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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3gxlQIGTGF-beta receptor type-12.7.11.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3gxlQIGTGF-beta receptor type-12.7.11.301.000
3hmm855TGF-beta receptor type-12.7.11.300.730
1vjy460TGF-beta receptor type-12.7.11.300.605
5e8wSTUTGF-beta receptor type-12.7.11.300.595
2wotZZGTGF-beta receptor type-12.7.11.300.548
4dymIYZActivin receptor type-12.7.11.300.529
1u4dDBQActivated CDC42 kinase 1/0.523
1bygSTUTyrosine-protein kinase CSK/0.521
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.515
3mtfA3FActivin receptor type-12.7.11.300.515
5e8ySTUTGF-beta receptor type-22.7.11.300.515
1eh4IC1Casein kinase I homolog 12.7.11.10.513
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.512
1rw8580TGF-beta receptor type-12.7.11.300.510
4gmy0X5Tyrosine-protein kinase JAK2/0.507
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.506
5e8xSTUTGF-beta receptor type-12.7.11.300.504
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.500
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.499
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.498
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.496
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.495
3gubGUBDeath-associated protein kinase 12.7.11.10.495
3l8p0CEAngiopoietin-1 receptor2.7.10.10.495
4aqc88ATyrosine-protein kinase JAK2/0.494
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.493
4c02TAKActivin receptor type-12.7.11.300.491
4e4m0NHTyrosine-protein kinase JAK2/0.491
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.491
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.490
4jqeANPCasein kinase II subunit alpha2.7.11.10.490
1u54ACPActivated CDC42 kinase 1/0.489
3ttjJBIMitogen-activated protein kinase 102.7.11.240.489
4hvi19STyrosine-protein kinase JAK32.7.10.20.489
3ttiKBIMitogen-activated protein kinase 102.7.11.240.487
3zewSTUEphrin type-B receptor 42.7.10.10.487
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.487
4gk3L87Ephrin type-A receptor 32.7.10.10.487
4qmpDKISerine/threonine-protein kinase 242.7.11.10.486
3uyt0CKCasein kinase I isoform delta2.7.11.10.485
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.484
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.484
4jia1K3Tyrosine-protein kinase JAK2/0.484
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.482
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.482
4yuqKS1Calmodulin-like domain protein kinase/0.482
3oom507Activin receptor type-12.7.11.300.481
4ji91M3Tyrosine-protein kinase JAK2/0.481
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.481
3be9P04Casein kinase II subunit alpha2.7.11.10.480
4hnf16WCasein kinase I isoform delta2.7.11.10.480
4anmWULCasein kinase II subunit alpha2.7.11.10.479
4j97ACPFibroblast growth factor receptor 2/0.479
1pmn984Mitogen-activated protein kinase 102.7.11.240.478
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.478
2pvhP19Casein kinase II subunit alpha2.7.11.10.478
2qo9ANPEphrin type-A receptor 32.7.10.10.478
4bgg844Activin receptor type-12.7.11.300.477
5drdATPAurora kinase A2.7.11.10.477
2excJNKMitogen-activated protein kinase 102.7.11.240.476
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.475
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.475
3rak03ZCyclin-dependent kinase 22.7.11.220.475
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.475
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.475
1g5sI17Cyclin-dependent kinase 22.7.11.220.474
3eljGS7Mitogen-activated protein kinase 82.7.11.240.474
3kvxFMYMitogen-activated protein kinase 102.7.11.240.474
2pvnP63Casein kinase II subunit alpha2.7.11.10.473
5dr9SKEAurora kinase A2.7.11.10.473
1xjdSTUProtein kinase C theta type2.7.11.130.472
3i60E86Mitogen-activated protein kinase 12.7.11.240.472
4hvh19RTyrosine-protein kinase JAK32.7.10.20.472
4qmzB49Serine/threonine-protein kinase 242.7.11.10.472
1dawANPCasein kinase II subunit alpha2.7.11.10.471
