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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3g0gRUMDipeptidyl peptidase 4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3g0gRUMDipeptidyl peptidase 4/1.000
3g0bT22Dipeptidyl peptidase 4/0.777
3g0dXIHDipeptidyl peptidase 4/0.727
3ccc7ACDipeptidyl peptidase 4/0.689
3opmLUIDipeptidyl peptidase 4/0.652
4g1f0WGDipeptidyl peptidase 4/0.638
4a5sN7FDipeptidyl peptidase 4/0.634
2aj8SC3Dipeptidyl peptidase 4/0.590
3qbjNXZDipeptidyl peptidase 4/0.556
2rgu356Dipeptidyl peptidase 4/0.532
3f8sPF2Dipeptidyl peptidase 4/0.519
3vjlW94Dipeptidyl peptidase 4/0.516
2j3qTFLAcetylcholinesterase3.1.1.70.511
1umaIN2Prothrombin3.4.21.50.506
1w6jR71Lanosterol synthase5.4.99.70.504
2xuoTZ4Acetylcholinesterase3.1.1.70.503
2ha6SCKAcetylcholinesterase3.1.1.70.502
1h22E10Acetylcholinesterase3.1.1.70.497
3tr05GPGuanylate kinase/0.497
2f3rG5PGuanylate kinase2.7.4.80.495
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.493
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.491
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.489
4qt3RAPPeptidylprolyl isomerase/0.488
4rvfTYDD-mycarose 3-C-methyltransferase/0.488
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.487
2g1s4IGRenin3.4.23.150.487
3wqmB29Diterpene synthase3.1.7.80.487
2g247IGRenin3.4.23.150.486
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.485
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.485
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.485
2gywOBIAcetylcholinesterase3.1.1.70.484
2xlpFADPutative flavin-containing monooxygenase/0.484
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.484
2rlcCHDCholoylglycine hydrolase3.5.1.240.483
3ukfGDUUDP-galactopyranose mutase/0.483
4q0kGA3Phytohormone-binding protein/0.482
3ccbB2YDipeptidyl peptidase 4/0.481
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.481
1r5gAO1Methionine aminopeptidase 2/0.480
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.479
2gv8NDPThiol-specific monooxygenase1.14.130.479
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.478
2ifaFMNUncharacterized protein/0.478
2gesCOKPantothenate kinase2.7.1.330.477
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.476
2gyuHI6Acetylcholinesterase3.1.1.70.476
2jf0HBPAcetylcholinesterase3.1.1.70.476
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.476
3af1GDPPantothenate kinase2.7.1.330.476
4ey7E20Acetylcholinesterase3.1.1.70.476
1q84TZ4Acetylcholinesterase3.1.1.70.475
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.475
3hf3FMNChromate reductase/0.475
3kek3EKCollagenase 33.4.240.475
5cflC2EStimulator of interferon genes protein/0.475
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.474
2gjlFMNNitronate monooxygenase1.13.12.160.474
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.474
4f5yC2EStimulator of interferon genes protein/0.474
4gdcNDPUDP-galactopyranose mutase/0.474
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.474
2b58COADiamine acetyltransferase 1/0.473
4xguADPPutative pachytene checkpoint protein 2/0.473
1odcA8BAcetylcholinesterase3.1.1.70.472
2xpwOTCTetracycline repressor protein class D/0.472
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.472
3kej3EJCollagenase 33.4.240.472
2c20NADUDP-glucose 4-epimerase/0.471
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.471
3mj4URMUDP-galactopyranose mutase/0.471
3nsh957Beta-secretase 13.4.23.460.471
3pkdY10Methionine aminopeptidase 2/0.471
4blrUTPNTPase P4/0.471
4ewo996Beta-secretase 13.4.23.460.471
4i0i957Beta-secretase 13.4.23.460.471
5kwvANPPantothenate synthetase/0.471
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.470
1j36LPRAngiotensin-converting enzyme3.4.15.10.470
1jil485Tyrosine--tRNA ligase/0.470
1n2iPAJPantothenate synthetase6.3.2.10.470
3d91REMRenin3.4.23.150.470
3isjA8DPantothenate synthetase6.3.2.10.470
3pkbY16Methionine aminopeptidase 2/0.470
4eb5PLPCysteine desulfurase IscS 2/0.470
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.470
4h12SAHHistone-lysine N-methyltransferase SETD22.1.1.430.470
1wuaAP8Actin, alpha skeletal muscle/0.469
1x1aSAMC-20 methyltransferase/0.469
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.469
