scPDB - Distribution of Binding site Similarity values of 3gi2 entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3gi2	GHW	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	1.000
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.645
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.645
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.641
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.625
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.607
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.602
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.601
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.600
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.597
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.578
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.566
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.561
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.560
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.557
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.538
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.536
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.535
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.529
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.524
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.524
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.524
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.519
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.517
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.515
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.506
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.501
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.497
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.494
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.491
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.487
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.486
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.482
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.479
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.477
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.473
1q0r	AKT	Aclacinomycin methylesterase RdmC	3.1.1.95	0.470
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.470
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.461
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.456
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.455
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.454
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.449
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.448
1thz	326	Bifunctional purine biosynthesis protein PURH	2.1.2.3	0.446
1uho	VDN	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.444
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.444
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.442
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.441
3qly	55V	Uncharacterized protein	/	0.441