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.471
3zh8C58Protein kinase C iota type2.7.11.130.471
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.471
2p33J07Mitogen-activated protein kinase 102.7.11.240.470
3iok1P6Tyrosine-protein kinase JAK2/0.470
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.470
4iwd1JCHepatocyte growth factor receptor2.7.10.10.470
4ux9ANPMitogen-activated protein kinase 82.7.11.240.470
1aq1STUCyclin-dependent kinase 22.7.11.220.469
4hge15VTyrosine-protein kinase JAK2/0.469
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.468
4fko20KCyclin-dependent kinase 22.7.11.220.468
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.468
1h1s4SPCyclin-dependent kinase 22.7.11.220.467
1yvj4STTyrosine-protein kinase JAK32.7.10.20.467
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.467
3rmf20ZCyclin-dependent kinase 22.7.11.220.467
4lfiGNPCasein kinase II subunit alpha2.7.11.10.467
5cnoANPEpidermal growth factor receptor2.7.10.10.467
5dr6SKEAurora kinase A2.7.11.10.467
1y91CT9Cyclin-dependent kinase 22.7.11.220.466
2x1nX1NCyclin-dependent kinase 22.7.11.220.466
2xa4AZ5Tyrosine-protein kinase JAK2/0.466
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.466
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.466
4eor4SPCyclin-dependent kinase 22.7.11.220.466
4fkr45KCyclin-dependent kinase 22.7.11.220.466
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4kbk1QGCasein kinase I isoform delta2.7.11.10.466
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.466
3s1h56ZCyclin-dependent kinase 22.7.11.220.465
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.465
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.465
4c61LMMTyrosine-protein kinase JAK2/0.465
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.465
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.465
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.465
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.464
2w06FRVCyclin-dependent kinase 22.7.11.220.464
2in6839Wee1-like protein kinase2.7.10.20.463
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.463
4fkv61KCyclin-dependent kinase 22.7.11.220.463
2b53D23Cyclin-dependent kinase 22.7.11.220.462
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.462
4riyADPEpidermal growth factor receptor2.7.10.10.461
1oirHDYCyclin-dependent kinase 22.7.11.220.460
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.460
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.460
4f081RSTyrosine-protein kinase JAK2/0.460
1py5PY1TGF-beta receptor type-12.7.11.300.459
2o0uC0MMitogen-activated protein kinase 102.7.11.240.459
3sheI85MAP kinase-activated protein kinase 32.7.11.10.459
4gk2L66Ephrin type-A receptor 32.7.10.10.459
4k33ACPFibroblast growth factor receptor 32.7.10.10.459
5cnnANPEpidermal growth factor receptor2.7.10.10.459
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.459
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.458
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.458
2zdt46CMitogen-activated protein kinase 102.7.11.240.458
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.458
3ddqRRCCyclin-dependent kinase 22.7.11.220.458
3rkb12ZCyclin-dependent kinase 22.7.11.220.458
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.458
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.458
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.458
4ewhT77Activated CDC42 kinase 1/0.458
4gk4L90Ephrin type-A receptor 32.7.10.10.458
4j95ACPFibroblast growth factor receptor 2/0.458
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.458
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.458
5e92ANPTGF-beta receptor type-22.7.11.300.458
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.457
2hk51BMTyrosine-protein kinase HCK2.7.10.20.457
3vs3VSETyrosine-protein kinase HCK2.7.10.20.457
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.457
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.457
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.457