4j4nD44Peptidylprolyl isomerase/0.469
4rvgTYDD-mycarose 3-C-methyltransferase/0.469
6tmn0PIThermolysin3.4.24.270.469
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.468
1szfFMNCytochrome b2, mitochondrial1.1.2.30.468
2cekN8TAcetylcholinesterase3.1.1.70.468
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.468
2q93B21Methionine aminopeptidase/0.468
3b6pTMPThree-prime repair exonuclease 13.1.11.20.468
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.467
3bj7COADiamine acetyltransferase 1/0.467
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.467
3f6sFMNFlavodoxin/0.467
3m4p4ADAsparaginyl-tRNA synthetase, putative/0.467
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.467
1icqOPD12-oxophytodienoate reductase 11.3.1.420.466
1x27ASP_TYR_VAL_HIS_PTRTyrosine-protein kinase Lck2.7.10.20.466
1xdpATPPolyphosphate kinase/0.466
2futH1SHeparin and heparin-sulfate lyase/0.466
2iko7IGRenin3.4.23.150.466
2q94A04Methionine aminopeptidase/0.466
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.466
4bxk1IUAngiotensin-converting enzyme3.2.10.466
4eb7PLPCysteine desulfurase IscS 2/0.466
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.465
1kw9BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.465
1szgFNSCytochrome b2, mitochondrial1.1.2.30.465
1w6hTITPlasmepsin-23.4.23.390.465
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.465
2fxuBIDActin, alpha skeletal muscle/0.465
2geuCOKPantothenate kinase2.7.1.330.465
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.465
2vq7NAPPutative flavin-containing monooxygenase/0.465
4lutDCSAlanine racemase/0.465
4tm4FDAKtzI/0.465
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.464
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.464
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.464
2ikuLIYRenin3.4.23.150.464
2x06NADL-sulfolactate dehydrogenase/0.464
2xujTZ5Acetylcholinesterase3.1.1.70.464
3eksCY9Actin-5C/0.464
4drn0MCPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.464
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.464
2bf4FADNADPH--cytochrome P450 reductase/0.463
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.463
2il2LIXRenin3.4.23.150.463
2q96A18Methionine aminopeptidase/0.463
2xugTZ4Acetylcholinesterase3.1.1.70.463
2zryFNRIsopentenyl-diphosphate delta-isomerase/0.463
3mauEXTPutative sphingosine-1-phosphate lyase/0.463
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.463
4e32DWNMethyltransferase/0.463
4qak2AMRNA 2',3'-cyclic phosphodiesterase/0.463
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.463
1rfuADPPyridoxal kinase2.7.1.350.462
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.462
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.462
3coy53HPantothenate synthetase6.3.2.10.462
3h2sNDPPutative NADH-flavin reductase/0.462
5c3aURMHisto-blood group ABO system transferase/0.462
1icpFMN12-oxophytodienoate reductase 11.3.1.420.461
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.461
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.461
1x1cSAHC-20 methyltransferase/0.461
2pncCLUPrimary amine oxidase, liver isozyme/0.461
2qjoNADBifunctional NMN adenylyltransferase/Nudix hydrolase2.7.7.10.461
3aezGDPPantothenate kinase2.7.1.330.461
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.461
3hl0NADMaleylacetate reductase/0.461
4dro0MDPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.461
4m4922YL-lactate dehydrogenase A chain1.1.1.270.461
1ja0FMNNADPH--cytochrome P450 reductase/0.460
1n0sFLUBilin-binding protein/0.460
3c8aARG_ARG_GLY_LEU_NH2Botulinum neurotoxin type A3.4.24.690.460
4opgFDAConserved Archaeal protein/0.460
5c4nNAPPrecorrin-6A reductase1.3.1.540.460
5e7oMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.460
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.459
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.459
3kmxG00Beta-secretase 13.4.23.460.459
3lqsPSZD-alanine aminotransferase2.6.1.210.459
4d89BXDBeta-secretase 13.4.23.460.459
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.459
4ffw715Dipeptidyl peptidase 4/0.459
1c7oPPGHemolysin/0.458
1g1aNADdTDP-glucose 4,6-dehydratase/0.458
1yqzCOACoenzyme A disulfide reductase/0.458
2g1o2IGRenin3.4.23.150.458
