sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3e93 | 19B | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3e93 | 19B | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 3nnu | EDB | Mitogen-activated protein kinase 14 | / | 0.641 | |
| 3uvr | 06F | Mitogen-activated protein kinase 14 | / | 0.639 | |
| 1w82 | L10 | Mitogen-activated protein kinase 14 | / | 0.617 | |
| 3nnw | EDD | Mitogen-activated protein kinase 14 | / | 0.606 | |
| 3nnx | EDD | Mitogen-activated protein kinase 14 | / | 0.603 | |
| 3k3j | F4C | Mitogen-activated protein kinase 14 | / | 0.588 | |
| 3p79 | P79 | Mitogen-activated protein kinase 14 | / | 0.585 | |
| 3o8u | BMU | Mitogen-activated protein kinase 14 | / | 0.583 | |
| 3gcu | R48 | Mitogen-activated protein kinase 14 | / | 0.582 | |
| 3gi3 | B10 | Mitogen-activated protein kinase 14 | / | 0.572 | |
| 3hv4 | L51 | Mitogen-activated protein kinase 14 | / | 0.567 | |
| 3hv7 | 1AU | Mitogen-activated protein kinase 14 | / | 0.563 | |
| 1wbn | L09 | Mitogen-activated protein kinase 14 | / | 0.561 | |
| 1kv2 | B96 | Mitogen-activated protein kinase 14 | / | 0.557 | |
| 3d83 | GK6 | Mitogen-activated protein kinase 14 | / | 0.557 | |
| 3p7c | P7C | Mitogen-activated protein kinase 14 | / | 0.556 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.550 | |
| 3npc | B96 | Mitogen-activated protein kinase 9 | 2.7.11.24 | 0.549 | |
| 1wbs | LI2 | Mitogen-activated protein kinase 14 | / | 0.547 | |
| 2puu | G2G | Mitogen-activated protein kinase 14 | / | 0.547 | |
| 3kq7 | KQ7 | Mitogen-activated protein kinase 14 | / | 0.545 | |
| 5hid | B1E | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.545 | |
| 3p78 | P78 | Mitogen-activated protein kinase 14 | / | 0.540 | |
| 1wbt | WBT | Mitogen-activated protein kinase 14 | / | 0.538 | |
| 3p7a | P7A | Mitogen-activated protein kinase 14 | / | 0.535 | |
| 1kv1 | BMU | Mitogen-activated protein kinase 14 | / | 0.533 | |
| 2yis | YIS | Mitogen-activated protein kinase 14 | / | 0.531 | |
| 3hv6 | R39 | Mitogen-activated protein kinase 14 | / | 0.529 | |
| 3ugc | 046 | Tyrosine-protein kinase JAK2 | / | 0.529 | |
| 3lfb | Z87 | Mitogen-activated protein kinase 14 | / | 0.528 | |
| 2yiw | YIW | Mitogen-activated protein kinase 14 | / | 0.526 | |
| 4l8m | F46 | Mitogen-activated protein kinase 14 | / | 0.519 | |
| 3p7b | P7B | Mitogen-activated protein kinase 14 | / | 0.518 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.517 | |
| 3vhe | 42Q | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.516 | |
| 3gcv | SS6 | Mitogen-activated protein kinase 14 | / | 0.514 | |
| 1wbv | LI3 | Mitogen-activated protein kinase 14 | / | 0.513 | |
| 4fc0 | 0T2 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.512 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.503 | |
| 1n07 | FMN | Riboflavin kinase | 2.7.1.26 | 0.495 | |
| 2e2b | 406 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.493 | |
| 4u0i | 0LI | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.493 | |
| 4kfg | DOO | DNA gyrase subunit B | / | 0.491 | |
| 3wze | BAX | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.490 | |
| 3lfn | A27 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.488 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.488 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.485 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.485 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 3fgo | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.484 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.482 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.482 | |
| 2hiw | 7MP | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.481 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.481 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.480 | |
| 4g3p | UD1 | Bifunctional protein GlmU | / | 0.480 | |
| 3cd5 | 7HI | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.479 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.478 | |
| 2fyp | RDE | Endoplasmin | / | 0.477 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.477 | |
| 4f7j | 0SU | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.477 | |
| 2exl | GDM | Endoplasmin | / | 0.476 | |
| 3kkv | B99 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.476 | |
| 3qw2 | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.476 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.475 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.475 | |
| 3hji | FAD | Vivid PAS protein VVD | / | 0.475 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.475 | |
| 4bew | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.475 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.475 | |
| 2bf4 | NAP | NADPH--cytochrome P450 reductase | / | 0.474 | |
| 3s1c | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.474 | |
| 1oiu | N76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.473 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.473 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.473 | |
| 1e1l | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.472 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.472 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 4lj3 | C2E | Cyclic di-GMP phosphodiesterase YahA | 3.1.4 | 0.472 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 3e8c | G96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.471 | |
| 4b5b | BBE | Glucose-1-phosphate thymidylyltransferase | / | 0.471 | |
| 5ify | UMP | Glucose-1-phosphate thymidylyltransferase | / | 0.471 | |
