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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3grsFADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3grsFADGlutathione reductase, mitochondrial1.8.1.71.000
1grhFADGlutathione reductase, mitochondrial1.8.1.70.884
1grgFADGlutathione reductase, mitochondrial1.8.1.70.871
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.853
1graFADGlutathione reductase, mitochondrial1.8.1.70.851
1greFADGlutathione reductase, mitochondrial1.8.1.70.844
1grbFADGlutathione reductase, mitochondrial1.8.1.70.704
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.656
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.626
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.622
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.602
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.601
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.588
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.563
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.546
2v6oFADThioredoxin glutathione reductase/0.534
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.530
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.484
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.483
2r9zFADGlutathione amide reductase/0.483
2rabFADGlutathione amide reductase/0.464
1gerFADGlutathione reductase1.8.1.70.463
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.463
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.456
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.455
3djgFADGlutathione reductase, mitochondrial1.8.1.70.453
1febFADTrypanothione reductase1.8.1.120.440