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.458
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.458
2whqHI6Acetylcholinesterase3.1.1.70.458
2xlrFADPutative flavin-containing monooxygenase/0.458
2xukTZ5Acetylcholinesterase3.1.1.70.458
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.458
3gqvNAPEnoyl reductase LovC10.458
3lpjZ75Beta-secretase 13.4.23.460.458
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.458
4de3DN8Beta-lactamase/0.458
4oztP1AEcdysone receptor, putative/0.458
4xfjANPArgininosuccinate synthase/0.458
4yxm2BADNA integrity scanning protein DisA/0.458
1kp3ATPArgininosuccinate synthase6.3.4.50.457
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.457
1q83TZ5Acetylcholinesterase3.1.1.70.457
1qtiGNTAcetylcholinesterase3.1.1.70.457
1xs7MMIBeta-secretase 13.4.23.460.457
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.457
2c6c24IGlutamate carboxypeptidase 23.4.17.210.457
2xuiTZ5Acetylcholinesterase3.1.1.70.457
3ekuCY9Actin-5C/0.457
3jzdNADMaleylacetate reductase/0.457
3l5lFMNXenobiotic reductase/0.457
3l7gM44Xaa-Pro dipeptidase3.4.13.90.457
3ua808WGlutamate receptor 2/0.457
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.457
3zgz84TLeucine--tRNA ligase/0.457
3ziuLSSLeucyl-tRNA synthetase/0.457
4drm0MCPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.457
4opiFDAConserved Archaeal protein/0.457
1obnASVIsopenicillin N synthase1.21.3.10.456
2fxfACODiamine acetyltransferase 1/0.456
2wu4HBPAcetylcholinesterase3.1.1.70.456
2z95NDPGDP-mannose 4,6-dehydratase/0.456
3af0GDPPantothenate kinase2.7.1.330.456
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.456
3pkaY02Methionine aminopeptidase 2/0.456
3qfrFMNNADPH--cytochrome P450 reductase/0.456
4araC56Acetylcholinesterase3.1.1.70.456
4gddNAIUDP-galactopyranose mutase/0.456
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.456
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.456
2c29NAPDihydroflavonol 4-reductase/0.455
2g1y5IGRenin3.4.23.150.455
2x3jATPAcsD/0.455
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.455
3p62FMNPentaerythritol tetranitrate reductase/0.455
3vsxR32Renin3.4.23.150.455
4a6rTA8Probable aminotransferase/0.455
4bfzZVZPantothenate kinase2.7.1.330.455
4bzbDGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.455
4exg916Beta-secretase 13.4.23.460.455
4gd40WSLysine-specific demethylase 4A1.14.110.455
4rxrDCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.455
5af7FADAcyl-CoA dehydrogenase/0.455
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.454
1u65CP0Acetylcholinesterase3.1.1.70.454
1xgjHTCBeta-lactamase3.5.2.60.454
1xvaSAMGlycine N-methyltransferase2.1.1.200.454
2g1r3IGRenin3.4.23.150.454
2xb9XNW3-dehydroquinate dehydratase4.2.1.100.454
2yd0BESEndoplasmic reticulum aminopeptidase 13.4.110.454
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3muoZPRProlyl endopeptidase/0.454
3wycNAPMeso-diaminopimelate D-dehydrogenase1.4.1.160.454
4de10J6Beta-lactamase/0.454
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.454
4j0t6T9Beta-secretase 13.4.23.460.454
1kqgMGDFormate dehydrogenase, nitrate-inducible, major subunit1.1.5.60.453
2evmFC2Methionine aminopeptidase/0.453
2ixkTDOdTDP-4-dehydrorhamnose 3,5-epimerase5.1.3.130.453
2oaeAILDipeptidyl peptidase 4/0.453
2pj4414Carboxypeptidase B/0.453
3b70NAPEnoyl reductase LovC10.453
3bnkFMNFlavoredoxin/0.453
3h0bB35Beta-secretase 13.4.23.460.453
3ioeA7DPantothenate synthetase6.3.2.10.453
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.453
4b68NAPL-ornithine N(5)-monooxygenase/0.453
4ycoFMNtRNA-dihydrouridine(16) synthase/0.453
1eveE20Acetylcholinesterase3.1.1.70.452
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.452
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.452
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.452
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.452
1rneC60Renin3.4.23.150.452
2b3vACODiamine acetyltransferase 1/0.452
2pg0FADAcyl-CoA dehydrogenase/0.452
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.452
2x92X92Angiotensin-converting enzyme3.4.15.10.452
2xuqTZ4Acetylcholinesterase3.1.1.70.452
3f63GTXGlutathione transferase GST1-4/0.452
3iocA5DPantothenate synthetase6.3.2.10.452
