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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3fzwEQUSteroid Delta-isomerase5.3.3.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3fzwEQUSteroid Delta-isomerase5.3.3.11.000
1e3vDXCSteroid Delta-isomerase5.3.3.10.638
1e3rANDSteroid Delta-isomerase5.3.3.10.584
3owsEQUSteroid Delta-isomerase5.3.3.10.579
3owyEQUSteroid Delta-isomerase5.3.3.10.579
1ogxEQUSteroid Delta-isomerase5.3.3.10.570
3iptEQUSteroid Delta-isomerase5.3.3.10.560
1gs3EQUSteroid Delta-isomerase5.3.3.10.525
3owuEQUSteroid Delta-isomerase5.3.3.10.520
1oh0EQUSteroid Delta-isomerase5.3.3.10.515
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.504
1cqsEQUSteroid Delta-isomerase5.3.3.10.501
1w6yEQUSteroid Delta-isomerase5.3.3.10.499
1qjgEQUSteroid Delta-isomerase5.3.3.10.495
3da24MDCarbonic anhydrase 134.2.1.10.495
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.494
2po7CHDFerrochelatase, mitochondrial4.99.1.10.490
1o6qR17Squalene--hopene cyclase4.2.1.1290.487
1x8lOXRRetinol dehydratase/0.485
2zb8IMNProstaglandin reductase 21.3.1.480.485
1x1cSAHC-20 methyltransferase/0.482
2x9dITCTetracycline repressor protein class D/0.482
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.482
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.480
3c3xNAPEugenol synthase 11.1.1.3180.478
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.477
1lf3EH5Plasmepsin-23.4.23.390.476
3uwlFOZThymidylate synthase/0.475
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.475
3g5hYTTMycocyclosin synthase1.14.21.90.474
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.474
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.473
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.473
3bgxMEFThymidylate synthase/0.472
3t8xT8XT-cell surface glycoprotein CD1b/0.472
3sn6P0GBeta-2 adrenergic receptor/0.471
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.470
4ict1EDMycocyclosin synthase1.14.21.90.470
1hfqMOTDihydrofolate reductase1.5.1.30.469
1ohoEQUSteroid Delta-isomerase5.3.3.10.469
3gobHXXDdmC/0.469
4ipw1G7Mycocyclosin synthase1.14.21.90.469
1dnaCB3Thymidylate synthase/0.468
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.468
5irnADPNucleotide binding oligomerization domain containing 2/0.468
3up3XCAaceDAF-12/0.467
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.466
1eioGCHGastrotropin/0.465
2xviFADPutative flavin-containing monooxygenase/0.465
4bb3KKAIsopenicillin N synthase1.21.3.10.465
4bfzZVZPantothenate kinase2.7.1.330.465
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.464
4ez8DHFThymidylate synthase2.1.1.450.464
3oqfS51Renin3.4.23.150.463
3qm4PN0Cytochrome P450 2D6/0.463
1fmjRTLRetinol dehydratase/0.462
1rd4L08Integrin alpha-L/0.462
2in6839Wee1-like protein kinase2.7.10.20.462
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.462
4o701QKBromodomain-containing protein 4/0.462
2hw2RFPRifampin ADP-ribosyl transferase/0.461
4h9753SDihydrofolate reductase1.5.1.30.461
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.460
2iyaZIOOleandomycin glycosyltransferase/0.460
1jutLYDThymidylate synthase/0.459
1rf9DBRCamphor 5-monooxygenase1.14.15.10.459
3nmpPYVAbscisic acid receptor PYL2/0.459
3p3zP3ZPutative cytochrome P450/0.459
4g48PZBMycocyclosin synthase1.14.21.90.459
4ktkKTKCytochrome P450/0.459
3drcMTXDihydrofolate reductase1.5.1.30.458
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.458
4uymVOR14-alpha sterol demethylase Cyp51B/0.458
1zeoC01Peroxisome proliferator-activated receptor gamma/0.457
2idkC2FGlycine N-methyltransferase2.1.1.200.457
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.457
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.457
3gkjHC3Niemann-Pick C1 protein/0.457
4bfxZVXPantothenate kinase2.7.1.330.457
4dh60KNBeta-secretase 13.4.23.460.457
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.456
1mvsDTMDihydrofolate reductase1.5.1.30.456
5iqeGNPBifunctional AAC/APH2.3.10.456
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
1o6rR19Squalene--hopene cyclase4.2.1.1290.455
2dw4FADLysine-specific histone demethylase 1A10.455
