sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3gfx | C2E | Uncharacterized protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3gfx | C2E | Uncharacterized protein | / | 1.000 | |
| 3gg1 | C2E | Uncharacterized protein | / | 0.571 | |
| 3gg0 | C2E | Uncharacterized protein | / | 0.550 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.524 | |
| 3gfz | C2E | Uncharacterized protein | / | 0.520 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.511 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.508 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.503 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.501 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 4ds8 | A8S | Abscisic acid receptor PYL3 | / | 0.498 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.496 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.496 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.493 | |
| 4nj3 | 2KD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.492 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3uud | EST | Estrogen receptor | / | 0.488 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.488 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.487 | |
| 1nd5 | 2BF | Prostatic acid phosphatase | 3.1.3.2 | 0.486 | |
| 3lq2 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.485 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.485 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.483 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.482 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.482 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.481 | |
| 3jrx | S1A | Acetyl-CoA carboxylase 2 | / | 0.480 | |
| 3k90 | A8S | Abscisic acid receptor PYR1 | / | 0.480 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.480 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.480 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.480 | |
| 3r8z | Z63 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.478 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.478 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.478 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.477 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.476 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.476 | |
| 3ely | SAH | Methyltransferase | / | 0.474 | |
| 3upt | TPP | Transketolase | / | 0.474 | |
| 2zce | PYL | Pyrrolysine--tRNA ligase | / | 0.473 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.473 | |
| 1x7e | 244 | Estrogen receptor | / | 0.472 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 3kdj | A8S | Abscisic acid receptor PYL1 | / | 0.472 | |
| 4v12 | POG | MaoC like domain protein | / | 0.472 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.471 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.471 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.470 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.470 | |
| 3qly | 55V | Uncharacterized protein | / | 0.470 | |
| 3roe | THM | NAD(P)H-hydrate epimerase | 5.1.99.6 | 0.470 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.469 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.469 | |
| 2yja | EST | Estrogen receptor | / | 0.469 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 2g44 | T3O | Estrogen receptor | / | 0.468 | |
| 2xau | ADP | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 | 3.6.4.13 | 0.468 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.467 | |
| 1wc1 | TAT | Adenylate cyclase | / | 0.467 | |
| 1wpg | ADP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.467 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.467 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 2px2 | SAH | Genome polyprotein | 2.7.7.48 | 0.467 | |
| 3cse | N22 | Uncharacterized protein | / | 0.467 | |
| 3ols | EST | Estrogen receptor beta | / | 0.467 | |
| 3zbx | 6XE | Hepatocyte growth factor receptor | 2.7.10.1 | 0.467 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.466 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.466 | |
| 4p6x | HCY | Glucocorticoid receptor | / | 0.466 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.465 | |
| 2wms | ZYS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 1syn | F89 | Thymidylate synthase | / | 0.464 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.464 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.464 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.464 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.464 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.463 | |
| 2bhe | BRY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 2fai | 459 | Estrogen receptor | / | 0.463 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.463 | |
| 3ag9 | A02 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.463 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.463 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1v0o | INR | Cell division control protein 2 homolog | 2.7.11.22 | 0.462 | |
| 2j5s | KTA | Alr4455 protein | / | 0.462 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.462 | |
| 1d7o | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.461 | |
| 1gwr | EST | Estrogen receptor | / | 0.461 | |
| 2b51 | UTP | RNA editing complex protein MP57 | / | 0.461 | |
| 3a8w | ATP | Protein kinase C iota type | 2.7.11.13 | 0.461 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.461 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 2qkr | IXM | Cdc2-like CDK2/CDC28 like protein kinase | / | 0.460 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 2xjg | XJG | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 4xz3 | COA | Acyl-CoA synthetase (NDP forming) | / | 0.460 | |
| 1u3s | 797 | Estrogen receptor beta | / | 0.459 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.459 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.459 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.459 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.459 | |
| 5fsx | ADP | Uncharacterized protein | / | 0.459 | |