3ix3OHNTranscriptional activator protein LasR/0.452
3r95ACOMccE protein/0.452
3r96ACOMccE protein/0.452
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.452
1njjORXOrnithine decarboxylase/0.451
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.451
2ckmAA7Acetylcholinesterase3.1.1.70.451
2qw034Z4-chlorobenzoyl CoA ligase/0.451
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.451
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.451
4ey6GNTAcetylcholinesterase3.1.1.70.451
4loi1YCStimulator of interferon genes protein/0.451
4nauAGSPhosphopantetheine adenylyltransferase/0.451
1a9cGTPGTP cyclohydrolase 13.5.4.160.450
1h73ANPHomoserine kinase2.7.1.390.450
1q6iFK5FKBP-type peptidyl-prolyl cis-trans isomerase FkpA5.2.1.80.450
1qzyTDEMethionine aminopeptidase 2/0.450
1vftDCSAlanine racemase/0.450
1vkgCRIHistone deacetylase 83.5.1.980.450
1z41FMNNADPH dehydrogenase/0.450
1z44FMNNADPH dehydrogenase/0.450
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.450
2g8yNADHydroxycarboxylate dehydrogenase B/0.450
2po7CHDFerrochelatase, mitochondrial4.99.1.10.450
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.450
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.450
2x97RX4Angiotensin-converting enzyme3.4.15.10.450
3cid318Beta-secretase 13.4.23.460.450
3gw9VNILanosterol 14-alpha-demethylase/0.450
3h3qH13Collagen type IV alpha-3-binding protein/0.450
3mhiJ90Carbonic anhydrase 24.2.1.10.450
3ndjJHZMethyltransferase/0.450
3oqfS51Renin3.4.23.150.450
3ufl508Beta-secretase 13.4.23.460.450
4an4DUDPutative glycosyl transferase/0.450
4df2FMNNADPH dehydrogenase/0.450
4ef4C2EStimulator of interferon genes protein/0.450
4g67SAHUncharacterized ACR, COG1565 superfamily/0.450
4qxp1YEStimulator of interferon genes protein/0.450
4uugPXGBranched-chain amino acid aminotransferase, putative/0.450
5c41ACPRibokinase/0.450
1xe55FEPlasmepsin-23.4.23.390.449
1yreCOAUncharacterized protein/0.449
2ea2F77Methionine aminopeptidase 2/0.449
2xpvMIYTetracycline repressor protein class D/0.449
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.449
3fktSIIBeta-secretase 13.4.23.460.449
3hdyGDUUDP-galactopyranose mutase/0.449
3ihkTPPUncharacterized protein/0.449
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3sfh1DIHistone deacetylase 83.5.1.980.449
4la1FADThioredoxin glutathione reductase/0.449
5czySAMEukaryotic huntingtin interacting protein B/0.449
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.449
1nhkCMPNucleoside diphosphate kinase2.7.4.60.448
1s63778Protein farnesyltransferase subunit beta2.5.1.580.448
2r8pT6FTransketolase 1/0.448
2v13C40Renin3.4.23.150.448
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.448
3dv5BAVBeta-secretase 13.4.23.460.448
3lpiZ74Beta-secretase 13.4.23.460.448
3slkNDPPolyketide synthase extender module 2/0.448
3tfyMET_LEU_GLY_PRON-alpha-acetyltransferase 502.3.10.448
3wagTYDGlycosyltransferase/0.448
4arbC57Acetylcholinesterase3.1.1.70.448
4fse0VABeta-secretase 13.4.23.460.448
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.580.448
4j0v1H7Beta-secretase 13.4.23.460.448
4jtqNAPAldo-keto reductase family 1 member C2/0.448
4m83ERYOleandomycin glycosyltransferase2.4.10.448
4xbjIN5Alanine racemase, biosynthetic/0.448
5a0yCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.448
5a0yCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.448
1a5bIGPTryptophan synthase alpha chain/0.447
1gaxVAAValine--tRNA ligase6.1.1.90.447
1ja1FMNNADPH--cytochrome P450 reductase/0.447
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.447
1m9nAMZBifunctional purine biosynthesis protein PURH2.1.2.30.447
1p8dCO1Oxysterols receptor LXR-beta/0.447
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.447
1ut6A8NAcetylcholinesterase3.1.1.70.447
2anb5GPGuanylate kinase2.7.4.80.447
2vkeTACTetracycline repressor protein class D/0.447
3c8bARG_ARG_GLY_ILE_NH2Botulinum neurotoxin type A3.4.24.690.447
3d3xARG_ILE_MET_GLU_NH2Type E botulinum toxin/0.447
3sfy3FYUncharacterized protein/0.447
3vf30GSBeta-secretase 13.4.23.460.447
3vilSA0Beta-glucosidase/0.447
3vyfVYFRenin3.4.23.150.447
4bftZVTPantothenate kinase2.7.1.330.447
4ddyDN6Beta-lactamase/0.447
4fm80UQBeta-secretase 13.4.23.460.447
4j7hTRHPCZA361.3/0.447
