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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3eigMTXDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3eigMTXDihydrofolate reductase1.5.1.31.000
2dhfDZFDihydrofolate reductase1.5.1.30.504
1s3uTQDDihydrofolate reductase1.5.1.30.500
4cd2FOLDihydrofolate reductase1.5.1.30.483
1pd9CO4Dihydrofolate reductase1.5.1.30.478
1dhfFOLDihydrofolate reductase1.5.1.30.474
3oafOAGDihydrofolate reductase1.5.1.30.471
1rb3MTXDihydrofolate reductase1.5.1.30.468
1s3vTQDDihydrofolate reductase1.5.1.30.464
1dr3HBIDihydrofolate reductase1.5.1.30.461
3drcMTXDihydrofolate reductase1.5.1.30.460
1drfFOLDihydrofolate reductase1.5.1.30.459
1tdrMTXDihydrofolate reductase1.5.1.30.459
4dfrMTXDihydrofolate reductase1.5.1.30.459
1hfqMOTDihydrofolate reductase1.5.1.30.454
1ddsMTXDihydrofolate reductase1.5.1.30.453
1mvsDTMDihydrofolate reductase1.5.1.30.452
1ddrMTXDihydrofolate reductase1.5.1.30.450
5cccDDFDihydrofolate reductase1.5.1.30.450
1diuBDMDihydrofolate reductase1.5.1.30.449
3och2MXDihydrofolate reductase1.5.1.30.446
1dhjMTXDihydrofolate reductase1.5.1.30.445
1draMTXDihydrofolate reductase1.5.1.30.444
4h9814QUncharacterized protein/0.444
3s7a684Dihydrofolate reductase1.5.1.30.442
4elb34SDihydrofolate reductase/0.442
4g95OAGDihydrofolate reductase1.5.1.30.442
4ele31IDihydrofolate reductase/0.440