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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ghuLDTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ghuLDTAldose reductase1.1.1.211.000
3ghtLDTAldose reductase1.1.1.210.829
3ghsLDTAldose reductase1.1.1.210.815
2i17LDTAldose reductase1.1.1.210.813
1us0LDTAldose reductase1.1.1.210.806
2qxwLDTAldose reductase1.1.1.210.805
3g5eQ74Aldose reductase1.1.1.210.783
3ghrLDTAldose reductase1.1.1.210.755
2i16LDTAldose reductase1.1.1.210.749
1z3n3NAAldose reductase1.1.1.210.727
2hvoZSTAldose reductase1.1.1.210.721
2hv5ZSTAldose reductase1.1.1.210.702
2pdiZSTAldose reductase1.1.1.210.693
3ld5LDTAldose reductase1.1.1.210.693
1pwlBFIAldose reductase1.1.1.210.689
2pdxZSTAldose reductase1.1.1.210.689
2duxZSTAldose reductase1.1.1.210.687
2fz8ZSTAldose reductase1.1.1.210.679
2hvnZSTAldose reductase1.1.1.210.666
3mb9ZSTAldose reductase1.1.1.210.661
2pzn393Aldose reductase1.1.1.210.651
2duzZSTAldose reductase1.1.1.210.649
1t40ID5Aldose reductase1.1.1.210.639
2dv0ZSTAldose reductase1.1.1.210.625
2pdh47DAldose reductase1.1.1.210.625
3lz5LDTAldose reductase1.1.1.210.624
2pdmZSTAldose reductase1.1.1.210.622
2pdu393Aldose reductase1.1.1.210.620
3mc5393Aldose reductase1.1.1.210.617
2pdp393Aldose reductase1.1.1.210.615
2pdfZSTAldose reductase1.1.1.210.614
3m0iZSTAldose reductase1.1.1.210.610
2pdg47DAldose reductase1.1.1.210.605
4yu153NAldose reductase1.1.1.210.604
2pdbZSTAldose reductase1.1.1.210.599
2pdlTOLAldose reductase1.1.1.210.599
3t423T4Aldose reductase1.1.1.210.599
4gca2X9Aldose reductase1.1.1.210.599
3lqlLDTAldose reductase1.1.1.210.597
3m64393Aldose reductase1.1.1.210.597
1z8962PAldose reductase1.1.1.210.596
3lenZSTAldose reductase1.1.1.210.592
2pdn47DAldose reductase1.1.1.210.590
3lboLDTAldose reductase1.1.1.210.590
2pd5ZSTAldose reductase1.1.1.210.589
2pdc393Aldose reductase1.1.1.210.589
3m4h388Aldose reductase1.1.1.210.587
2pdj393Aldose reductase1.1.1.210.582
1frbZSTAldose reductase-related protein 2/0.581
2fz9ZSTAldose reductase1.1.1.210.580
1t41ID5Aldose reductase1.1.1.210.578
2fzdTOLAldose reductase1.1.1.210.578
2iki388Aldose reductase1.1.1.210.576
2pdq47DAldose reductase1.1.1.210.575
1ieiZESAldose reductase1.1.1.210.567
2ikhLITAldose reductase1.1.1.210.563
1zuaTOLAldo-keto reductase family 1 member B101.1.10.560
1ah3TOLAldose reductase1.1.1.210.522
2pdyFIDAldose reductase1.1.1.210.516
2ikj393Aldose reductase1.1.1.210.505
1ekoI84Aldose reductase1.1.1.210.498
2is72CLAldose reductase1.1.1.210.497
1el3I84Aldose reductase1.1.1.210.491
2agtFIDAldose reductase1.1.1.210.491
2f2kTGGAldose reductase1.1.1.210.490
2pdwFIDAldose reductase1.1.1.210.489
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.488
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.481
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.477
2fzbTOLAldose reductase1.1.1.210.476
2nvcITAAldose reductase1.1.1.210.476
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
5liu388Aldo-keto reductase family 1 member B101.1.10.476
2iqdLPAAldose reductase1.1.1.210.475
4e0u0MVCyclic dipeptide N-prenyltransferase/0.475
4lrhFOLFolate receptor alpha/0.475
4u163C0Muscarinic acetylcholine receptor M3/0.475
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.472
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.472
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.471
3v35NTIAldose reductase1.1.1.210.470
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.469
3r8hZOMAldo-keto reductase family 1 member C3/0.468
3uonQNBMuscarinic acetylcholine receptor M2/0.468
1x8lOXRRetinol dehydratase/0.467
2pdkSBIAldose reductase1.1.1.210.467
2aovC2MHistamine N-methyltransferase2.1.1.80.466
3u2cSUZAldose reductase1.1.1.210.466
2inzOHPAldose reductase1.1.1.210.465
2xupTZ5Acetylcholinesterase3.1.1.70.465
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.465
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.464
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.462
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.462
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.462
3gf4UPGUDP-galactopyranose mutase5.4.99.90.461
2cbqTH2Neocarzinostatin/0.460
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.460
2vbpVB1Isopenicillin N synthase1.21.3.10.460
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.460
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.460
5d5aCAUBeta-2 adrenergic receptor/0.460
1s36CEIObelin/0.459
2bjsACVIsopenicillin N synthase1.21.3.10.459
2cekN8TAcetylcholinesterase3.1.1.70.459
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.459
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.459
3s3gTLTAldose reductase1.1.1.210.459
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.459
4dbw511Aldo-keto reductase family 1 member C3/0.459
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.458
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
2bfmTOPPteridine reductase 11.5.1.330.458
3uweVJJAldo-keto reductase family 1 member C3/0.458
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.458
1odcA8BAcetylcholinesterase3.1.1.70.457
1q23FUAChloramphenicol acetyltransferase2.3.1.280.457
1s9dAFBCytohesin-2/0.457
1s9dAFBADP-ribosylation factor 1/0.457
