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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3eta351Insulin receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3eta351Insulin receptor2.7.10.11.000
3ctj320Hepatocyte growth factor receptor2.7.10.10.454
4eevL1XHepatocyte growth factor receptor2.7.10.10.448
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.443
3efl706Vascular endothelial growth factor receptor 22.7.10.10.443
4kaoKAOFocal adhesion kinase 12.7.10.20.443