sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3hav | ATP | Aminoglycoside phosphotransferase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3hav | ATP | Aminoglycoside phosphotransferase | / | 1.000 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.512 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.507 | |
| 4dca | ADP | Aminoglycoside phosphotransferase | / | 0.504 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.501 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.500 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.499 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.497 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.496 | |
| 3wnz | ADP | Alanine--anticapsin ligase | / | 0.495 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.495 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.493 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.492 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.490 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.490 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.489 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.489 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.486 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.486 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.485 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.485 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.484 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.484 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.484 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.483 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.483 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.482 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.480 | |
| 3ls8 | AJZ | Phosphatidylinositol 3-kinase catalytic subunit type 3 | 2.7.1.137 | 0.479 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.478 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 3ml9 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.477 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.476 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.476 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.476 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.475 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 3akl | ADP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.475 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.474 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.474 | |
| 3ruv | ANP | Chaperonin | / | 0.474 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.474 | |
| 4h6p | FMN | Chromate reductase | / | 0.474 | |
| 4v12 | POG | MaoC like domain protein | / | 0.474 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.473 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.472 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.472 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.471 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1j7l | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.470 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.470 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.469 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 3zcs | CAW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.469 | |
| 2i51 | FMN | Pyridoxamine 5'-phosphate oxidase-related, FMN-binding | / | 0.468 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.468 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.468 | |
| 1g28 | FMN | PHY3 | / | 0.467 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.467 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.467 | |
| 2qtr | NXX | Probable nicotinate-nucleotide adenylyltransferase | / | 0.467 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.467 | |
| 3up0 | D7S | aceDAF-12 | / | 0.467 | |
| 2bkk | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.466 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.466 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.466 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.466 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.465 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.465 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.465 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.465 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.465 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.464 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.464 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4eer | FMN | Phototropin-2 | 2.7.11.1 | 0.463 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.463 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.462 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.462 | |
| 3mx2 | TTP | Nucleoprotein | / | 0.462 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.462 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.462 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.462 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.461 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.461 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.461 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 3b9l | AZZ | Serum albumin | / | 0.460 | |
| 3bbf | GDP | Nucleoside diphosphate kinase B | 2.7.4.6 | 0.460 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.459 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.459 | |
| 1p93 | DEX | Glucocorticoid receptor | / | 0.459 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.459 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 5dn1 | AMZ | Phosphoribosyl isomerase A | 5.3.1.16 | 0.459 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 2b51 | UTP | RNA editing complex protein MP57 | / | 0.458 | |
| 2b56 | UTP | RNA editing complex protein MP57 | / | 0.458 | |
| 2nr4 | FMN | Conserved protein | / | 0.458 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.458 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.458 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 1hqu | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.457 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.457 | |
| 1wc5 | APC | Adenylate cyclase | / | 0.457 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.457 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.457 | |
| 3ahi | HTL | Probable phosphoketolase | / | 0.457 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.457 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.457 | |
| 3zhy | FM6 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.457 | |
| 4ful | 0VU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.456 | |
| 3enk | UPG | UDP-glucose 4-epimerase | / | 0.456 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.456 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.456 | |
| 4e2x | TYD | Methyltransferase | / | 0.456 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.455 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.455 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.455 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.455 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 2nom | DUT | Poly(A) polymerase, putative | / | 0.455 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.455 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.455 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.455 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
| 4k37 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.455 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.455 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 5dp2 | NAP | CurF | / | 0.455 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.454 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.454 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.454 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.454 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.454 | |
| 3ms4 | 21N | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.454 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.454 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.454 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.454 | |
| 4u7w | NDP | MxaA | / | 0.454 | |
| 1yvf | PH7 | Polyprotein | / | 0.453 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.453 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.453 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.453 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4m69 | ANP | Receptor-interacting serine/threonine-protein kinase 3 | 2.7.11.1 | 0.453 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.453 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.452 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.452 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2jlc | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.452 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.452 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.452 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.452 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.452 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.452 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.452 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.451 | |