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.447
4wljIK2Kynurenine--oxoglutarate transaminase 12.6.1.70.447
1vfsDCSAlanine racemase/0.446
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.446
2b3dFADModulator of drug activity B/0.446
2xveFADPutative flavin-containing monooxygenase/0.446
2ydd2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.446
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.446
3cow52HPantothenate synthetase6.3.2.10.446
3gwfNAPCyclohexanone monooxygenase/0.446
3junAKDPhenazine biosynthesis protein A/B/0.446
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.446
3lqfNADGalactitol dehydrogenase/0.446
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.446
3udj092Beta-secretase 13.4.23.460.446
3vswR31Renin3.4.23.150.446
4c4oNADSADH/0.446
4em4FADCoenzyme A disulfide reductase/0.446
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.446
1o86LPRAngiotensin-converting enzyme3.2.10.445
1wkgPOI[LysW]-aminoadipate semialdehyde transaminase/0.445
1xjqADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.445
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.445
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.445
2ylzFADPhenylacetone monooxygenase1.14.13.920.445
3h3t16HCollagen type IV alpha-3-binding protein/0.445
3sxjSAMPutative methyltransferase/0.445
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.445
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.445
3v0p4GWHisto-blood group ABO system transferase/0.445
3vydVYDRenin3.4.23.150.445
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
3zxiTYATyrosine--tRNA ligase, mitochondrial6.1.1.10.445
4ambDUDPutative glycosyl transferase/0.445
4qnwFMNChanoclavine-I aldehyde reductase easA/0.445
4ycpFMNtRNA-dihydrouridine(16) synthase/0.445
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.444
1s4pGDPGlycolipid 2-alpha-mannosyltransferase/0.444
1udaUFGUDP-glucose 4-epimerase5.1.3.20.444
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.444
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.444
2bjfDXCCholoylglycine hydrolase3.5.1.240.444
2fj1CTCTetracycline repressor protein class D/0.444
2g226IGRenin3.4.23.150.444
2iibC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.444
2jk6FADTrypanothione reductase/0.444
2oz57XYUncharacterized protein/0.444
2vj6VG5Beta-secretase 13.4.23.460.444
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.444
3b4fTUOCarbonic anhydrase 24.2.1.10.444
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.444
3ivxFG6Pantothenate synthetase6.3.2.10.444
3ixk929Beta-secretase 13.4.23.460.444
3m2vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.444
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.444
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.444
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.444
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.444
4i0h1BLBeta-secretase 13.4.23.460.444
4lcjNADC-terminal-binding protein 2/0.444
4mo2FADUDP-galactopyranose mutase/0.444
4nv14TGFormyl transferase/0.444
4tmn0PKThermolysin3.4.24.270.444
1qrpHH0Pepsin A-43.4.23.10.443
1qx4FADNADH-cytochrome b5 reductase 31.6.2.20.443
1r58AO5Methionine aminopeptidase 2/0.443
1zgbA1EAcetylcholinesterase3.1.1.70.443
2c12FADNitroalkane oxidase1.7.3.10.443
2pcmSAHDiphthine synthase/0.443
2pja33ZCarboxypeptidase B/0.443
2viyVG3Beta-secretase 13.4.23.460.443
2x95X95Angiotensin-converting enzyme3.4.15.10.443
2yxuATPPyridoxal kinase2.7.1.350.443
3b1dPLSBetaC-S lyase/0.443
3ojwFMNNADPH--cytochrome P450 reductase/0.443
3qgf46FGenome polyprotein2.7.7.480.443
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.443
4ca73EFAngiotensin-converting enzyme3.4.15.10.443
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.443
4fliY16Methionine aminopeptidase 1/0.443
4g090VDHistidinol dehydrogenase/0.443
4gsuDWZL,D-transpeptidase 22.3.20.443
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.443
4kcfAKMFAD-dependent oxidoreductase/0.443
4m0f1YKAcetylcholinesterase3.1.1.70.443
4xsvCTPEthanolamine-phosphate cytidylyltransferase2.7.7.140.443
1bdbNADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase/0.442
1ex75GPGuanylate kinase2.7.4.80.442
1me6IVSPlasmepsin-23.4.23.390.442
1n77ATPGlutamate--tRNA ligase6.1.1.170.442
