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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3g5eQ74Aldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3g5eQ74Aldose reductase1.1.1.211.000
3ghuLDTAldose reductase1.1.1.210.762
1z3n3NAAldose reductase1.1.1.210.760
2qxwLDTAldose reductase1.1.1.210.724
1us0LDTAldose reductase1.1.1.210.716
1t40ID5Aldose reductase1.1.1.210.710
2i16LDTAldose reductase1.1.1.210.709
2hvnZSTAldose reductase1.1.1.210.701
2hv5ZSTAldose reductase1.1.1.210.692
3ghsLDTAldose reductase1.1.1.210.689
3ghtLDTAldose reductase1.1.1.210.687
2i17LDTAldose reductase1.1.1.210.683
3ghrLDTAldose reductase1.1.1.210.681
2duxZSTAldose reductase1.1.1.210.680
2dv0ZSTAldose reductase1.1.1.210.673
2fz8ZSTAldose reductase1.1.1.210.673
2hvoZSTAldose reductase1.1.1.210.669
1pwlBFIAldose reductase1.1.1.210.667
2pzn393Aldose reductase1.1.1.210.652
3mb9ZSTAldose reductase1.1.1.210.649
2pdp393Aldose reductase1.1.1.210.635
2pdg47DAldose reductase1.1.1.210.628
2pdxZSTAldose reductase1.1.1.210.626
2pdiZSTAldose reductase1.1.1.210.624
2duzZSTAldose reductase1.1.1.210.619
2fz9ZSTAldose reductase1.1.1.210.618
2iki388Aldose reductase1.1.1.210.617
2pdmZSTAldose reductase1.1.1.210.610
2pdbZSTAldose reductase1.1.1.210.608
2pd5ZSTAldose reductase1.1.1.210.602
2pdh47DAldose reductase1.1.1.210.600
3t423T4Aldose reductase1.1.1.210.600
1z8962PAldose reductase1.1.1.210.598
2pdu393Aldose reductase1.1.1.210.598
2pdc393Aldose reductase1.1.1.210.597
4gca2X9Aldose reductase1.1.1.210.597
3ld5LDTAldose reductase1.1.1.210.594
1t41ID5Aldose reductase1.1.1.210.593
3m0iZSTAldose reductase1.1.1.210.591
2fzdTOLAldose reductase1.1.1.210.589
3lenZSTAldose reductase1.1.1.210.586
3lz5LDTAldose reductase1.1.1.210.586
2pdn47DAldose reductase1.1.1.210.584
3lboLDTAldose reductase1.1.1.210.584
3lqlLDTAldose reductase1.1.1.210.584
3mc5393Aldose reductase1.1.1.210.584
2pdfZSTAldose reductase1.1.1.210.582
1frbZSTAldose reductase-related protein 2/0.579
2ikhLITAldose reductase1.1.1.210.577
4yu153NAldose reductase1.1.1.210.569
1ieiZESAldose reductase1.1.1.210.562
2pdlTOLAldose reductase1.1.1.210.555
3m4h388Aldose reductase1.1.1.210.552
1zuaTOLAldo-keto reductase family 1 member B101.1.10.549
2ikj393Aldose reductase1.1.1.210.545
2pdj393Aldose reductase1.1.1.210.543
3m64393Aldose reductase1.1.1.210.542
1ah3TOLAldose reductase1.1.1.210.536
2is72CLAldose reductase1.1.1.210.535
2pdq47DAldose reductase1.1.1.210.529
2pdwFIDAldose reductase1.1.1.210.499
4ga8SBIAldo-keto reductase family 1 member B101.1.10.499
1ekoI84Aldose reductase1.1.1.210.486
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.481
2f2kTGGAldose reductase1.1.1.210.480
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.479
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.478
1ef3FIDAldose reductase1.1.1.210.476
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.476
2aot2PMHistamine N-methyltransferase2.1.1.80.474
2cekN8TAcetylcholinesterase3.1.1.70.474
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.473
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
1ah0SBIAldose reductase1.1.1.210.471
1lnmDTXBilin-binding protein/0.471
1pwmFIDAldose reductase1.1.1.210.471
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.471
5stdUNNScytalone dehydratase4.2.1.940.471
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.470
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.470
2iqdLPAAldose reductase1.1.1.210.470
4jq4IMNAldo-keto reductase family 1 member C2/0.469
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.469
4fam0SZAldo-keto reductase family 1 member C3/0.468
2xufTZ4Acetylcholinesterase3.1.1.70.467
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.467
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.467
4u163C0Muscarinic acetylcholine receptor M3/0.467
2aovC2MHistamine N-methyltransferase2.1.1.80.466
2fzbTOLAldose reductase1.1.1.210.466
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.466
1e66HUXAcetylcholinesterase3.1.1.70.464
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
5liu388Aldo-keto reductase family 1 member B101.1.10.464
1t47NTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.463
2nvcITAAldose reductase1.1.1.210.463
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.463
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
2inzOHPAldose reductase1.1.1.210.462
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.462
1ry0PG2Aldo-keto reductase family 1 member C3/0.461
1w4lGL8Acetylcholinesterase3.1.1.70.461
3v35NTIAldose reductase1.1.1.210.461
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3f3y4OABile salt sulfotransferase2.8.2.140.460
4lrhFOLFolate receptor alpha/0.460
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.459
4dbs0HVAldo-keto reductase family 1 member C3/0.459
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.459
1lkeDOGBilin-binding protein/0.458
2xugTZ4Acetylcholinesterase3.1.1.70.458
3af1GDPPantothenate kinase2.7.1.330.458
3af4GCPPantothenate kinase2.7.1.330.458
4kn2LYAFolate receptor beta/0.458
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.457
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.457
2f3815MAldo-keto reductase family 1 member C3/0.456
2zsaADPPantothenate kinase2.7.1.330.456