| 1sui | SAH | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.451 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.451 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.451 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.451 | |
| 2gqw | FAD | Ferredoxin reductase | / | 0.451 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.451 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.451 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.451 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.451 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.451 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.450 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1tys | DHF | Thymidylate synthase | / | 0.450 | |
| 2g1p | SAH | DNA adenine methylase | 2.1.1.72 | 0.450 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.450 | |
| 3a8w | ATP | Protein kinase C iota type | 2.7.11.13 | 0.450 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.450 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.450 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.450 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.450 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.450 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.450 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.450 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.450 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.450 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 1hk4 | T44 | Serum albumin | / | 0.449 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.449 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.449 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.449 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.449 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4fxf | ATP | Pyruvate kinase PKM | 2.7.1.40 | 0.449 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.449 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.449 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.448 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.448 | |
| 2gr0 | FAD | Ferredoxin reductase | / | 0.448 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.448 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.448 | |
| 3lpb | NVB | Tyrosine-protein kinase JAK2 | / | 0.448 | |
| 3mx5 | UTP | Nucleoprotein | / | 0.448 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.448 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.448 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.448 | |
| 4l9q | 9TP | Serum albumin | / | 0.448 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.447 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.447 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.447 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.447 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.447 | |
| 2w4k | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.447 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.447 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.447 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.447 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.447 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.447 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.447 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4j6i | 1JV | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.447 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.446 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 2v0u | FMN | NPH1-1 | / | 0.446 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3g8d | ADP | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.446 | |
| 3rhh | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.446 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.446 | |
| 4u03 | GTP | Cyclic GMP-AMP synthase | / | 0.446 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.446 | |
| 4y0k | NAP | AntE | / | 0.446 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.446 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2db3 | ANP | ATP-dependent RNA helicase vasa, isoform A | 3.6.4.13 | 0.445 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.445 | |
| 2e20 | B4P | Propionate kinase | / | 0.445 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.445 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.445 | |
| 3ori | AGS | Serine/threonine protein kinase | / | 0.445 | |
| 4fa6 | 0TA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.445 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.445 | |
| 1bux | PPS | Nucleoside diphosphate kinase, cytosolic | 2.7.4.6 | 0.444 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.444 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.444 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.444 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.444 | |
| 3akk | ADP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.444 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.444 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.444 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.444 | |
| 4azm | T4B | Fatty acid-binding protein, epidermal | / | 0.444 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.444 | |
| 4nu0 | AP5 | Adenylate kinase | / | 0.444 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.444 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.444 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.443 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.443 | |
| 1r6t | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.443 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.443 | |
| 1wze | NAD | Malate dehydrogenase | / | 0.443 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.443 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.443 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3cvu | FAD | RE11660p | / | 0.443 | |
| 3cy2 | MB9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 3kfm | KAI | Glutamate receptor 4 | / | 0.443 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.443 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.443 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.443 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1osv | CHC | Bile acid receptor | / | 0.442 | |
| 1swt | BTN | Streptavidin | / | 0.442 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.442 | |
| 2ejz | SAH | Diphthine synthase | / | 0.442 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.442 | |
| 2piu | DHT | Androgen receptor | / | 0.442 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.442 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.442 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3i28 | 34N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 3tm0 | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.442 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.442 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.442 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.442 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 4l4x | NDP | AmphI | / | 0.442 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.441 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.441 | |
| 1nen | DNT | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.441 | |
| 1nen | DNT | Succinate dehydrogenase cytochrome b556 subunit | / | 0.441 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2e1z | B4P | Propionate kinase | / | 0.441 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 2pd7 | FAD | Vivid PAS protein VVD | / | 0.441 | |
| 2v1a | FMN | NPH1-1 | / | 0.441 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.441 | |
| 3fr8 | NDP | Ketol-acid reductoisomerase, chloroplastic | 1.1.1.86 | 0.441 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.441 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.441 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.441 | |
| 3uk6 | ADP | RuvB-like 2 | 3.6.4.12 | 0.441 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.441 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4fg8 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.441 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.441 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.441 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.441 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.441 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.440 | |
| 1ke9 | LS5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
| 1oyc | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.440 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 3akl | ANP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.440 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.440 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.440 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.440 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.440 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.440 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4awt | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.440 | |
| 4b1f | KRH | Glutamate racemase | / | 0.440 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.440 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.440 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 |