4jx1CAHCamphor 5-monooxygenase1.14.15.10.455
1opbRETRetinol-binding protein 2/0.454
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.454
2cl5BIECatechol O-methyltransferase2.1.1.60.454
2gv8NDPThiol-specific monooxygenase1.14.130.454
2zb45OPProstaglandin reductase 21.3.1.480.454
3ezpB3NHistone deacetylase 83.5.1.980.454
3vtcTK3Vitamin D3 receptor/0.454
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.454
4kbyC2EStimulator of interferon genes protein/0.454
4psbGA3Cytokinin-specific binding protein/0.454
1fmlRTLRetinol dehydratase/0.453
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.453
3akzGSUGlutamate--tRNA ligase 2/0.453
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.453
3vt8YI3Vitamin D3 receptor/0.453
4dbs0HVAldo-keto reductase family 1 member C3/0.453
4g1d0VKVitamin D3 receptor A/0.453
4nmbFADBifunctional protein PutA/0.453
5kgpACOPredicted acetyltransferase/0.453
4bftZVTPantothenate kinase2.7.1.330.452
4rupH97Vitamin D3 receptor A/0.452
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.451
3kpzZNEVitamin D3 receptor/0.451
3lu8IQXSerum albumin/0.451
3vgnFNNSteroid Delta-isomerase5.3.3.10.451
3zeiAWHO-acetylserine sulfhydrylase/0.451
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.451
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.451
4nmdFDABifunctional protein PutA/0.451
4k5y1Q5Corticotropin-releasing factor receptor 1/0.451
1culFOKAdenylate cyclase type 2/0.450
1culFOKAdenylate cyclase type 5/0.450
1ek2CDUBifunctional epoxide hydrolase 2/0.450
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.450
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.450
2d29FADAcyl-CoA dehydrogenase/0.450
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.450
3p9tTCLRepressor/0.450
3vrwYS5Vitamin D3 receptor/0.450
3w0aDS5Vitamin D3 receptor/0.450
4dsbA8SAbscisic acid receptor PYL3/0.450
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.450
4h9506UDihydrofolate reductase1.5.1.30.450
4jlm1NNDeoxycytidine kinase2.7.1.740.450
4xwtU5PRibonuclease J/0.450
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2w4qCBWProstaglandin reductase 21.3.1.480.449
2zjmF1MBeta-secretase 13.4.23.460.449
3d7kD7KBenzaldehyde lyase/0.449
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.449
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.449
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4bfvZVVPantothenate kinase2.7.1.330.449
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.449
4ead0NPThymidine phosphorylase2.4.2.40.449
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.449
4l8u9AZSerum albumin/0.449
4nieNBHNuclear receptor ROR-gamma/0.449
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.449
1h36R88Squalene--hopene cyclase4.2.1.1290.448
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.448
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.448
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.448
2vn0TDZCytochrome P450 2C8/0.448
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
3sp9IL2Peroxisome proliferator-activated receptor delta/0.448
3ubaHC4Lactoperoxidase1.11.1.70.448
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4dbw511Aldo-keto reductase family 1 member C3/0.448
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.448
4qa0SHHHistone deacetylase 83.5.1.980.448
5g53NECAdenosine receptor A2a/0.448
1dhfFOLDihydrofolate reductase1.5.1.30.447
1mznBM6Retinoic acid receptor RXR-alpha/0.447
2hc4VDXVitamin D3 receptor A/0.447
2y6fM9FIsopenicillin N synthase1.21.3.10.447
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3h3sH15Collagen type IV alpha-3-binding protein/0.447
3tdaPN0Cytochrome P450 2D6/0.447
3vt5YI2Vitamin D3 receptor/0.447
3vt65YIVitamin D3 receptor/0.447
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.447
4g1y0VOVitamin D3 receptor A/0.447
4ia1BIVVitamin D3 receptor A/0.447
4j7xSASSepiapterin reductase1.1.1.1530.447
4q0a4OAVitamin D3 receptor A/0.447
4zm6ACON-acetyl-beta-D glucosaminidase/0.447
1h35R01Squalene--hopene cyclase4.2.1.1290.446
1jraFADFAD-linked sulfhydryl oxidase ERV21.8.3.20.446
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