| 4eol | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 5htp | ANP | Probable sugar kinase | / | 0.458 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.457 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.457 | |
| 3tnw | F18 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 4eqc | XR1 | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.456 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.455 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 1wc3 | APC | Adenylate cyclase | / | 0.455 | |
| 1wc5 | APC | Adenylate cyclase | / | 0.455 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.455 | |
| 3l03 | 4OH | Estrogen receptor | / | 0.455 | |
| 3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.455 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.455 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.455 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.455 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.455 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.455 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 2b1z | 17M | Estrogen receptor | / | 0.454 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 3eem | 53V | Uncharacterized protein | / | 0.454 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.454 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.454 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4eip | K2C | Putative FAD-monooxygenase | / | 0.454 | |
| 4fki | 09K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.454 | |
| 4oic | A8S | Bet v I allergen-like | / | 0.454 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1rg9 | SAM | S-adenosylmethionine synthase | 2.5.1.6 | 0.453 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.453 | |
| 2kfx | WW7 | Troponin C, slow skeletal and cardiac muscles | / | 0.453 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3oll | EST | Estrogen receptor beta | / | 0.453 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.453 | |
| 4b5p | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.453 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.452 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.452 | |
| 1xha | R68 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.452 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 2b35 | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2f7e | 2EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.452 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.452 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 2bxo | OPB | Serum albumin | / | 0.451 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.451 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.451 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.451 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4igf | CHV | Enoyl-acyl carrier reductase | / | 0.451 | |
| 4ndn | SAM | S-adenosylmethionine synthase isoform type-2 | 2.5.1.6 | 0.451 | |
| 4pp6 | STL | Estrogen receptor | / | 0.451 | |
| 4u0o | MTA | Lipoyl synthase 2 | / | 0.451 | |
| 1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.450 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.450 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2aa7 | 1CA | Mineralocorticoid receptor | / | 0.450 | |
| 2op0 | 7PC | Enoyl-ACP reductase | / | 0.450 | |
| 2vn9 | GVD | Calcium/calmodulin-dependent protein kinase type II subunit delta | 2.7.11.17 | 0.450 | |
| 2zi6 | 3D1 | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.450 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.450 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.450 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.450 | |
| 4kfb | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.450 | |
| 1hk4 | T44 | Serum albumin | / | 0.449 | |
| 1kdk | DHT | Sex hormone-binding globulin | / | 0.449 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2nv7 | 555 | Estrogen receptor beta | / | 0.449 | |
| 2uw6 | GVO | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.449 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.449 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.449 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1nv9 | SAH | Release factor glutamine methyltransferase | 2.1.1.297 | 0.448 | |
| 1zky | 689 | Estrogen receptor | / | 0.448 | |
| 2ieh | MOY | Kinesin-like protein KIF11 | / | 0.448 | |
| 2o21 | 43B | Apoptosis regulator Bcl-2 | / | 0.448 | |
| 2olc | ADP | Methylthioribose kinase | 2.7.1.100 | 0.448 | |
| 2w8y | NDR | Progesterone receptor | / | 0.448 | |
| 2yx6 | ADP | Uncharacterized protein | / | 0.448 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.448 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.448 | |
| 3nfr | EWQ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.448 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.448 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.448 | |
| 4hjf | C2E | GGDEF family protein | / | 0.448 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.448 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.447 | |
| 1g50 | EST | Estrogen receptor | / | 0.447 | |
| 1psd | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.447 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.447 | |
| 1u3g | THF | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.447 | |
| 2ab2 | SNL | Mineralocorticoid receptor | / | 0.447 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 3qn1 | A8S | Abscisic acid receptor PYR1 | / | 0.447 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.447 | |
| 4app | N53 | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.447 | |
| 4axa | RKD | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 4ple | CPS | Nuclear receptor subfamily 5 group A member 2 | / | 0.447 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.447 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1lce | TMF | Thymidylate synthase | / | 0.446 | |
| 1q66 | KMB | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.446 | |
| 1wc4 | APC | Adenylate cyclase | / | 0.446 | |
| 1z2n | ADP | Inositol-tetrakisphosphate 1-kinase | 2.7.1.134 | 0.446 | |
