sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3fui | 812 | Leukotriene A-4 hydrolase | 3.3.2.6 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3fui | 812 | Leukotriene A-4 hydrolase | 3.3.2.6 | 1.000 | |
| 3ful | 52D | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.760 | |
| 4rsy | B3N | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.643 | |
| 3chs | 4BU | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.622 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.590 | |
| 3fuj | 00G | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.579 | |
| 3fu5 | 492 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.524 | |
| 3fuh | BES | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.474 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.472 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.466 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3chr | 4BS | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.459 | |
| 4e2z | JHZ | Methyltransferase | / | 0.458 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.456 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 2cb3 | MLD | Peptidoglycan-recognition protein LE | / | 0.454 | |
| 3kmy | D8Y | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4mbs | MRV | C-C chemokine receptor type 5 | / | 0.454 | |
| 3br9 | DEY | Genome polyprotein | 2.7.7.48 | 0.453 | |
| 3udk | 095 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.450 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.450 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.448 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.448 | |
| 1jcq | 739 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.447 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.446 | |
| 4dyn | 0MR | Nucleoprotein | / | 0.446 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.446 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.445 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.445 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.445 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.444 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.444 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.443 | |
| 4lc7 | 1WP | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.443 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.443 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.442 | |
| 4o7u | THF | Thymidylate synthase | / | 0.442 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4e2y | JHZ | Methyltransferase | / | 0.441 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3dr4 | G4M | GDP-perosamine synthase | / | 0.440 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 |