2ij7TPFMycocyclosin synthase1.14.21.90.446
3a783EVVitamin D3 receptor/0.446
3ekuCY9Actin-5C/0.446
3gfbNADL-threonine 3-dehydrogenase/0.446
3p99LNPLanosterol 14-alpha-demethylase/0.446
3r6pA8SAbscisic acid receptor PYL10/0.446
3rpnGTXGlutathione S-transferase kappa 12.5.1.180.446
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.446
4jdaA9SAbscisic acid receptor PYL3/0.446
1blzACVIsopenicillin N synthase1.21.3.10.445
1pq944BOxysterols receptor LXR-beta/0.445
1rk3VDXVitamin D3 receptor/0.445
1tysDHFThymidylate synthase/0.445
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.445
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.445
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.445
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.445
3h2sNDPPutative NADH-flavin reductase/0.445
4b1fKRHGlutamate racemase/0.445
4g1z0VPVitamin D3 receptor A/0.445
4j6cSTRCytochrome P450 monooxygenase/0.445
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.444
1drbMTXDihydrofolate reductase1.5.1.30.444
1jolFFODihydrofolate reductase1.5.1.30.444
1qrpHH0Pepsin A-43.4.23.10.444
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.444
2gpvOHTEstrogen-related receptor gamma/0.444
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
2xtbKRMAdenosine kinase, putative/0.444
3ixp834Ecdysone receptor/0.444
3pqbVGPPutative oxidoreductase/0.444
3u8hBHPPhospholipase A2, membrane associated/0.444
3vruYS3Vitamin D3 receptor/0.444
4h9614QDihydrofolate reductase1.5.1.30.444
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4l9kEHFSerum albumin/0.444
4l9q9TPSerum albumin/0.444
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.443
2hcdBIVVitamin D3 receptor A/0.443
2hkoFADLysine-specific histone demethylase 1A10.443
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3v94WYQPhosphodiesterase/0.443
3vtbTKAVitamin D3 receptor/0.443
3w0hW12Vitamin D3 receptor/0.443
4bfyZVYPantothenate kinase2.7.1.330.443
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.443
4ia7BIVVitamin D3 receptor A/0.443
4ltsLTSNicotinamide phosphoribosyltransferase2.4.2.120.443
4ure1PSCyclohexanol dehydrogenase/0.443
4zj8SUVOrexin receptor type 1/0.443
1hvyD16Thymidylate synthase2.1.1.450.442
1ie9VDXVitamin D3 receptor/0.442
1kt3RTLRetinol-binding protein 4/0.442
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
1xddAAYIntegrin alpha-L/0.442
2lbaCHOFatty acid binding protein 6/0.442
2o4jVD4Vitamin D3 receptor/0.442
2vcmM11Isopenicillin N synthase1.21.3.10.442
3cobADPKinesin heavy chain-like protein/0.442
3dl9V2HVitamin D 25-hydroxylase/0.442
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.442
3oafOAGDihydrofolate reductase1.5.1.30.442
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.442
4nm9FADBifunctional protein PutA/0.442
4uyg73BBromodomain-containing protein 2/0.442
5dozNDPJamJ/0.442
5stdUNNScytalone dehydratase4.2.1.940.442
2bbqPFGThymidylate synthase/0.441
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.441
2rqfJH3Hemolymph juvenile hormone binding protein/0.441
2xy93ESAngiotensin-converting enzyme3.2.10.441
3h18PMSEsterase/lipase/0.441
3q9bB3NAcetylpolyamine amidohydrolase/0.441
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.441
4b1rITCTetracycline repressor protein class D/0.441
4gn6TYLLactoperoxidase1.11.1.70.441
4qa1B3NHistone deacetylase 83.5.1.980.441
4x5iFOLDihydrofolate reductase1.5.1.30.441
5iqbGNPBifunctional AAC/APH2.3.10.441
4s0vSUVOrexin receptor type 2/0.441
1fm4DXCMajor pollen allergen Bet v 1-L/0.440
1rb2FOLDihydrofolate reductase1.5.1.30.440
1re9DSOCamphor 5-monooxygenase1.14.15.10.440
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.440
2lfoGCHFatty acid-binding protein, liver/0.440
3h3qH13Collagen type IV alpha-3-binding protein/0.440
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.440
3qgd26SGenome polyprotein2.7.7.480.440
4ap1NAPSteroid monooxygenase/0.440
4ea13RXDehydrosqualene synthase/0.440
4eiyZMAAdenosine receptor A2a/0.440
4jq4IMNAldo-keto reductase family 1 member C2/0.440
4rn615UProthrombin3.4.21.50.440
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.440