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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3fsuC2F5,10-methylenetetrahydrofolate reductase1.5.1.20

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3fsuC2F5,10-methylenetetrahydrofolate reductase1.5.1.201.000
1zp4C2F5,10-methylenetetrahydrofolate reductase1.5.1.200.515
2fmn4HF5,10-methylenetetrahydrofolate reductase1.5.1.200.510
3mdvCL6Cholesterol 24-hydroxylase/0.486
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.473
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.473
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.468
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
3p3zP3ZPutative cytochrome P450/0.468
3tk3CPZCytochrome P450 2B41.14.14.10.468
3qly55VUncharacterized protein/0.467
4h3qANPMitogen-activated protein kinase 12.7.11.240.467
2hcdBIVVitamin D3 receptor A/0.465
3fc152PMitogen-activated protein kinase 14/0.465
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
4xe606UDihydrofolate reductase1.5.1.30.465
4xiwAZMCarbonic anhydrase, alpha type/0.465
2zbaZBATrichothecene 3-O-acetyltransferase/0.464
3ixp834Ecdysone receptor/0.464
4gevCB3Thymidylate synthase/0.464
1m13HYFNuclear receptor subfamily 1 group I member 2/0.462
1tl7FOKAdenylate cyclase type 2/0.462
1tl7FOKAdenylate cyclase type 5/0.462
1v7aFRCAdenosine deaminase3.5.4.40.462
2uxpCLMHTH-type transcriptional regulator TtgR/0.462
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1tl1H18Gag-Pol polyprotein2.7.7.490.461
3c3xNAPEugenol synthase 11.1.1.3180.461
4ib4ERM5-hydroxytryptamine receptor 2B/0.461
1ppjANYCytochrome b/0.460
1rx8FOLDihydrofolate reductase1.5.1.30.460
1tduCB3Thymidylate synthase/0.460
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.460
3nj0PYVAbscisic acid receptor PYL2/0.460
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
2cd8PXICytochrome P450 monooxygenase PikC/0.459
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.459
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.459
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
2bx8AZQSerum albumin/0.458
2hamC33Vitamin D3 receptor/0.458
2wugHPK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.458
1hk1T44Serum albumin/0.457
1i58ACPChemotaxis protein CheA2.7.13.30.457
1ie8KH1Vitamin D3 receptor/0.457
2zjwREFCasein kinase II subunit alpha2.7.11.10.457
3irxUDRGag-Pol polyprotein2.7.7.490.457
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.457
4ia3BIVVitamin D3 receptor A/0.457
4nb6444Nuclear receptor ROR-gamma/0.457
2ev9NAPShikimate dehydrogenase (NADP(+))/0.456
2om9AJAPeroxisome proliferator-activated receptor gamma/0.456
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.456
3hz5Z64Heat shock protein HSP 90-alpha/0.456
3i0rRT3Gag-Pol polyprotein2.7.7.490.456
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2d29FADAcyl-CoA dehydrogenase/0.455
3c3dFO12-phospho-L-lactate transferase/0.455
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.455
1s19MC9Vitamin D3 receptor/0.454
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.454
4enhFVXCholesterol 24-hydroxylase/0.454
4iui1GQEstrogen receptor/0.454
1ie9VDXVitamin D3 receptor/0.453
1kzjCB3Thymidylate synthase/0.453
2bxoOPBSerum albumin/0.453
2w98P1ZProstaglandin reductase 21.3.1.480.453
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
3w5tLHPVitamin D3 receptor/0.453
4iteTEYVitamin D3 receptor/0.453
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.452