| 4z35 | ON9 | Lysophosphatidic acid receptor 1 | / | 0.471 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.470 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 4ans | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.470 | |
| 4bae | RWX | DNA gyrase subunit B | / | 0.470 | |
| 2a4l | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 3gg0 | FMN | Uncharacterized protein | / | 0.469 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.468 | |
| 2ccu | 2D9 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 3qai | XNN | Ketohexokinase | / | 0.468 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 4g3s | UD1 | Bifunctional protein GlmU | / | 0.468 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.468 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.468 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.467 | |
| 3ddq | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 3ezr | EZR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 3qa2 | XNA | Ketohexokinase | / | 0.466 | |
| 4fxf | ATP | Pyruvate kinase PKM | 2.7.1.40 | 0.466 | |
| 4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.466 | |
| 4ww0 | ADP | ATP-dependent zinc metalloprotease FtsH | / | 0.466 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 3uwq | U5P | Orotidine 5'-phosphate decarboxylase | / | 0.465 | |
| 4fa6 | 0TA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 4izy | 1J2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.465 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.465 | |
| 1hk1 | T44 | Serum albumin | / | 0.464 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 3spt | UD1 | Bifunctional protein GlmU | / | 0.464 | |
| 4i23 | 1C9 | Epidermal growth factor receptor | 2.7.10.1 | 0.464 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.464 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.463 | |
| 3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 3eek | 53S | Uncharacterized protein | / | 0.463 | |
| 4bur | NAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.463 | |
| 4eh9 | 0OQ | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 4f4p | 0SB | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.463 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.463 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.463 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 3iod | A6D | Pantothenate synthetase | 6.3.2.1 | 0.462 | |
| 3r7y | Z04 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 4ysw | NAI | Xanthine dehydrogenase/oxidase | / | 0.462 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.461 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.461 | |
| 2cke | IQU | Death-associated protein kinase 2 | / | 0.461 | |
| 3cs9 | NIL | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.461 | |
| 3lfq | A28 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 3r1y | X76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 1pme | SB2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.460 | |
| 2itv | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.460 | |
| 3qwj | X6A | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 3zc6 | VFC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.460 | |
| 4ei7 | GDP | Plasmid replication protein RepX | / | 0.460 | |
| 4o4f | ATP | Kinase | / | 0.460 | |
| 4s34 | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.460 | |
| 4up3 | NDP | Thioredoxin reductase | / | 0.460 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.459 | |
| 2hch | N5A | Endoplasmin | / | 0.459 | |
| 2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.459 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.459 | |
| 3sls | 77D | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.459 | |
| 1g41 | ADP | ATP-dependent protease ATPase subunit HslU | / | 0.458 | |
| 1hk3 | T44 | Serum albumin | / | 0.458 | |
| 2b55 | D31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 3hjk | FAD | Vivid PAS protein VVD | / | 0.458 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.458 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.458 | |
| 2o1v | ADP | Endoplasmin | / | 0.457 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 3eej | 53R | Uncharacterized protein | / | 0.457 | |
| 4ic7 | ANP | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.457 | |
| 2eb3 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 2g1q | N9H | Kinesin-like protein KIF11 | / | 0.456 | |
| 2itx | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 3gfz | FMN | Uncharacterized protein | / | 0.456 | |
| 3igg | EFQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.456 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.456 | |
| 4hys | 1BJ | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.456 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 4nt0 | 3DU | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.456 | |
| 4xli | 1N1 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.456 | |
| 5dg3 | U21 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | / | 0.456 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 1i58 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.455 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.455 | |
| 2c3i | IYZ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.455 | |
| 3gfy | FMN | Uncharacterized protein | / | 0.455 | |
| 3is2 | FAD | Vivid PAS protein VVD | / | 0.455 | |
| 3lu6 | IMX | Serum albumin | / | 0.455 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.455 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 4hgt | 15G | Casein kinase I isoform delta | 2.7.11.1 | 0.455 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.455 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.454 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.454 | |