1oguST8Cyclin-dependent kinase 22.7.11.220.456
3lpbNVBTyrosine-protein kinase JAK2/0.456
3qtxX43Cyclin-dependent kinase 22.7.11.220.456
3vryB43Tyrosine-protein kinase HCK2.7.10.20.456
4qmlANPSerine/threonine-protein kinase 242.7.11.10.456
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1xkkFMMEpidermal growth factor receptor2.7.10.10.455
2eufLQQCyclin-dependent kinase 62.7.11.220.455
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.455
3k5uPFQAurora kinase A2.7.11.10.455
3r83Z14Cyclin-dependent kinase 22.7.11.220.455
3w33W19Epidermal growth factor receptor2.7.10.10.455
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.455
4jq8KJ8Epidermal growth factor receptor2.7.10.10.455
1e3eNAIAlcohol dehydrogenase 41.1.1.10.454
1m2pHNACasein kinase II subunit alpha2.7.11.10.454
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.454
2iw84SPCyclin-dependent kinase 22.7.11.220.454
4btjATPTau-tubulin kinase 12.7.11.10.454
4qnyANPMitogen activated protein kinase, putative/0.454
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.453
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.453
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2dwbANPAurora kinase A2.7.11.10.453
2yn8STUEphrin type-B receptor 42.7.10.10.453
3zep1NXTyrosine-protein kinase JAK32.7.10.20.453
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.453
2izrBRKCasein kinase I isoform gamma-32.7.11.10.452
2wouZZFTGF-beta receptor type-12.7.11.300.452
3ddpRC8Cyclin-dependent kinase 22.7.11.220.452
3rk708ZCyclin-dependent kinase 22.7.11.220.452
3sw418KCyclin-dependent kinase 22.7.11.220.452
3tqhNDPQuinone oxidoreductase/0.452
3uzp0CKCasein kinase I isoform delta2.7.11.10.452
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
4fv7E94Mitogen-activated protein kinase 12.7.11.240.452
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.452
4lopSB4Mitogen-activated protein kinase 14/0.452
4y93746Tyrosine-protein kinase/0.452
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.452
2b1pAIZMitogen-activated protein kinase 102.7.11.240.451
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.451
3a7jADPSerine/threonine-protein kinase 242.7.11.10.451
3at4CCKCasein kinase II subunit alpha2.7.11.10.451
3gc9B45Mitogen-activated protein kinase 112.7.11.240.451
3qu0X40Cyclin-dependent kinase 22.7.11.220.451
4hgt15GCasein kinase I isoform delta2.7.11.10.451
1gih1PUCyclin-dependent kinase 22.7.11.220.450
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.450
3a60STURibosomal protein S6 kinase beta-12.7.11.10.450
3lfqA28Cyclin-dependent kinase 22.7.11.220.450
4acm7YGCyclin-dependent kinase 22.7.11.220.450
4btjADPTau-tubulin kinase 12.7.11.10.450
4nk92K5Fibroblast growth factor receptor 1/0.450
1di8DTQCyclin-dependent kinase 22.7.11.220.449
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.449
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.449
3le62BZCyclin-dependent kinase 22.7.11.220.449
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.449
4g2fC07Ephrin type-A receptor 32.7.10.10.449
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
4jr3KJREpidermal growth factor receptor2.7.10.10.449
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.449
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.449
2xngA0HAurora kinase A2.7.11.10.448
3nxe2NCProtease/0.448
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.448
3r9oZ71Cyclin-dependent kinase 22.7.11.220.448
3zpsEQMGag-Pol polyprotein3.4.23.160.448
4fob0USALK tyrosine kinase receptor2.7.10.10.448
4i22IREEpidermal growth factor receptor2.7.10.10.448
1gii1PUCyclin-dependent kinase 22.7.11.220.447
1ol7ADPAurora kinase A2.7.11.10.447
2pvlP55Casein kinase II subunit alpha2.7.11.10.447
2uzbC75Cyclin-dependent kinase 22.7.11.220.447
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2vv9IM9Cyclin-dependent kinase 22.7.11.220.447
2w17I19Cyclin-dependent kinase 22.7.11.220.447
2x9fX9FEphrin type-B receptor 42.7.10.10.447
2xnbY8LCyclin-dependent kinase 22.7.11.220.447
2xyuQ9GEphrin type-A receptor 42.7.10.10.447