3ctj320Hepatocyte growth factor receptor2.7.10.10.452
3kpzZNEVitamin D3 receptor/0.452
4e730NRMitogen-activated protein kinase 82.7.11.240.452
4ii5ADPCyclin-dependent kinase 22.7.11.220.452
4jlj1NMDeoxycytidine kinase2.7.1.740.452
4pd6URINucleoside permease/0.452
4ryvZEAProtein LlR18A/0.452
4zp1TPPPyruvate decarboxylase4.1.1.10.452
4i7fNVEGag-Pol polyprotein2.7.7.490.451
4j6bPLOCytochrome P450 monooxygenase/0.451
4z69DIFSerum albumin/0.451
1hfqMOTDihydrofolate reductase1.5.1.30.450
1tl3H20Gag-Pol polyprotein2.7.7.490.450
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.450
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.450
3jw5TOPDihydrofolate reductase/0.450
3nr4PYVAbscisic acid receptor PYL2/0.450
4q71FADBifunctional protein PutA/0.450
3emlZMAAdenosine receptor A2a/0.450
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1osvCHCBile acid receptor/0.449
1yw2PGJMitogen-activated protein kinase 14/0.449
3h3sH15Collagen type IV alpha-3-binding protein/0.449
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
4ia7BIVVitamin D3 receptor A/0.449
4m9aFDAAcyl-CoA dehydrogenase/0.449
4pkl1GHUncharacterized protein/0.449
1g4sTPSThiamine-phosphate synthase/0.448
1kqwRTLCellular retinol-binding protein type II/0.448
1phgMYTCamphor 5-monooxygenase1.14.15.10.448
1uykPUXHeat shock protein HSP 90-alpha/0.448
2hasC3OVitamin D3 receptor/0.448
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.448
4ap1NAPSteroid monooxygenase/0.448
1dkfBMSRetinoic acid receptor alpha/0.447
1fmlRTLRetinol dehydratase/0.447
1re9DSOCamphor 5-monooxygenase1.14.15.10.447
1s6qTPBGag-Pol polyprotein2.7.7.490.447
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.447
2hw2RFPRifampin ADP-ribosyl transferase/0.447
3a4pDFQHepatocyte growth factor receptor2.7.10.10.447
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3h1jSMACytochrome b/0.447
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3mtfA3FActivin receptor type-12.7.11.300.447
3roc29AMitogen-activated protein kinase 14/0.447
3sa27DRDihydrofolate reductase/0.447
3vtdTKDVitamin D3 receptor/0.447
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1f4fTP3Thymidylate synthase/0.446
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
1uyePU9Heat shock protein HSP 90-alpha/0.446
2oa1FADFlavin-dependent tryptophan halogenase RebH1.14.19.90.446
3ol5SAWCamphor 5-monooxygenase1.14.15.10.446
3oqfS51Renin3.4.23.150.446
3zk5Z18Cytochrome P450 monooxygenase PikC/0.446
4g1y0VOVitamin D3 receptor A/0.446
4qa2SHHHistone deacetylase 83.5.1.980.446
1rkhVD2Vitamin D3 receptor/0.445
2bj4OHTEstrogen receptor/0.445
2hb8MVDVitamin D3 receptor/0.445
2ittAEEEpidermal growth factor receptor2.7.10.10.445
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.445
2uxoTACHTH-type transcriptional regulator TtgR/0.445
2vzmNRBCytochrome P450 monooxygenase PikC/0.445
3drcMTXDihydrofolate reductase1.5.1.30.445
3inxJZCHeat shock protein HSP 90-alpha/0.445
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.445
3jwm5WBDihydrofolate reductase/0.445
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.445
3p6pA6BCamphor 5-monooxygenase1.14.15.10.445
3r3b4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.445
3s1dZIRCytokinin dehydrogenase 11.5.99.120.445
4g3rCAMCamphor 5-monooxygenase1.14.15.10.445
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.445
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1uy7PU4Heat shock protein HSP 90-alpha/0.444
2dwpACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.444
3dl9V2HVitamin D 25-hydroxylase/0.444
3gc9B45Mitogen-activated protein kinase 112.7.11.240.444
3tmz06XCytochrome P450 2B41.14.14.10.444
3vt7VDXVitamin D3 receptor/0.444
4klaCHDFerrochelatase, mitochondrial4.99.1.10.444
4o761M3Bromodomain-containing protein 4/0.444
4rupH97Vitamin D3 receptor A/0.444
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1ezvSMACytochrome b/0.443
1ikyMSDGag-Pol polyprotein2.7.7.490.443
1r2jFADFkbI/0.443
1zdwFLVPrenyltransferase/0.443
1zrzBI1Protein kinase C iota type2.7.11.130.443
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.443
2vbdV10Isopenicillin N synthase1.21.3.10.443
2z97CAMCamphor 5-monooxygenase1.14.15.10.443
3ddw055Glycogen phosphorylase, liver form2.4.1.10.443
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
3vtbTKAVitamin D3 receptor/0.443
3w0jT08Vitamin D3 receptor/0.443
4efuEFUHeat shock protein HSP 90-alpha/0.443
4ez8DHFThymidylate synthase2.1.1.450.443
1drbMTXDihydrofolate reductase1.5.1.30.442
1kb9SMACytochrome b/0.442
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1upw444Oxysterols receptor LXR-beta/0.442
1uy9PU6Heat shock protein HSP 90-alpha/0.442
1vi2NADQuinate/shikimate dehydrogenase/0.442
2bunFADAppA protein/0.442
2c7xNRBCytochrome P450 monooxygenase PikC/0.442
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.442
3bfa9ODOdorant binding protein ASP1/0.442
3cv9VDXVitamin D3 dihydroxylase/0.442
3mnrSD1Heat shock protein HSP 90-alpha/0.442
3negPYVAbscisic acid receptor PYL1/0.442
3q92XNBKetohexokinase/0.442
3vruYS3Vitamin D3 receptor/0.442
4aosNAPSteroid monooxygenase/0.442
4jx1CAHCamphor 5-monooxygenase1.14.15.10.442
4odoFK5Peptidyl-prolyl cis-trans isomerase/0.442
1e7aPFLSerum albumin/0.441
1kt3RTLRetinol-binding protein 4/0.441
1nytNAPShikimate dehydrogenase (NADP(+))/0.441
1o5rFR9Adenosine deaminase3.5.4.40.441
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1rfvADPPyridoxal kinase2.7.1.350.441
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.441
1txiTX5Vitamin D3 receptor/0.441
1vruAAPGag-Pol polyprotein2.7.7.490.441
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.441
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.441
3d8vUD1Bifunctional protein GlmU/0.441
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.441
3o6o94MHeat shock protein 83/0.441
3oafOAGDihydrofolate reductase1.5.1.30.441
3w9rA8SAbscisic acid receptor PYL9/0.441
3zw9T1GPeroxisomal bifunctional enzyme1.1.1.350.441
4ejh0QACytochrome P450 2A131.14.14.10.441
4j6cSTRCytochrome P450 monooxygenase/0.441
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.441
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
1dhjMTXDihydrofolate reductase1.5.1.30.440
1klkPMDDihydrofolate reductase1.5.1.30.440
1ndzFR5Adenosine deaminase3.5.4.40.440
1pp9SMACytochrome b/0.440
1s3yTQTDihydrofolate reductase1.5.1.30.440
1umlFR4Adenosine deaminase3.5.4.40.440
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
2ca0PXICytochrome P450 monooxygenase PikC/0.440
2yeiXQIHeat shock protein HSP 90-alpha/0.440
3elySAHMethyltransferase/0.440
3juhANPCasein kinase II subunit alpha2.7.11.10.440
3oquA8SAbscisic acid receptor PYL9/0.440
3p62FMNPentaerythritol tetranitrate reductase/0.440
4dfrMTXDihydrofolate reductase1.5.1.30.440
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.440
4nc3ERM5-hydroxytryptamine receptor 2B/0.440
4nmbFADBifunctional protein PutA/0.440