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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3gcvSS6Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3gcvSS6Mitogen-activated protein kinase 14/1.000
3gcuR48Mitogen-activated protein kinase 14/0.582
3hv4L51Mitogen-activated protein kinase 14/0.550
2yisYISMitogen-activated protein kinase 14/0.531
3uvr06FMitogen-activated protein kinase 14/0.512
3hv6R39Mitogen-activated protein kinase 14/0.509
1kv2B96Mitogen-activated protein kinase 14/0.505
3p7cP7CMitogen-activated protein kinase 14/0.504
3p7bP7BMitogen-activated protein kinase 14/0.500
3lfbZ87Mitogen-activated protein kinase 14/0.494
3hv71AUMitogen-activated protein kinase 14/0.490
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.489
1w82L10Mitogen-activated protein kinase 14/0.486
3gi3B10Mitogen-activated protein kinase 14/0.485
3p7aP7AMitogen-activated protein kinase 14/0.480
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.479
4qjqOTRLactoperoxidase/0.477
2puuG2GMitogen-activated protein kinase 14/0.476
3nnwEDDMitogen-activated protein kinase 14/0.476
3o8uBMUMitogen-activated protein kinase 14/0.475
1wbtWBTMitogen-activated protein kinase 14/0.473
1wbsLI2Mitogen-activated protein kinase 14/0.470
3p5kP5KMitogen-activated protein kinase 14/0.467
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.464
2yiwYIWMitogen-activated protein kinase 14/0.463
3lffZ83Mitogen-activated protein kinase 14/0.463
4eh90OQMitogen-activated protein kinase 14/0.463
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.462
3k3jF4CMitogen-activated protein kinase 14/0.459
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.458
4n6hEJ4Delta-type opioid receptor/0.458
1wbnL09Mitogen-activated protein kinase 14/0.456
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.455
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.454
3p79P79Mitogen-activated protein kinase 14/0.454
1kv1BMUMitogen-activated protein kinase 14/0.453
3uwqU5POrotidine 5'-phosphate decarboxylase/0.453
3e9319BMitogen-activated protein kinase 14/0.452
5ifyTRHGlucose-1-phosphate thymidylyltransferase/0.452
2jn3JN3Fatty acid-binding protein, liver/0.451
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.450
4jx1CAMCamphor 5-monooxygenase1.14.15.10.450
1wbvLI3Mitogen-activated protein kinase 14/0.449
3fnlSHALactoperoxidase/0.449
3isjA8DPantothenate synthetase6.3.2.10.449
3uk6ADPRuvB-like 23.6.4.120.449
3nnxEDDMitogen-activated protein kinase 14/0.448
1d7yFADFerredoxin reductase/0.447
1re9DSOCamphor 5-monooxygenase1.14.15.10.447
2rc3NADCBS domain/0.447
1k6pXN3Gag-Pol polyprotein3.4.23.160.445
1kqpADJNH(3)-dependent NAD(+) synthetase6.3.1.50.445
1djnADPTrimethylamine dehydrogenase1.5.8.20.444
1rdwLARActin, alpha skeletal muscle/0.444
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3d83GK6Mitogen-activated protein kinase 14/0.444
3nnuEDBMitogen-activated protein kinase 14/0.444
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.444
2cduFADNADH oxidase/0.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.443
4gncASORegucalcin3.1.1.170.443
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.442
4a61ANPPlasmid segregation protein ParM/0.442
4u03GTPCyclic GMP-AMP synthase/0.442
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.441
3ugc046Tyrosine-protein kinase JAK2/0.441
2izrBRKCasein kinase I isoform gamma-32.7.11.10.440
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.440
3t9aANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.440