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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3efl706Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3efl706Vascular endothelial growth factor receptor 22.7.10.11.000
3hng8STVascular endothelial growth factor receptor 12.7.10.10.657
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.632
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.620
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.615
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.590
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.586
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.585
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.584
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.581
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.574
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.573
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.573
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.566
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.563
2hyySTITyrosine-protein kinase ABL12.7.10.20.560
4o2z046Mitogen-activated protein kinase/0.557
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.556
2xir00JVascular endothelial growth factor receptor 22.7.10.10.553
1iepSTITyrosine-protein kinase ABL12.7.10.20.549
3eta351Insulin receptor2.7.10.10.549
4aa0AA0Mitogen-activated protein kinase 14/0.546
3hv5R24Mitogen-activated protein kinase 14/0.533
2og81N8Tyrosine-protein kinase Lck2.7.10.20.520
4eyjN61Mitogen-activated protein kinase 132.7.11.240.520
3kq7KQ7Mitogen-activated protein kinase 14/0.518
3ctj320Hepatocyte growth factor receptor2.7.10.10.508
4qrc0LIFibroblast growth factor receptor 42.7.10.10.492
4kaoKAOFocal adhesion kinase 12.7.10.20.491
4eevL1XHepatocyte growth factor receptor2.7.10.10.470
3ce31FNHepatocyte growth factor receptor2.7.10.10.463
4at5MUJBDNF/NT-3 growth factors receptor2.7.10.10.460
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.447
2dteNAIGlucose 1-dehydrogenase related protein/0.445
3gcsBAXMitogen-activated protein kinase 14/0.445
3lfbZ87Mitogen-activated protein kinase 14/0.444