| 2x7c | KZ9 | Kinesin-like protein KIF11 | / | 0.446 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 5dxg | EST | Estrogen receptor | / | 0.446 | |
| 5hyr | EST | Estrogen receptor | / | 0.446 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.445 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1q65 | BHB | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 1v93 | FAD | Methylenetetrahydrofolate reductase | / | 0.445 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.445 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2p3q | SAH | Genome polyprotein | / | 0.445 | |
| 2r5n | TPP | Transketolase 1 | / | 0.445 | |
| 2v95 | HCY | Corticosteroid-binding globulin | / | 0.445 | |
| 2zwv | SAH | Probable ribosomal RNA small subunit methyltransferase | / | 0.445 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 4fhy | 3AT | Terminal uridylyltransferase cid1 | / | 0.445 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.445 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.445 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1fgi | SU1 | Fibroblast growth factor receptor 1 | / | 0.444 | |
| 1hnv | TBO | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1ikw | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2pkl | DHT | Androgen receptor | / | 0.444 | |
| 3erd | DES | Estrogen receptor | / | 0.444 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.444 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.444 | |
| 3zo4 | QWI | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 4bec | ATP | Type I restriction enzyme EcoR124II R protein | 3.1.21.3 | 0.444 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.444 | |
| 4wzy | ATP | Maltokinase | 2.7.1.175 | 0.444 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.444 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.443 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1l2i | ETC | Estrogen receptor | / | 0.443 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1nv8 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.443 | |
| 1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.443 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1wc0 | APC | Adenylate cyclase | / | 0.443 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.443 | |
| 2ggq | TTP | Dual sugar-1-phosphate nucleotidylyltransferase | / | 0.443 | |
| 2gu8 | 796 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.443 | |
| 2ji6 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.443 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.443 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2yhd | TES | Androgen receptor | / | 0.443 | |
| 2ym3 | YM3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3lcd | BDY | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.443 | |
| 3ngu | ADP | Nucleoside diphosphate kinase | / | 0.443 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.443 | |
| 3rm7 | 19Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3s2p | PMU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3zra | ORB | Progesterone receptor | / | 0.443 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4eix | NIM | Phospholipase A2 VRV-PL-VIIIa | / | 0.443 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.442 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1w78 | PD8 | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.442 | |
| 1xpc | AIT | Estrogen receptor | / | 0.442 | |
| 1yy4 | 4NA | Estrogen receptor beta | / | 0.442 | |
| 2ao6 | R18 | Androgen receptor | / | 0.442 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2vwv | 7X3 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.442 | |
| 2wpw | ACO | Orf14 | / | 0.442 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.442 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.442 | |
| 4fa6 | 0TA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4l64 | C2F | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | 2.1.1.14 | 0.442 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.442 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 1gy3 | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1hk5 | T44 | Serum albumin | / | 0.441 | |
| 1l9k | SAH | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.441 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.441 | |
| 1ne4 | RP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.441 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2bxf | DZP | Serum albumin | / | 0.441 | |
| 2c1a | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2gnf | Y27 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.441 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.441 | |
| 3anm | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.441 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4a51 | DQ8 | Kinesin-like protein KIF11 | / | 0.441 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 4dlx | GNP | GTPase HRas | / | 0.441 | |
| 4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4gg9 | 0WW | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.441 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1dm2 | HMD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 1wbp | ADP | SRSF protein kinase 1 | 2.7.11.1 | 0.440 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1yim | CM4 | Estrogen receptor | / | 0.440 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.440 | |
| 2oal | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.440 | |
| 2ouz | C3D | Estrogen receptor | / | 0.440 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.440 | |
| 2v1a | FMN | NPH1-1 | / | 0.440 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 3a7d | FBN | Catechol O-methyltransferase | 2.1.1.6 | 0.440 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.440 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3zxs | FAD | Deoxyribodipyrimidine photolyase-related protein | / | 0.440 | |
| 4eer | FMN | Phototropin-2 | 2.7.11.1 | 0.440 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4man | 1Y1 | Apoptosis regulator Bcl-2 | / | 0.440 | |
| 4ogr | ADN | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.440 | |
| 4qmu | SKE | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 |