sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ekr | PY9 | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.677 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.658 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.632 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.625 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.621 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.614 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.610 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.609 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.592 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.592 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.587 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.586 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.582 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.578 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.576 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.575 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.575 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.574 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.573 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.572 | |
| 1u0z | RDC | Endoplasmin | / | 0.571 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.571 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.568 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.568 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.566 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.565 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.562 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.562 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.560 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.555 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 1qy8 | RDI | Endoplasmin | / | 0.553 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.553 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.552 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.550 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.550 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.549 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.548 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.548 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.546 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.540 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.540 | |
| 2hch | N5A | Endoplasmin | / | 0.539 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.536 | |
| 1u2o | NEC | Endoplasmin | / | 0.534 | |
| 2exl | GDM | Endoplasmin | / | 0.534 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.534 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.534 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.532 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 1qy5 | NEC | Endoplasmin | / | 0.530 | |
| 3ied | AN2 | HSP90 | / | 0.530 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.529 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.529 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 1ysz | NEC | Endoplasmin | / | 0.528 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.528 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.527 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.526 | |
| 2fyp | RDE | Endoplasmin | / | 0.525 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.524 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.524 | |
| 2gfd | RDA | Endoplasmin | / | 0.523 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.522 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 2gqp | PA7 | Endoplasmin | / | 0.520 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 2hg1 | N5O | Endoplasmin | / | 0.517 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.517 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.517 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.516 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.514 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 3rlp | 3RP | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 1u0y | PA7 | Endoplasmin | / | 0.512 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.511 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.510 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.503 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.502 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.500 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.493 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.492 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.489 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.487 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.487 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.486 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.486 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.484 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2yi6 | 6QM | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.482 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.479 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.479 | |
| 2esa | GDM | Endoplasmin | / | 0.478 | |
| 2o1v | ADP | Endoplasmin | / | 0.478 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.476 | |
| 4fcq | 2N6 | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 1yt0 | ADP | Endoplasmin | / | 0.474 | |
| 2o1u | ANP | Endoplasmin | / | 0.474 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.474 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.473 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.473 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.473 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.470 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.469 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 2ye9 | 2D4 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.468 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.467 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.460 | |
| 2cct | 2E1 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 2q8i | RDC | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial | 2.7.11.2 | 0.456 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.456 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.454 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.454 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.451 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.446 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.444 | |
| 2zkj | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.444 | |
| 4dju | 0KK | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.443 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.443 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.443 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 2ye4 | 2FY | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 |