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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3fl8RARDihydrofolate reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3fl8RARDihydrofolate reductase/1.000
4ele31IDihydrofolate reductase/0.720
4elf35IDihydrofolate reductase/0.635
4elg52JDihydrofolate reductase/0.596
4elb34SDihydrofolate reductase/0.579
4elh53IDihydrofolate reductase/0.556
4elb34RDihydrofolate reductase/0.533
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.522
2qk8MTXDihydrofolate reductase/0.498
1diuBDMDihydrofolate reductase1.5.1.30.495
3fl9TOPDihydrofolate reductase/0.485
1disBDMDihydrofolate reductase1.5.1.30.483
3och2MXDihydrofolate reductase1.5.1.30.480
1jolFFODihydrofolate reductase1.5.1.30.479
1draMTXDihydrofolate reductase1.5.1.30.478
1ddrMTXDihydrofolate reductase1.5.1.30.476
2drcMTXDihydrofolate reductase1.5.1.30.473
4dfrMTXDihydrofolate reductase1.5.1.30.473
1ddsMTXDihydrofolate reductase1.5.1.30.472
1tdrMTXDihydrofolate reductase1.5.1.30.461
1rf7DHFDihydrofolate reductase1.5.1.30.455
4cd2FOLDihydrofolate reductase1.5.1.30.455
1drbMTXDihydrofolate reductase1.5.1.30.453
1rb3MTXDihydrofolate reductase1.5.1.30.452
1dhjMTXDihydrofolate reductase1.5.1.30.448
4xe606UDihydrofolate reductase1.5.1.30.448
5hi6MTXDihydrofolate reductase/0.447
1dyjDDFDihydrofolate reductase1.5.1.30.444
1re7FOLDihydrofolate reductase1.5.1.30.444
3drcMTXDihydrofolate reductase1.5.1.30.443
3syiFADSulfide-quinone reductase/0.443
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.442