3gsiTHGDimethylglycine oxidase1.5.3.100.456
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
4wevSUZAldo-keto reductase family 1 member B101.1.10.456
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.455
2xujTZ5Acetylcholinesterase3.1.1.70.455
3u2cSUZAldose reductase1.1.1.210.455
4pnrG18Tankyrase-22.4.2.300.455
1upw444Oxysterols receptor LXR-beta/0.454
2pdkSBIAldose reductase1.1.1.210.454
3n0hTOPDihydrofolate reductase1.5.1.30.454
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3zc3FADFerredoxin--NADP reductase1.18.1.20.454
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.454
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.454
4lcnGNGCytidine and deoxycytidylate deaminase zinc-binding region/0.454
1rxjBNIStreptavidin/0.453
1xf0ASDAldo-keto reductase family 1 member C3/0.453
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2g6pHM2Methionine aminopeptidase 1/0.453
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.452
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2ea4F79Methionine aminopeptidase 2/0.452
2pdyFIDAldose reductase1.1.1.210.452
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3szfDCQSulfide-quinone reductase/0.452
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.452
1x8lOXRRetinol dehydratase/0.451
2agtFIDAldose reductase1.1.1.210.451
2xupTZ5Acetylcholinesterase3.1.1.70.451
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
4b65NDPL-ornithine N(5)-monooxygenase/0.451
4dbw511Aldo-keto reductase family 1 member C3/0.451
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.450
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.450
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
4kn0MTXFolate receptor beta/0.450
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.450
1el3I84Aldose reductase1.1.1.210.449
1pqc444Oxysterols receptor LXR-beta/0.449
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.449
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.449
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.449
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.449
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.449
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.449
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.449
1dgbNDPCatalase1.11.1.60.448
2xuiTZ5Acetylcholinesterase3.1.1.70.448
2zs9ADPPantothenate kinase2.7.1.330.448
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.448
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.448
4jtrIZPAldo-keto reductase family 1 member C2/0.448
4kn104JFolate receptor beta/0.448
4msk2C8Tankyrase-12.4.2.300.448
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.447
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.447
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.447
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3s3gTLTAldose reductase1.1.1.210.447
3w2eFADNADH-cytochrome b5 reductase 31.6.2.20.447
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4i5xFLFAldo-keto reductase family 1 member B101.1.10.447
1u65CP0Acetylcholinesterase3.1.1.70.446
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.446
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.446
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.446
2wzySQXSoluble acetylcholine receptor/0.446
3aezGDPPantothenate kinase2.7.1.330.446
3q9bB3NAcetylpolyamine amidohydrolase/0.446
4gabFIDAldo-keto reductase family 1 member B101.1.10.446
1ihiIU5Aldo-keto reductase family 1 member C2/0.445
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.445
3zkyWT4Isopenicillin N synthase1.21.3.10.445
4e0u0MVCyclic dipeptide N-prenyltransferase/0.445
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.444
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.444
1odcA8BAcetylcholinesterase3.1.1.70.444
1ry8RUTAldo-keto reductase family 1 member C3/0.444
1zgbA1EAcetylcholinesterase3.1.1.70.444
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.444
2v0mKLNCytochrome P450 3A4/0.444
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.444
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.444
4phlPILPhosphodiesterase/0.444
4x3uSVRChromobox protein homolog 7/0.444
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1tfz8694-hydroxyphenylpyruvate dioxygenase1.13.11.270.443
2cbqTH2Neocarzinostatin/0.443
3fznD7KBenzoylformate decarboxylase4.1.1.70.443
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.443
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4pnmNU1Tankyrase-22.4.2.300.443
4u140HKMuscarinic acetylcholine receptor M3/0.443
2bu9HFVIsopenicillin N synthase1.21.3.10.442
2vq3NAPMetalloreductase STEAP3/0.442
2vt4P32Beta-1 adrenergic receptor/0.442
3v94WYQPhosphodiesterase/0.442
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.442
2ycxP32Beta-1 adrenergic receptor/0.442
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.441
3uweVJJAldo-keto reductase family 1 member C3/0.441
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4kmzFOLFolate receptor beta/0.441
1esmCOAPantothenate kinase2.7.1.330.440
1pq944BOxysterols receptor LXR-beta/0.440
1q83TZ5Acetylcholinesterase3.1.1.70.440
1zgcA2EAcetylcholinesterase3.1.1.70.440
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
5c1gGDUHisto-blood group ABO system transferase/0.440