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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3f5p741Insulin-like growth factor 1 receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3f5p741Insulin-like growth factor 1 receptor2.7.10.11.000
3w2o03PEpidermal growth factor receptor2.7.10.10.522
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.489
3zk5Z18Cytochrome P450 monooxygenase PikC/0.462
2j7t274Serine/threonine-protein kinase 102.7.11.10.461
4nka2K7Fibroblast growth factor receptor 1/0.461
4anqVGHALK tyrosine kinase receptor2.7.10.10.454
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.450
3gggNADPrephenate dehydrogenase/0.450
3ttjJBIMitogen-activated protein kinase 102.7.11.240.449
2c7xNRBCytochrome P450 monooxygenase PikC/0.446
2c6hPXICytochrome P450 monooxygenase PikC/0.445
2xp2VGHALK tyrosine kinase receptor2.7.10.10.445
4aotGW8Serine/threonine-protein kinase 102.7.11.10.443
3p3e3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.442
1k6cMK1Gag-Pol polyprotein3.4.23.160.441
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4fob0USALK tyrosine kinase receptor2.7.10.10.440