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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.740
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.706
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.692
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.688
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.681
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.674
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.648
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.640
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.625
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.625
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.619
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.607
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.597
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.588
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.588
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.585
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.585
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.572
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.561
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.489
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.461
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3v94WYQPhosphodiesterase/0.455
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441