp2 | KE4 | Glutamate-1-semialdehyde 2,1-aminomutase | 5.4.3.8 | 0.452 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2ydd | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.452 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.452 | |
| 3ckq | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.452 | |
| 3fuh | BES | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.452 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.452 | |
| 3w3l | RX8 | Toll-like receptor 8 | / | 0.452 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.452 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.452 | |
| 1k5d | GNP | GTP-binding nuclear protein Ran | / | 0.451 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.451 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.451 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.451 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3eku | CY9 | Actin-5C | / | 0.451 | |
| 3r96 | ACO | MccE protein | / | 0.451 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.451 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.451 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.451 | |
| 4tnz | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.451 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.450 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.450 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.450 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.450 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.450 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.450 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.450 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.450 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 4xg1 | LLP | Diaminopimelate decarboxylase | / | 0.450 | |
| 1n0s | FLU | Bilin-binding protein | / | 0.449 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.449 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.449 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.449 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2x95 | X95 | Angiotensin-converting enzyme | 3.4.15.1 | 0.449 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.449 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.449 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.449 | |
| 4m99 | ACO | UDP-N-acetylgalactosaminyltransferase | / | 0.449 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.449 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.449 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.449 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.449 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.448 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.448 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.448 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.448 | |
| 3eo8 | FMN | Putative nitroreductase | / | 0.448 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.448 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 4r7u | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.448 | |
| 5d4v | YGP | Uncharacterized protein MJ0489 | / | 0.448 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1j0b | 5PA | Putative 1-aminocyclopropane-1-carboxylate deaminase | 3.5.99.7 | 0.447 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.447 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.447 | |
| 1yki | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.447 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.447 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.447 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.447 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.447 | |
| 3hgg | CHD | CmeR | / | 0.447 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.447 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.447 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4bxk | 1IU | Angiotensin-converting enzyme | 3.2.1 | 0.447 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.447 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.447 | |
| 4to3 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.447 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.447 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 1og4 | NAI | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.446 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.446 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.446 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.446 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.446 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.446 | |
| 2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.446 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.446 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.446 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.446 | |
| 3ivx | FG6 | Pantothenate synthetase | 6.3.2.1 | 0.446 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.446 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3w3n | RX8 | Toll-like receptor 8 | / | 0.446 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.446 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.446 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.446 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.446 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.446 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.445 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.445 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.445 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.445 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.445 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.445 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.445 | |
| 3hl4 | CDC | Choline-phosphate cytidylyltransferase A | / | 0.445 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.445 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.445 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.445 | |
| 4iwn | GEK | Carboxy-S-adenosyl-L-methionine synthase | / | 0.445 | |
| 4l98 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.445 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.445 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.445 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.445 | |
| 1fxu | GU7 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.444 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.444 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.444 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.444 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.444 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.444 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.444 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4ca6 | 3EF | Angiotensin-converting enzyme | 3.2.1 | 0.444 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.444 | |
| 1by5 | GLY_GLY_GLY_AHO_AHO_AHO_FE | Ferrichrome-iron receptor | / | 0.443 | |
| 1jf0 | CZH | Obelin | / | 0.443 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.443 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.443 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.443 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.443 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.443 | |
| 2rhq | GAX | Phenylalanine--tRNA ligase alpha subunit | / | 0.443 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.443 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3eks | CY9 | Actin-5C | / | 0.443 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.443 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.443 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.443 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.443 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.443 | |
| 1kqf | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.442 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.442 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.442 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.442 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.442 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.442 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.442 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.442 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3bnk | FMN | Flavoredoxin | / | 0.442 | |
| 3d3x | ARG_ILE_MET_GLU_NH2 | Type E botulinum toxin | / | 0.442 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.442 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.442 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.442 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.442 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3vcy | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.442 | |
| 4e32 | DWN | Methyltransferase | / | 0.442 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.442 | |
| 4tnr | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.442 | |
| 13gs | SAS | Glutathione S-transferase P | 2.5.1.18 | 0.441 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.441 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.441 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1yry | MSG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2ft0 | ACO | dTDP-fucosamine acetyltransferase | / | 0.441 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.441 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3n76 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.441 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3u8f | FGM | Ribosome inactivating protein | / | 0.441 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.441 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.441 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.441 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.440 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.440 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 2ay3 | MPP | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.440 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.440 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2vou | FAD | 2,6-dihydroxypyridine 3-monooxygenase | 1.14.13.10 | 0.440 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.440 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.440 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.440 | |
| 4iae | 1DX | Alr2278 protein | / | 0.440 | |
| 4tln | LNO | Thermolysin | 3.4.24.27 | 0.440 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.440 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.440 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.440 |