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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3eluSAMMethyltransferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3eluSAMMethyltransferase/1.000
3eldSFGMethyltransferase/0.804
2pxaSAHGenome polyprotein2.7.7.480.665
4k6mSAHGenome polyprotein/0.622
4ctjSAMGenome polyprotein/0.613
3p8z36AGenome polyprotein2.1.1.560.609
2p41SAHGenome polyprotein/0.585
3p8zSAHGenome polyprotein2.1.1.560.582
2px5SAHGenome polyprotein2.7.7.480.580
3p97SAMGenome polyprotein2.1.1.560.567
5jjrSAHGenome polyprotein/0.565
2xbmSAHGenome polyprotein/0.559
2wa2SAMGenome polyprotein/0.555
4ctkSAMGenome polyprotein/0.551
2px2SAHGenome polyprotein2.7.7.480.548
5jjsSAHGenome polyprotein/0.541
2oxtSAMGenome polyprotein/0.539
3elySAHMethyltransferase/0.537
3evcSAHGenome polyprotein2.1.1.560.510
3evgSAHGenome polyprotein2.1.1.560.506
3lkzSFGGenome polyprotein/0.495
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449