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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3e01PZ2Gag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3e01PZ2Gag-Pol polyprotein2.7.7.491.000
3dolGWIPol protein/0.643
3c6tM14Gag-Pol polyprotein2.7.7.490.624
3t1a5MAGag-Pol polyprotein2.7.7.490.620
3c6uM22Gag-Pol polyprotein2.7.7.490.603
4mfb29TGag-Pol polyprotein2.7.7.490.598
4rw6494Gag-Pol polyprotein2.7.7.490.598
3dyaPZLGag-Pol polyprotein2.7.7.490.594
3ffi3OBGag-Pol polyprotein2.7.7.490.594
2ynhEURGag-Pol polyprotein2.7.7.490.587
3t195MAGag-Pol polyprotein2.7.7.490.583
4rw4494Gag-Pol polyprotein2.7.7.490.581
3drpR8EGag-Pol polyprotein2.7.7.490.576
1rtiHEFGag-Pol polyprotein2.7.7.490.575
2ynfWHUGag-Pol polyprotein2.7.7.490.572
1jlaTNKGag-Pol polyprotein2.7.7.490.571
3drrR8EGag-Pol polyprotein2.7.7.490.571
3dokGWJPol protein/0.566
3dmjGWEPol protein/0.565
3dlgGWEGag-Pol polyprotein2.7.7.490.563
2be2R22Gag-Pol polyprotein2.7.7.490.546
3tamM06Gag-Pol polyprotein2.7.7.490.544
1rt1MKCGag-Pol polyprotein2.7.7.490.541
3lakKR1Gag-Pol polyprotein2.7.7.490.539
1rt2TNKGag-Pol polyprotein2.7.7.490.533
3dleGFAGag-Pol polyprotein2.7.7.490.528
1c1bGCAGag-Pol polyprotein2.7.7.490.526
4i7fNVEGag-Pol polyprotein2.7.7.490.526
3i0rRT3Gag-Pol polyprotein2.7.7.490.515
3i0sRT7Gag-Pol polyprotein2.7.7.490.514
3lamKRPGag-Pol polyprotein2.7.7.490.513
1s1vTNKGag-Pol polyprotein2.7.7.490.505
1ep4S11Gag-Pol polyprotein2.7.7.490.501
1klmSPPGag-Pol polyprotein2.7.7.490.498
3lanKBTGag-Pol polyprotein2.7.7.490.497
1c1c612Gag-Pol polyprotein2.7.7.490.482
1fmlRTLRetinol dehydratase/0.480
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.479
3nbpJGZGag-Pol polyprotein2.7.7.490.479
2c3qGTXGlutathione S-transferase theta-12.5.1.180.476
3di6PDZGag-Pol polyprotein2.7.7.490.476
1x8lOXRRetinol dehydratase/0.472
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.471
4ez50RSCyclin-dependent kinase 62.7.11.220.467
1hquHBYGag-Pol polyprotein2.7.7.490.466
1fmjRTLRetinol dehydratase/0.465
2ar8FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.465
3m8qDJZGag-Pol polyprotein2.7.7.490.465
1tvrTB9Gag-Pol polyprotein2.7.7.490.464
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.462
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.461
2jn3JN3Fatty acid-binding protein, liver/0.460
3u8hBHPPhospholipase A2, membrane associated/0.460
2ardFDAFlavin-dependent tryptophan halogenase PrnA1.14.19.90.457
2vzmNRBCytochrome P450 monooxygenase PikC/0.457
5dp2NAPCurF/0.457
1hpzAAPGag-Pol polyprotein2.7.7.490.456
3zuxTCHTransporter/0.456
4nb6444Nuclear receptor ROR-gamma/0.456
3v9v21LPeroxisome proliferator-activated receptor gamma/0.455
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
1jipKTN6-deoxyerythronolide B hydroxylase/0.451
2apgFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.450
2ic3HBYGag-Pol polyprotein2.7.7.490.449
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1q5dEPBEpothilone C/D epoxidase1.140.448
1v35NAIEnoyl-ACP reductase/0.448
4j6dTESCytochrome P450 monooxygenase/0.447
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.446
2rkiTT1Gag-Pol polyprotein2.7.7.490.446
2wetFADTryptophan 5-halogenase/0.446
3nxuRITCytochrome P450 3A4/0.446
5cyqT27Gag-Pol polyprotein2.7.7.490.446
4apuA2KProgesterone receptor/0.445
1yc2NADNAD-dependent protein deacylase 2/0.444
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
1pkfEPDEpothilone C/D epoxidase1.140.442
2dvlFADAcyl-CoA dehydrogenase/0.442
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.442
3p3zP3ZPutative cytochrome P450/0.442
4cd2FOLDihydrofolate reductase1.5.1.30.442
4h6rFDAProline dehydrogenase/0.442
1n4hREANuclear receptor ROR-beta/0.441
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1r2jFADFkbI/0.440
2ebaFADPutative glutaryl-CoA dehydrogenase/0.440
4fhi0S4Vitamin D3 receptor A/0.440