2ga2A19Methionine aminopeptidase 2/0.457
3f3y4OABile salt sulfotransferase2.8.2.140.457
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.457
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
1zgbA1EAcetylcholinesterase3.1.1.70.456
4bftZVTPantothenate kinase2.7.1.330.456
4hmn16JAldo-keto reductase family 1 member C3/0.456
4i5xFLFAldo-keto reductase family 1 member B101.1.10.456
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.456
4paaTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.456
4wevSUZAldo-keto reductase family 1 member B101.1.10.456
1ah0SBIAldose reductase1.1.1.210.455
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
1s2cFLFAldo-keto reductase family 1 member C3/0.455
2aouCQAHistamine N-methyltransferase2.1.1.80.455
2ea4F79Methionine aminopeptidase 2/0.455
3inrGDUUDP-galactopyranose mutase5.4.99.90.455
4kmzFOLFolate receptor beta/0.455
4kn2LYAFolate receptor beta/0.455
1lnmDTXBilin-binding protein/0.454
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2f3815MAldo-keto reductase family 1 member C3/0.454
3h3r14HCollagen type IV alpha-3-binding protein/0.454
4hcy0YNTransketolase/0.454
4u140HKMuscarinic acetylcholine receptor M3/0.454
1dghNDPCatalase1.11.1.60.453
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.453
4xwtU5PRibonuclease J/0.453
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.452
4bjbP34Tankyrase-22.4.2.300.452
4li61XOTankyrase-12.4.2.300.452
4nwiCTN7-methylguanosine phosphate-specific 5'-nucleotidase/0.452
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.451
4jt91NSNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.451
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.451
2aot2PMHistamine N-methyltransferase2.1.1.80.450
3rsv3RSBeta-secretase 13.4.23.460.450
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.450
4bj9UHBTankyrase-22.4.2.300.450
4cdmFO1Deoxyribodipyrimidine photolyase/0.450
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
5stdUNNScytalone dehydratase4.2.1.940.450
1ry0PG2Aldo-keto reductase family 1 member C3/0.449
2xujTZ5Acetylcholinesterase3.1.1.70.449
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.448
2w6cBM4Acetylcholinesterase3.1.1.70.448
2wo7ASVIsopenicillin N synthase1.21.3.10.448
3iu9T07Methionine aminopeptidase 2/0.448
3n0hTOPDihydrofolate reductase1.5.1.30.448
4ey7E20Acetylcholinesterase3.1.1.70.448
5c1gGDUHisto-blood group ABO system transferase/0.448
1eveE20Acetylcholinesterase3.1.1.70.447
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
1ihiIU5Aldo-keto reductase family 1 member C2/0.446
1kwcBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.446
1pj6FOLDimethylglycine oxidase1.5.3.100.446
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1qv0CZHObelin/0.446
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.446
2zs9ADPPantothenate kinase2.7.1.330.446
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.446
4fam0SZAldo-keto reductase family 1 member C3/0.446
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.445
1oc1ASVIsopenicillin N synthase1.21.3.10.445
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1yw9A84Methionine aminopeptidase 2/0.445
4kn0MTXFolate receptor beta/0.445
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.444
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.444
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
2rds1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.444
2xufTZ4Acetylcholinesterase3.1.1.70.444
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.444
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.444
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.443
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.443
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.443
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.443
4b65NDPL-ornithine N(5)-monooxygenase/0.443
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.443
4lcnGNGCytidine and deoxycytidylate deaminase zinc-binding region/0.443
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.443
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1touB1VFatty acid-binding protein, adipocyte/0.442
1yw7A41Methionine aminopeptidase 2/0.442
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3r43ID8Aldo-keto reductase family 1 member C3/0.442
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.442
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.442
4pnmNU1Tankyrase-22.4.2.300.442
4q7f3D1Uncharacterized protein/0.442
4xo7ASDAldo-keto reductase family 1 member C2/0.442
2yczI32Beta-1 adrenergic receptor/0.442
1r58AO5Methionine aminopeptidase 2/0.441
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
2vt4P32Beta-1 adrenergic receptor/0.441
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3pn1IVHDNA ligase/0.441
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.441
3ug8IMNAldo-keto reductase family 1 member C3/0.441
4ea2RWZDehydrosqualene synthase/0.441
4kn104JFolate receptor beta/0.441
1c7oPPGHemolysin/0.440
2ckmAA7Acetylcholinesterase3.1.1.70.440
2wu4HBPAcetylcholinesterase3.1.1.70.440
2y6fM9FIsopenicillin N synthase1.21.3.10.440
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.440
4bfxZVXPantothenate kinase2.7.1.330.440