1wur8DGGTP cyclohydrolase 1/0.442
1x1dSAHC-20 methyltransferase/0.442
2draATPCCA-adding enzyme2.7.7.720.442
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.442
2rqfJH3Hemolymph juvenile hormone binding protein/0.442
2wzySQXSoluble acetylcholine receptor/0.442
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.442
2xy3DUPSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.442
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
2zsaADPPantothenate kinase2.7.1.330.442
2zsbADPPantothenate kinase2.7.1.330.442
3b6zCO7Enoyl reductase LovC10.442
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.442
3nxqRX4Angiotensin-converting enzyme3.2.10.442
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.442
4b63NAPL-ornithine N(5)-monooxygenase/0.442
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.442
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.442
4iktTFVMethionine aminopeptidase 1/0.442
4jq3NAPAldo-keto reductase family 1 member C2/0.442
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.442
4qg1DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.442
4rphGDUUDP-galactopyranose mutase5.4.99.90.442
4wdgA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
4wxfPLGSerine hydroxymethyltransferase/0.442
1dgmADNAdenosine kinase2.7.1.200.441
1fecFADTrypanothione reductase1.8.1.120.441
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.441
1icqFMN12-oxophytodienoate reductase 11.3.1.420.441
1qpl587Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.441
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.441
1tehNADAlcohol dehydrogenase class-31.1.1.10.441
1w4lGL8Acetylcholinesterase3.1.1.70.441
1wxjIPLTryptophan synthase alpha chain/0.441
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.441
2gg3U13Methionine aminopeptidase/0.441
2gvdFKPAdenylate cyclase type 2/0.441
2gvdFKPAdenylate cyclase type 5/0.441
2i4qUA4Renin3.4.23.150.441
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.441
2xupTZ5Acetylcholinesterase3.1.1.70.441
2xvfFADPutative flavin-containing monooxygenase/0.441
2z9dFMNFMN-dependent NADH-azoreductase/0.441
3ai3NDPNADPH-sorbose reductase/0.441
3f90FMNFlavodoxin/0.441
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.441
3qviK95HAP protein/0.441
3qwbNDPProbable quinone oxidoreductase1.6.5.50.441
3rsv3RSBeta-secretase 13.4.23.460.441
3skgPB8Beta-secretase 13.4.23.460.441
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.441
4awtFMNNADH:flavin oxidoreductase Sye1/0.441
4frkDWDBeta-secretase 13.4.23.460.441
4gid0GHBeta-secretase 13.4.23.460.441
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.441
4jxrACOAcetyltransferase/0.441
5ah5LSSLeucine--tRNA ligase/0.441
5dldUD1UDP-N-Acetylglucosamine 2-epimerase/0.441
4u140HKMuscarinic acetylcholine receptor M3/0.441
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.440
1dx6GNTAcetylcholinesterase3.1.1.70.440
1f8wFADNADH peroxidase1.11.1.10.440
1h69ARHNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1lbcCYZGlutamate receptor 2/0.440
1lbm137N-(5'-phosphoribosyl)anthranilate isomerase5.3.1.240.440
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.440
1s4oGDPGlycolipid 2-alpha-mannosyltransferase/0.440
1tllFMNNitric oxide synthase, brain1.14.13.390.440
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.440
2cjfRP43-dehydroquinate dehydratase4.2.1.100.440
2hdjNDPAldo-keto reductase family 1 member C2/0.440
2vqbFADPutative flavin-containing monooxygenase/0.440
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.440
3ivmZPRProlyl endopeptidase/0.440
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.440
3ohh3HHBeta-secretase 13.4.23.460.440
3oqkS52Renin3.4.23.150.440
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
3v0o4GWHisto-blood group ABO system transferase/0.440
4ddhMS0Pantothenate synthetase6.3.2.10.440
4du6GTPGTP cyclohydrolase 1/0.440
4fkzUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.440
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.440
4tlzNAPKtzI/0.440
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
4zwmPLPOrnithine aminotransferase, mitochondrial, putative/0.440
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.440
5hg0SAMPantothenate synthetase/0.440