| 2r3f | SC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.454 | |
| 2z7l | S91 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.454 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.454 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4f7n | 0SV | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.454 | |
| 4g3q | UD1 | Bifunctional protein GlmU | / | 0.454 | |
| 5a65 | TPP | Thiamine-triphosphatase | 3.6.1.28 | 0.454 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.453 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 2fme | 3QC | Kinesin-like protein KIF11 | / | 0.453 | |
| 2itu | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 2yiq | YIQ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.453 | |
| 3ad6 | KSC | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.453 | |
| 3anm | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.453 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.453 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.453 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4rpg | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.453 | |
| 5ani | ES4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 2zyb | KSL | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 3a8t | ATP | Adenylate isopentenyltransferase | / | 0.452 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4bcn | T9N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 1wvy | STU | Death-associated protein kinase 1 | 2.7.11.1 | 0.451 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2wle | COA | Polysialic acid O-acetyltransferase | / | 0.451 | |
| 3cqw | CQW | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.451 | |
| 3dj4 | UD1 | Bifunctional protein GlmU | / | 0.451 | |
| 3lff | Z83 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3mj5 | GRM | Replicase polyprotein 1a | 3.4.22 | 0.451 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.451 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3umo | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.451 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4fu0 | ADP | D-alanine--D-alanine ligase | / | 0.451 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.451 | |
| 2q28 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.450 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.450 | |
| 3rkb | 12Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3v04 | V04 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.450 | |
| 4ccu | AWF | ALK tyrosine kinase receptor | 2.7.10.1 | 0.450 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.450 | |
| 4ndn | SAM | S-adenosylmethionine synthase isoform type-2 | 2.5.1.6 | 0.450 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.450 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 4ysw | FAD | Xanthine dehydrogenase/oxidase | / | 0.450 | |
| 4z69 | DIF | Serum albumin | / | 0.450 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.450 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.449 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.449 | |
| 2nom | DUT | Poly(A) polymerase, putative | / | 0.449 | |
| 3fnl | SHA | Lactoperoxidase | / | 0.449 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.449 | |
| 3w2o | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 4b1v | LAB | Actin, alpha skeletal muscle | / | 0.449 | |
| 4bco | T6Q | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4ccb | OFG | ALK tyrosine kinase receptor | 2.7.10.1 | 0.449 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4fkj | 11K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 1lhv | NOG | Sex hormone-binding globulin | / | 0.448 | |
| 2bm9 | SAM | Cephalosporin hydroxylase CmcI | / | 0.448 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2itw | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2xka | GSP | Cell division protein FtsZ | / | 0.448 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 3alm | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.448 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.448 | |
| 3lu7 | IPX | Serum albumin | / | 0.448 | |
| 3orm | AGS | Serine/threonine protein kinase | / | 0.448 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3sig | AR6 | Uncharacterized protein | / | 0.448 | |
| 3zlm | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.448 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4s32 | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 5c8y | ACP | Tubulin tyrosine ligase | / | 0.448 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.447 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.447 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 2x60 | GTP | Mannose-1-phosphate guanylyltransferase | / | 0.447 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.447 | |
| 4gvj | ADP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.447 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.447 | |
| 4r3a | RBF | Blue-light-activated histidine kinase 2 | 2.7.13.3 | 0.447 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.447 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.446 | |
| 2bxo | OPB | Serum albumin | / | 0.446 | |
| 2c69 | CT8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.446 | |