2y6o1N1Ephrin type-A receptor 42.7.10.10.447
3hx4ANPCalmodulin-domain protein kinase 1/0.447
3ormAGSSerine/threonine protein kinase/0.447
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.447
3vt9YI4Vitamin D3 receptor/0.447
3zptM8YGag-Pol polyprotein3.4.23.160.447
4fkw62KCyclin-dependent kinase 22.7.11.220.447
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.447
1bsvNDPGDP-L-fucose synthase/0.446
2b52D42Cyclin-dependent kinase 22.7.11.220.446
2bhhRYUCyclin-dependent kinase 22.7.11.220.446
2h96893Mitogen-activated protein kinase 82.7.11.240.446
3lfnA27Cyclin-dependent kinase 22.7.11.220.446
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.446
4c4jX21Dual specificity protein kinase TTK2.7.12.10.446
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4ez50RSCyclin-dependent kinase 62.7.11.220.446
4g1wG1WMitogen-activated protein kinase 82.7.11.240.446
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.446
4iva1J5Tyrosine-protein kinase JAK2/0.446
4y95746Tyrosine-protein kinase/0.446
1jnkANPMitogen-activated protein kinase 102.7.11.240.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1oitHDTCyclin-dependent kinase 22.7.11.220.445
1oiuN76Cyclin-dependent kinase 22.7.11.220.445
1om1IQACasein kinase II subunit alpha2.7.11.10.445
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.445
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
3at3ATKCasein kinase II subunit alpha2.7.11.10.445
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
3oriAGSSerine/threonine protein kinase/0.445
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
3rvg17PTyrosine-protein kinase JAK2/0.445
3vt8YI3Vitamin D3 receptor/0.445
4dgnLU2Casein kinase II subunit alpha2.7.11.10.445
5dt3ATPAurora kinase A2.7.11.10.445
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.444
2pwlACPFibroblast growth factor receptor 2/0.444
2wihP48Cyclin-dependent kinase 22.7.11.220.444
3cr0809Wee1-like protein kinase2.7.10.20.444
3cukFADD-amino-acid oxidase1.4.3.30.444
3dogNNNCyclin-dependent kinase 22.7.11.220.444
3qtzX42Cyclin-dependent kinase 22.7.11.220.444
4gub0Y4Casein kinase II subunit alpha2.7.11.10.444
4id71G0Activated CDC42 kinase 1/0.444
4qmySTUSerine/threonine-protein kinase 242.7.11.10.444
4uymVOR14-alpha sterol demethylase Cyp51B/0.444
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.443
1w8cN69Cyclin-dependent kinase 22.7.11.220.443
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.443
2b7aIZATyrosine-protein kinase JAK2/0.443
2iw94SPCyclin-dependent kinase 22.7.11.220.443
2vttLZDCyclin-dependent kinase 22.7.11.220.443
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.443
3pqbVGPPutative oxidoreductase/0.443
3t3c017Gag-Pol polyprotein3.4.23.160.443
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.442
2c6lDT4Cyclin-dependent kinase 22.7.11.220.442
2cchATPCyclin-dependent kinase 22.7.11.220.442
3rni21ZCyclin-dependent kinase 22.7.11.220.442
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.442
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.441
2c6o4SPCyclin-dependent kinase 22.7.11.220.441
2itnANPEpidermal growth factor receptor2.7.10.10.441
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.441
2vwz7X6Ephrin type-B receptor 42.7.10.10.441
2w05FRTCyclin-dependent kinase 22.7.11.220.441
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.441
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.441
1ke7LS3Cyclin-dependent kinase 22.7.11.220.440
1ol5ADPAurora kinase A2.7.11.10.440
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.440
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.440
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.440
3r71X86Cyclin-dependent kinase 22.7.11.220.440
3sqq99ZCyclin-dependent kinase 22.7.11.220.440
3t8oATPRhodopsin kinase/0.440
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.440
4erwSTUCyclin-dependent kinase 22.7.11.220.440
4hvg19QTyrosine-protein kinase JAK32.7.10.20.440
4jr7GNPCasein kinase II subunit alpha2.7.11.10.440
4wkqIREEpidermal growth factor receptor2.7.10.10.440