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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3gcuR48Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3gcuR48Mitogen-activated protein kinase 14/1.000
3hv4L51Mitogen-activated protein kinase 14/0.709
3gcvSS6Mitogen-activated protein kinase 14/0.555
1kv2B96Mitogen-activated protein kinase 14/0.534
2yisYISMitogen-activated protein kinase 14/0.530
3p7bP7BMitogen-activated protein kinase 14/0.517
3npcB96Mitogen-activated protein kinase 92.7.11.240.514
3nnuEDBMitogen-activated protein kinase 14/0.513
3p7aP7AMitogen-activated protein kinase 14/0.510
2puuG2GMitogen-activated protein kinase 14/0.507
3uvr06FMitogen-activated protein kinase 14/0.504
3lfbZ87Mitogen-activated protein kinase 14/0.501
3p5kP5KMitogen-activated protein kinase 14/0.498
3hv6R39Mitogen-activated protein kinase 14/0.490
3hv71AUMitogen-activated protein kinase 14/0.489
3p79P79Mitogen-activated protein kinase 14/0.489
3d83GK6Mitogen-activated protein kinase 14/0.486
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.485
1wbsLI2Mitogen-activated protein kinase 14/0.484
1wbtWBTMitogen-activated protein kinase 14/0.482
3nnxEDDMitogen-activated protein kinase 14/0.482
1w82L10Mitogen-activated protein kinase 14/0.481
3nnwEDDMitogen-activated protein kinase 14/0.481
3p7cP7CMitogen-activated protein kinase 14/0.476
3p78P78Mitogen-activated protein kinase 14/0.469
1kv1BMUMitogen-activated protein kinase 14/0.464
3gi3B10Mitogen-activated protein kinase 14/0.464
3e9319BMitogen-activated protein kinase 14/0.461
3lffZ83Mitogen-activated protein kinase 14/0.458
2yiwYIWMitogen-activated protein kinase 14/0.457
3cs9NILTyrosine-protein kinase ABL12.7.10.20.457
3k3jF4CMitogen-activated protein kinase 14/0.456
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2e2b406Tyrosine-protein kinase ABL12.7.10.20.449
3o8uBMUMitogen-activated protein kinase 14/0.446
1hk1T44Serum albumin/0.444
3uwqU5POrotidine 5'-phosphate decarboxylase/0.444
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.443
1wbvLI3Mitogen-activated protein kinase 14/0.442
1wbnL09Mitogen-activated protein kinase 14/0.441