| 2v51 | LAB | Actin, alpha skeletal muscle | / | 0.446 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.446 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.446 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3mv5 | XFE | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.446 | |
| 4hz5 | 19Y | DNA topoisomerase 4 subunit B | / | 0.446 | |
| 4oa9 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.446 | |
| 4r7i | STI | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.446 | |
| 4tv3 | ML9 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.446 | |
| 1hk2 | T44 | Serum albumin | / | 0.445 | |
| 1ie4 | T44 | Transthyretin | / | 0.445 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
| 2xy9 | 3ES | Angiotensin-converting enzyme | 3.2.1 | 0.445 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3cy2 | MB9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3pju | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.445 | |
| 3q92 | XNB | Ketohexokinase | / | 0.445 | |
| 4eip | K2C | Putative FAD-monooxygenase | / | 0.445 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.445 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4hw7 | 64M | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.445 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.445 | |
| 1n9n | FMN | Putative blue light receptor | / | 0.444 | |
| 1sx4 | ADP | 60 kDa chaperonin | / | 0.444 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 2y3r | TIR | TamL | / | 0.444 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3pjt | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.444 | |
| 3t99 | ADP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.444 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.444 | |
| 4bcp | T3C | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4ekk | ANP | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.444 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.444 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 1m0w | ANP | Glutathione synthetase | 6.3.2.3 | 0.443 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2c5y | MTW | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 2xm9 | LWH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 2xp2 | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.443 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3fwr | ADP | Transcriptional repressor CcpN | / | 0.443 | |
| 3pp1 | IZG | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.443 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.443 | |
| 3s85 | LK0 | Gag-Pol polyprotein | / | 0.443 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.443 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4fv8 | E63 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4i1r | LZU | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 3.4.22 | 0.443 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.443 | |
| 4wuj | FMN | Glycoside hydrolase family 15, cellulose signaling associated protein envoy | / | 0.443 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.442 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2o1u | ANP | Endoplasmin | / | 0.442 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2xvw | 9NR | Serum albumin | / | 0.442 | |
| 2yfx | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.442 | |
| 3d72 | FAD | Vivid PAS protein VVD | / | 0.442 | |
| 3ffk | ATP | Actin, alpha skeletal muscle | / | 0.442 | |
| 3fws | ANP | Transcriptional repressor CcpN | / | 0.442 | |
| 3m6g | ATP | Actin, alpha skeletal muscle | / | 0.442 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.442 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.442 | |
| 4fkl | CK2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4fux | E75 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.442 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.442 | |
| 4mxy | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 4mxz | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 4wbb | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 2yy8 | MTA | tRNA (cytidine(56)-2'-O)-methyltransferase | / | 0.441 | |
| 3fls | FLS | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3qfc | NAP | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3ufp | H4W | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.441 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.441 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4xf7 | ACP | Carbohydrate/pyrimidine kinase, PfkB family | / | 0.441 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1j7k | ATP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.440 | |
| 1unh | IXM | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.440 | |
| 1w84 | L12 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 1wc6 | TAT | Adenylate cyclase | / | 0.440 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.440 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 2o12 | FMN | Chorismate synthase | / | 0.440 | |
| 2p55 | MRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.440 | |
| 3gvu | STI | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.440 | |
| 3ls8 | AJZ | Phosphatidylinositol 3-kinase catalytic subunit type 3 | 2.7.1.137 | 0.440 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.440 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.440 | |
| 4ful | 0VU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4fyo | 0VF | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.440 | |
| 4gdc | FAD | UDP-galactopyranose mutase | / | 0.440 | |
| 4imw | 1EV | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 4uux | APR | CinA-like protein | / | 0.440 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.440 |