sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 1.000 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.564 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.514 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.503 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.502 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.502 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.495 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.494 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.493 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.489 | |
| 3v2u | ATP | Protein GAL3 | / | 0.488 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.487 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.487 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.486 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.486 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.485 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.485 | |
| 4isf | 1FX | Glucokinase | 2.7.1.2 | 0.485 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.484 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.484 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.483 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.482 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 4bb2 | STR | Corticosteroid-binding globulin | / | 0.482 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.482 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.480 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.480 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.479 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.478 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.478 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.478 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 1ja0 | FAD | NADPH--cytochrome P450 reductase | / | 0.477 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.477 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.477 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.477 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.476 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.475 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.475 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.474 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.474 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.472 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.472 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.471 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.471 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.470 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.470 | |
| 1c7o | PPG | Hemolysin | / | 0.469 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.469 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.469 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.469 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.469 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.469 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.469 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.468 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.468 | |
| 4y7c | NAP | NADPH--cytochrome P450 reductase | / | 0.468 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.468 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.467 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.467 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.467 | |
| 5d7p | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.467 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.466 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.466 | |
| 2ejz | SAH | Diphthine synthase | / | 0.466 | |
| 3eku | CY9 | Actin-5C | / | 0.466 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.466 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.466 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.466 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.464 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.464 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.464 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.464 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.464 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.464 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.464 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.464 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.464 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 3pn1 | IVH | DNA ligase | / | 0.464 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.464 | |
| 1fml | RTL | Retinol dehydratase | / | 0.463 | |
| 1rxj | BNI | Streptavidin | / | 0.463 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 3cgy | RDC | Virulence sensor histidine kinase PhoQ | 2.7.13.3 | 0.463 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.463 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.462 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.462 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.462 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.462 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.462 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.462 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.461 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.461 | |
| 1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.461 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.461 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.461 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.461 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.461 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.461 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.461 | |
| 5cpm | FNR | NADH:flavin oxidoreductase | / | 0.461 | |
| 1qrt | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.460 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.460 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.460 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.460 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.460 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.460 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.460 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.460 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.460 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.459 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.459 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.459 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.459 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.458 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.458 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.458 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.457 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.457 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.457 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.457 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.457 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.457 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.457 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.457 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.457 | |
| 4nbj | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.457 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.456 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.456 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.456 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.456 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.456 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.456 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.456 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.456 | |
| 3wag | TYD | Glycosyltransferase | / | 0.456 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.456 | |
| 4j7h | TRH | PCZA361.3 | / | 0.456 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.456 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.456 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.455 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.455 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.455 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.455 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.455 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.455 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.455 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.454 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.454 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.454 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.454 | |
| 2dsh | SAH | Diphthine synthase | / | 0.454 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.454 | |
| 3eq6 | BCO | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.454 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.454 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.454 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 4yal | 2AM | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 5d7o | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.454 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.454 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.453 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.453 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.453 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.453 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.453 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.453 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.453 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.453 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.452 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.452 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.452 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.452 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.452 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.452 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 4b6l | 9ZP | Serine/threonine-protein kinase PLK3 | 2.7.11.21 | 0.452 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.452 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.451 | |
| 1lke | DOG | Bilin-binding protein | / | 0.451 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.451 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.451 | |
| 2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.451 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.451 | |
| 2z4w | 749 | Geranylgeranyl pyrophosphate synthase | / | 0.451 | |
| 3b04 | OOP | Isopentenyl-diphosphate delta-isomerase | / | 0.451 | |
| 3hgg | CHD | CmeR | / | 0.451 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.451 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.451 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.451 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.450 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.450 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.450 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.450 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.450 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.450 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.450 | |
| 1amo | FAD | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 1ppj | ANY | Cytochrome b | / | 0.449 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.449 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.449 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.449 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.449 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.449 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.449 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.449 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.449 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.449 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.449 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.449 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.448 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.448 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.448 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.448 | |
| 3ckq | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.448 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.448 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.448 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.448 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.447 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.447 | |
| 2glr | GTX | Glutathione S-transferase P 1 | 2.5.1.18 | 0.447 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.447 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.447 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.447 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.447 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.447 | |
| 3dz7 | O8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.447 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.447 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.447 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.447 | |
| 4zgs | NAD | Putative D-lactate dehydrogenase | / | 0.447 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.447 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.447 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.446 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.446 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.446 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.446 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.446 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.446 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.446 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.446 | |
| 4jxx | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.446 | |
| 4rel | KMP | Glycosyltransferase | / | 0.446 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.445 | |
| 3c1o | NAP | Eugenol synthase | / | 0.445 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.445 | |
| 4hlm | 16S | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.445 | |
| 5ilw | URI | Ribosome inactivating protein | / | 0.445 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.444 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.444 | |
| 1zdw | FLV | Prenyltransferase | / | 0.444 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.444 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.444 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.444 | |
| 2y01 | Y00 | Beta-1 adrenergic receptor | / | 0.444 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.444 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.444 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.444 | |
| 1cjw | COT | Serotonin N-acetyltransferase | / | 0.443 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.443 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.443 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.443 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.443 | |
| 3hl4 | CDC | Choline-phosphate cytidylyltransferase A | / | 0.443 | |
| 3i7v | B4P | AP4A hydrolase | / | 0.443 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.443 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.443 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.443 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.443 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.443 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.442 | |
| 1m8g | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.442 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1qtq | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.442 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.442 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.442 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2hzq | STR | Apolipoprotein D | / | 0.442 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.442 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.442 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.442 | |
| 4jxz | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.442 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.442 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.442 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.442 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.441 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.441 | |
| 2bpo | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.441 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.441 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.441 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.441 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.441 | |
| 3b9l | AZZ | Serum albumin | / | 0.441 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 3nz2 | ACO | Hexapeptide-repeat containing-acetyltransferase | / | 0.441 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.440 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2p6i | SAH | Diphthine synthase | / | 0.440 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.440 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.440 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3f90 | FMN | Flavodoxin | / | 0.440 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.440 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3lzx | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.440 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.440 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.440 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.440 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.440 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.440 |